Disease of the vasculature of the brain. This includes:
Stroke, or cerebrovascular accident, whether haemorrhagic or embolic
Transient ischaemic attack
Intracerebral haemorrhage, including subarachnoid, subdural and extradural bleeds
UNACCEPTABLE, PERMANENT DEFERRAL
Both embolic stroke and intracerebral haemorrhage have been reported as adverse events in stem cell donors. In order to reduce this risk, it is prudent to defer any donor with a history of cerebrovascular disease or accident.
Halter J, Kodera Y, Ispizua AU, Greinix HT, Schmitz N, Favre G, et al. Severe events in donors after allogeneic hematopoietic stem cell donation. Haematologica 2009;94(1):94-101.