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Any abnormal immune-mediated reaction to a drug or other external stimul= us, such as rash, tongue-swelling, and difficulty breathing.
Donor / Recipient
UNACCEPTABLE if anaphylaxis (life-threatening) or widespread allergy (i.= e. rash all over the skin) to latex.
ACCEPTABLE if mild localised contact allergy to latex (e.g. a rash on th= e hands from wearing latex gloves).
UNACCEPTABLE if life-threatening or other severe allergy to any anaesthe= tic agent. However, other adverse effects (such as nausea, vomiting, fatigu= e) may be acceptable.
ACCEPTABLE at the discretion of the assessing physician. Donors with mul= tiple severe allergies, particularly with a history of anaphylaxis to more = than one allergen should not donate.
ACCEPTABLE if currently undergoing desensitisation therapy.
Inform transplant centre AND collection centre of any allergy, including h=
ayfever.
During donation donors are exposed to a number of potential allergens, i= ncluding G-CSF, anaesthetic agents and latex. There is a possibility of tra= nsfer of allergy to the recipient.
Tulpule S, Shaw BE, Makoni P, Little AM, Madrigal JA, Goldman JM. Severe= allergic reaction with anaphylaxis to G-CSF (lenograstim) in a healthy don= or. Bone Marrow Transplant 2009; 44(2): 129-30.
Hallstrand TS, Sprenger JD, Agosti JM, Longton GM, Witherspoon RP, Hende= rson WR, Jr. Long-term acquisition of allergen-specific IgE and asthma foll= owing allogeneic bone marrow transplantation from allergic donors. Blood 20= 04; 104(10): 3086-90.