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WMDA has implemented a streamlined workflow for initiating searches.

We understand that this change can be met with hesitation by users who have familiarized themselves with the previous workflow, so allow us to provide clarity on the rationale behind this adjustment and guide you through the new workflow.

Why the change?

Resource and traffic optimization
By streamlining the initiation of mismatch searches, we can conserve valuable resources and reduce traffic on our matching engines
Prevention of information overload
Starting searches with many results can overwhelm users and hinder the effectiveness of their search experience. Our streamlined approach helps mitigate this issue by providing more targeted and relevant search results from the outset.
Integrity
Simplifying mismatch search initiation also serves as a measure to prevent misuse of our service. By setting reasonable constraints, we uphold the integrity of Search and Match and ensure fair access for all users.
Enhanced privacy and security
A streamlined workflow aligns with our commitment to safeguarding donor and patient privacy. By minimizing superfluous data transmission, we reduce the potential exposure of sensitive information, enhancing the robustness of our platform.

How to start a (next) mismatch search?

It is only allowed to start a (next) mismatch search via our Search and Match webpage if a previous (mis)match search within the same match class has finished and has <40.000 results
e.g. you can always start a 10/10, 8/8, or 6/6 search
However, you can only start a 9/10 search after finishing a 10/10 search that has <40.000 results, you can only start a 6/8 search after finishing an 8/8 and 7/8 with <40.000 results, you can only start a 4/6 search after finishing an 6/6 and 5/6 with <40.000 results
It is only allowed to start a next mismatch search via the search API if a previous mismatch search within the same match class has finished and has <40.000 results
e.g. you can always start a 10/10, 9/10, 8/8, 7/8, 6/6 or 5/6 search
However, you can only start an 8/10 search after finishing a 9/10 search that has <40.000 results, you can only start a 6/8 search after finishing a 7/8 with <40.000 results, you can only start a 4/6 search after a 5/6 with <40.000 results

See the illustration below for a visualization of allowed and non-allowed searches, based on the available typing for a patient

@startuml
actor patient
box "allowed searches" #lightblue
participant "Searches - possible"
end box
box "not allowed searches" #salmon
participant "Searches - not possible"
end box
patient -> "Searches - possible" : **possible searches**
... <color red>*it is only allowed to start the __next__ mismatch search if a previous search has <40.000 results and if a previous (mis)match search has finished in the same match class</color> ...
rnote over patient
**At least HLA typing at**
* A
* B
* C
* DRB1
* DQB1

* //Optional: DPB1, DPA1, DQA1, DRB3, DRB4, DRB5//
endrnote

/rnote over "Searches - possible"
**n/10 search**
**lociToBeConsidered**
__MUST BE: A, B, C, DRB1, DQB1 (Default)__
* overallMismatches: 0 10/10
* overallMismatches: 1 9/10
* overallMismatches: 2 8/10
* overallMismatches: 3 7/10 (<color red>*CBU only</color>)
* overallMismatches: 4 6/10 (<color red>*CBU only</color>)

**n/8 search**
**lociToBeConsidered**
__MUST BE A, B, C, DRB1__
* overallMismatches: 0 8/8
* overallMismatches: 1 7/8
* overallMismatches: 2 6/8
* overallMismatches: 3 5/8 (<color red>*CBU only</color>)
* overallMismatches: 4 4/8 (<color red>*CBU only</color>)

**n/6 search**
**lociToBeConsidered**
__MUST BE A, B, DRB1__
* overallMismatches: 0 6/6
* overallMismatches: 1 5/6
* overallMismatches: 2 4/6
* overallMismatches: 3 3/6 (<color red>*CBU only</color>)

