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Inherited retinal degeneration with progressive loss of photoreceptor ce= lls
Donor
ACCEPTABLE
There is no evidence to support an adverse effect of stem cell mobilisat= ion in donors with RP. Indeed, G-CSF has been shown to increase photorecept= or survival and is even discussed as a novel therapeutic approach:
Oishi A, Otani A, Sasahara M, Kojima H, Nakamura H, Yodoi Y, Yoshimura N= . Granulocyte colony-stimulating factor protects retinal photoreceptor cell= s against light-induced damage. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):= 5629-35. doi: 10.1167/iovs.08-1711. Epub 2008 Aug 1. [1].
Any impact of bone marrow collection also seems highly unlikely.