These guidelines are intended to provide a baseline set of Match-Connect administration practices for all Match-Connect participants. Due to the critical nature of business operations facilitated via Match-Connect, it is expected that these guidelines will be followed closely and consistently. This should ensure the ongoing success of message exchange between Match-Connect partners.

The implementation of the central part of the Match-Connect architecture (broker, central hub) is based on the following principles:

The Match-Connect system acts as a central broker of information exchange between registries participating in the Match-Connect ecosystem, also called the central hub from here on.  The central hub bears the responsibility to:

In performing these duties, the Match-Connect system will inspect the contents of messages to determine who to route messages to and to perform basic validation.  This content is not intended to be reviewed by administrators of the system except in cases where this is required to analyze message failures or data synchronization problems.  The central system will never modify original message contents but additional meta information "blocks" will be added to ensure the receiving registry is aware of:

The high-level message flow can be found in Chapter 5.

1.1 - Definitions / Abbreviations

TermDefinitionAliases / Abbreviations
Application Programming Interface

A way for two or more computer programs to communicate with each other. A type of software interface, offering a service to other pieces of software.

API

Cord Blood Bank

An organization representing an inventory of cord blood units

CBB

Client Uniform Resource Locator

Client URL (cURL, pronounced “curl”) is a command line tool that enables data exchange between a device and a server through a terminal.

cURL / CURL

Differential upload

A differential upload (DIFF) is a method of synchronizing the donor / cord listings of registries with the WMDA.  A differential upload is a file containing only records which contain updates, as opposed to a full (FULL) file which contains all donor or cord records, regardless of whether the individual records have updates.

DIFF

Donor Registry

A registry representing donors

DR

European Marrow Donor Information System

A peer-to-peer system used for facilitation of the search and procurement process amongst registries.  This includes the EMDIS Communication System (ECS) which defines a protocol for message exchange and the various implementations of ECS (Ester, PerlECS, etc).  At a conceptual level, the EMDIS network includes the individual software implementations of each EMDIS hub (typically a registry).

EMDIS

Hypertext Transfer Protocol

The Hypertext Transfer Protocol (HTTP) is the foundation of the World Wide Web, and is used to load webpages using hypertext links. HTTP is an application layer protocol designed to transfer information between networked devices and runs on top of other layers of the network protocol stack.

HTTP

Human Leukocyte Antigen

The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

HLA

Match-Connect

The APIs and central system of the WMDA used for facilitation of the search and procurement process amongst registries.  This includes the infrastructure for routing of information between participating registries and associated business logic as defined in the Match-Connect Semantics.  APIs contained within Match-Connect are:

  • Patient APIs
  • Search APIs
  • Connect APIs

The Match-Connect system is intended as a centralized alternative to (and evolution of) the EMDIS system.

Central Hub

MC

Patient Registry

A registry representing patients

PR

Representational State Transfer

Representational State Transfer (REST) is a software architectural style that was created to guide the design and development of the architecture for the World Wide Web. REST defines a set of constraints for how the architecture of a distributed, Internet-scale hypermedia system, such as the Web, should behave

REST

RESTful

Search & Match Service

The APIs and user interface (UI) of the WMDA used for searching the global inventory of available donors and cord blood units by transplant centers and registries.  APIs contained within the Search & Match Service are:

  • Patient APIs
  • Search APIs

These APIs are leveraged in tandem with the Connect APIs as part of the overall Match-Connect system.

Search & Match

SM / S&M

Swagger

Swagger is a suite of tools for API developers and a former specification upon which the OpenAPI Specification is based.


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