Condition
Uveitis (iritis, iridocyclitis, chorioretinitis); scleritis; (episcleritis); (conjunctivitis)
Basic information
Inflammation affecting parts of one or both eyes
Causes:
Infectious: Toxoplasmosis, CMV, leptospirosis, tuberculosis
Isolated autoimmune or non-infectious: HLA-B27 associated, traumatic/sympathetic ophthalmopathy, drug-induced
Associated with systemic diseases: Behçet's disease, arthritis, connective tissue diseases
Individual at risk
Donor; Recipient (if infectious or presumed transmission of autoimmune diseases)
Guidance at RECRUITMENT
NOT ACCEPTABLE if acute or chronic inflammatory process, unless transient viral conjunctivitis.
NOT ACCEPTABLE if there is associated systemic disease
ACCEPTABLE for BM only if recurring inflammation or increased risk for recurrence (HLA-B27) or exacerbation (toxoplasmic chorioretinitis) (if registry policy allows registration for BM only)
Proposed guidance at CT / WORK-UP
NOT ACCEPTABLE if acute or chronic inflammatory process
NOT ACCEPTABLE if there is associated systemic disease
ACCEPTABLE for BM only if recurring inflammation or increased risk for recurrence (HLA-B27) or exacerbation (toxoplasmic chorioretinitis)
Justification for guidance
Uveitis has been reported as side effect of GCSF.
Infectious eye diseases can aggravate years after initial treatment, and the role of GCSF in response to infectious agents is not fully understood.
History of eye inflammation in association with systemic diseases usually requires deferral due to the underlying condition. If such an association cannot be excluded at medical examination, consider BM only or temporary deferral.
References
Parkkali T, Volin L, Sirén MK, Ruutu T. Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor. Bone Marrow Transplant. 1996 Mar;17(3):433-4. [1]
Tsuchiyama J, Imajo K, Sakaguchi N, Yoshino T, Suzaki N, Kondo E, Kawata N, Okada K, Maeda T, Tomiyama Y, Tsubota T Recurrent idiopathic iridocyclitis after autologous peripheral blood stem-cell transplantation followed by G-CSF administration for acute lymphoblastic leukemia. Ann Hematol. 2000 May;79(5):269-71. [2]
Faucher B, Garcia-Meric P, Franck J, Minodier P, Francois P, Gonnet S, L'ollivier C, Piarroux R. Long-term ocular outcome in congenital toxoplasmosis: a prospective cohort of treated children. J Infect. 2012 Jan;64(1):104-9. doi: 10.1016/j.jinf.2011.10.008. Epub 2011 Oct 24. [3]