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Panel
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titlebasicTypes.xsd
Code Block
languagexml
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firstline1059
titleVersion 2.2
linenumberstrue
<xs:sequence>
			<xs:element name="A" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="B" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="C" type="hlaLocusType" minOccurs="0"/>
            <xs:element name="DRB1" type="hlaLocusType" minOccurs="0"/>


  • Add HLA-E after HLA-C, HLA-E only has DNA fields


Code Block
languagexml
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firstline1097
titleVersion 2.2
linenumberstrue
<xs:sequence>
			<xs:element name="A" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="B" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="C" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="E" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB1" type="hlaLocusType" minOccurs="0"/>


XML Examples Example to add the HLA-E:

Code Block
languagexml
<HLA>
	<A>...</A>
	<B>...</B>	
	<E>
		<DNA>
			<FIELD1>01:01:01:01</FIELD1>
			<FIELD2>01:01:01:02</FIELD2>
		</DNA>
	</E>
</HLA>



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Panel
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titlebasicTypes.xsd
Code Block
languagexml
themeRDark
firstline1063
titleVersion 2.2
linenumberstrue
			<xs:element name="DRB1" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="DRB3" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB4" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB5" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQB1" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="DPA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DPB1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
		</xs:sequence>


  • Add fields MICA and MICB as part of HLA

     Because of the request to add MICA and MICB, we see issues with naming of the existing schema type for HLA, so some improvements are made.

  • Change the type of "hlaLocusType" to "hlaLocusSerDnaType" (XSD structure optimization, no effect to XML structure)
  • Additionally 3 new schema types are added:
    - simpleType "hlaGlsFieldType"
    - complexType "hlaLocusGlsOnlyType"
    - complexType "hlaLocusSerDnaType"


Code Block
languagexml
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titleVersion 2.3
linenumberstrue
			<xs:element name="DRB1" type="hlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="DRB3" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB4" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB5" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQB1" type="hlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="DPA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DPB1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="MICA" type="hlaLocusGlsOnlyType" minOccurs="0"/>
			<xs:element name="MICB" type="hlaLocusGlsOnlyType" minOccurs="0"/>
		</xs:sequence>
Code Block
languagexml
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titleVersion 2.3
linenumberstrue
	<xs:simpleType name="hlaGlsFieldType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA typing result provided as GL String</xs:documentation>
		</xs:annotation>
		<xs:restriction base="xs:string">
			<xs:maxLength value="255"/>
		</xs:restriction>
	</xs:simpleType>
	<xs:complexType name="hlaLocusBaseType">
Code Block
languagexml
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titleVersion 2.3
linenumberstrue
	<xs:complexType name="hlaLocusSerDnaType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising SER and DNA fields</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
				<xs:sequence>
					<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="0"/>
				</xs:sequence>
			</xs:restriction>
		</xs:complexContent>
	</xs:complexType>
Code Block
languagexml
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titleVersion 2.3
linenumberstrue
	<xs:complexType name="hlaLocusGlsOnlyType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising a GL String only</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
				<xs:sequence>
					<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="0"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="0"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="1"/>
				</xs:sequence>
			</xs:restriction>
		</xs:complexContent>
	</xs:complexType>


Additional improvement to XSD structures:

  • "hlaLocusType" is improved to "hlaLocusBaseType"
  •  Add GLS field with type "hlaGlsFieldType"


Code Block
languagexml
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titleVersion 2.2
linenumberstrue
   <xs:complexType name="hlaLocusType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising SER and DNA fields</xs:documentation>
		</xs:annotation>								   							  				   				 										 				 																									  
		<xs:sequence>
			<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
			<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>																			  
		</xs:sequence>
	</xs:complexType>
Code Block
languagexml
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titleVersion 2.3
linenumberstrue
    <xs:complexType name="hlaLocusBaseType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus base type comprising SER, DNA and GLS fields</xs:documentation>
		</xs:annotation>
		<xs:sequence>
			<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
			<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>
			<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="1"/>
		</xs:sequence>
	</xs:complexType>


XML example to use MICA:

Code Block
languagexml
<HLA>
	<A>...</A>
	<B>...</B>	
	<DPB1>...</DPB1>
	<MICA>
		<GLS>008:01:01/008:01:02/008:03/008:04+018:01/018:02</GLS>
	</MICA>
</HLA>

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