**n/6 AB Low DRB High search**
(isCbuAbLowDrb1HighResolution = true)
**lociToBeConsidered**
__MUST BE A, B, DRB1__
* overallMismatches: 0 6/6
* overallMismatches: 1 5/6
* overallMismatches: 2 4/6 (<color red>*CBU only</color>)

endrnote

/rnote over "Searches - not possible"
**n/10 search**
**lociToBeConsidered**
__Any other combination of 5 loci than: A, B, C, DRB1, DQB1__
* overallMismatches: 5 5/10
* overallMismatches: 6 4/10
* overallMismatches: 7 3/10
* overallMismatches: 8 2/10

**n/8 search**
**lociToBeConsidered**
__Any other combination of 4 loci than: A, B, C, DRB1__
* overallMismatches: 5 3/8
* overallMismatches: 6 2/8
* overallMismatches: 7 1/8
* overallMismatches: 8 0/8

**n/6 search**
**lociToBeConsidered**
__Any other combination of 3 loci than: A, B, DRB1__
* overallMismatches: 4 2/6
* overallMismatches: 5 1/6
* overallMismatches: 6 0/6

**n/6 AB Low DRB High search**
(isCbuAbLowDrb1HighResolution = true)
**lociToBeConsidered**
__Any other combination of 3 loci than: A, B, DRB1__
* overallMismatches: 3 3/6
* overallMismatches: 4 2/6
* overallMismatches: 5 1/6
* overallMismatches: 6 0/6 

**n/4 search**
**lociToBeConsidered**
__Any combination of 2 loci__
* overallMismatches: 0 4/4
* overallMismatches: 1 3/4
* overallMismatches: 2 2/4
* overallMismatches: 3 1/4
* overallMismatches: 4 0/4

**n/2 search**
**lociToBeConsidered**
__Any single locus__
* overallMismatches: 0 2/2
* overallMismatches: 1 1/2
* overallMismatches: 2 0/2
endrnote

patient -> "Searches - possible" : **possible searches**
rnote over patient
**At least HLA typing at**
* A
* B
* C
* DRB1

* //Optional: DPB1, DPA1, DQA1, DRB3, DRB4, DRB5//
endrnote

/rnote over "Searches - possible"
**n/8 search**
**lociToBeConsidered**
__MUST BE A, B, C, DRB1 (Default)__
* overallMismatches: 0 8/8
* overallMismatches: 1 7/8
* overallMismatches: 2 6/8
* overallMismatches: 3 5/8 (<color red>*CBU only</color>)
* overallMismatches: 4 4/8 (<color red>*CBU only</color>)

**n/6 search**
**lociToBeConsidered**
__MUST BE A, B, DRB1__
* overallMismatches: 0 6/6
* overallMismatches: 1 5/6
* overallMismatches: 2 4/6
* overallMismatches: 3 3/6 (<color red>*CBU only</color>)

**n/6 AB Low DRB High search**
(isCbuAbLowDrb1HighResolution = true)
**lociToBeConsidered**
__MUST BE A, B, DRB1__
* overallMismatches: 0 6/6
* overallMismatches: 1 5/6
* overallMismatches: 2 4/6 (<color red>*CBU only</color>)
endrnote

patient -> "Searches - possible" : **possible searches**
rnote over patient
**At least HLA typing at**
* A
* B
* DRB1

* //Optional: DPB1, DPA1, DQA1, DRB3, DRB4, DRB5//
endrnote

/rnote over "Searches - possible"
**n/6 search**
**lociToBeConsidered**
__ MUST BE A, B, DRB1 (Default)__
* overallMismatches: 0 6/6
* overallMismatches: 1 5/6
* overallMismatches: 2 4/6
* overallMismatches: 3 3/6 (<color red>*CBU only</color>)

**n/6 AB Low DRB High search**
(isCbuAbLowDrb1HighResolution = true)
**lociToBeConsidered**
__MUST BE A, B, DRB1__
* overallMismatches: 3 3/6
* overallMismatches: 4 2/6
* overallMismatches: 5 1/6
* overallMismatches: 6 0/6 
endrnote
@enduml