DKMS (Germany, Poland, US, UK, India and Chile)
Read here information from DKMS how they can organise a health availability check without blood collection instead of conventional Confirmatory/Verification Typing.
- Update December 18: Poland will be in lockdown from 28th of December till 17th of January. According to new rules, persons travelling with organized transport should be in quarantine for 10 days after coming to Poland. Therefore, we are going to advise all our TCs to pick up the product at Polish-German border as we used to do in March and April or pick up from CC by courier travelling by his own car.
- Update November 18: DKMS Policy on Cryopreservation during COVID-19 Pandemic
- DKMS does not generally recommend cryopreservation if donor availability is stable and transport to the transplant unit is considered safe. Remarkably, despite the rising numbers of infections, donor availability in Germany has remained stable throughout the pandemic, and no additional public health measures are expected to impact donor availability in the upcoming weeks. For DKMS Poland, availability was fluctuating in the last weeks, and the development for the near future is more difficult to predict. For US and UK, availability of donors for WU is restrictive (unchanged); for Chile and India, the transport restrictions stand in the foreground.
- Nevertheless, w e will not refuse COVID-based cryopreservation requests for all DKMS entities , regardless where a TC or the DC is located (including domestic).
- Collection capacity: we experience no pandemic-related significant reduction in collection capacities for PBSC, DLI, and BM. However, due to the usual end-of-the-year surge of requests, and a strong increase in postponements, collection slots are becoming scarce for this year. For US: Marrow capacity continues to be limited. We urge all TCs to avoid postponements and blocking collection slots for b ackup donors whenever possible . In order to reserve the slots for bone marrow donations for patients who, due to their diagnosis, require bone marrow only, we reserve the right to ask for a switch to PBSC if this would be a possible alternative for the patient's diagnosis. For Germany: there is a higher chance in getting the requested dates by accepting a Thur/Fri PBSC collection or if possible Friday only; we appreciate if TC consider this offer.
- Unfortunately, the rising number of stem cell products that will never be infused has forced us to adapt our requirements for evaluation of any cryopreservation request.
The prerequisites below must be met, in-line with WMDA SEAR Rapid Alert 07-2020:
- BM cryopreservation will be accepted only if excess cell counts can be expected (e.g., for small children)
- Conditioning should be planned as soon as possible after the product arrives.; for products cryopreserved at the collection units, longer periods apply. Please provide the scheduled dates for start of conditioning and for infusion with the cryopreservation request.
- The transplant center must assess and confirm recipient’s final eligibility for immediate transplantation before scheduled start of the donation procedure, i.e. the 1st dose of GCSF or hospital admission for BM collection, not only after arrival of the product. This must include:
- Recent health status
- Patient’s verification typing results
- Patient’s consent
- Donor’s extended and verification typing results
- Insurance covering or other financial resources for transplant expenses
- Capacity in the TC
- The TC needs to commit itself to gather this information and update the donor center about any changes in order to have a cryopreservation request approved. If this information, especially updated health status, is not provided before start of mobilization, the collection unit, donor center, or the donor may decide not to continue.
- Any postponement of planned conditioning / infusion dates must be communicated in a timely manner and may result in also postponing the collection, as would be the case with non-cryopreserved products.
Australia Australian Bone Marrow Donor Registry (ION-7748)
Austrian Bone Marrow Registry (ION-2614)
- Registry operational information available on: https://share.wmda.info/x/GxJcAQ
- Update February 9, 2021:
- Search: No Covid-19 related restrictions.
- CT and Workup Requests: Requests will be accepted as usual. Cryopreservation may be offered on request.
- Transport, Import and Export: There should be no restrictions at the border; Austrian authorities classify the delivery of stem cell products as commercial transport. This waiver can be used.
Belgium Marrow Donor Programme Belgium - MDPB (ION-4201)
- Registry operational information available on: https://share.wmda.info/x/QRJcAQ
- Update March 1, 2021: See https://share.wmda.info/x/X0uOF for updated travel restrictions and transport guidelines.
- Update April 2, 2020: The MDPB applies the following policy in line with the guidelines for blood donors:
Deferral after COVID-19 infection = 28 days after symptoms resolution and end of the treatment
Deferral after contact with a COVID-19 patient = 28 days
Deferral after travel or contact with a person who traveled in a high-risk area = no defer
Suitability of the donor must be evaluated on COVID-19 symptoms: gastrointestinal & fever & respiratory symptoms in the last 28 days. And on exhaustive interrogation on possible contacts with COVID-19 patients, the last 28 days is mandatory
PCR or antibody testing of the donor is not needed.
Source freezing is an option for intercontinental or airplane transportation. Not for quarantine reason but for travel hurdles.
Post-donation donor information in case of complaints till 14 days after the donation is advised.
Bulgarian Bone Marrow Donor Registry (ION-7197)
- Registry operational information available on: https://share.wmda.info/x/aRJcAQ
- Update January 28, 2021: Regarding the pandemic situation, all people that enter Bulgaria must have a negative COVID PCR test. If a PCR certificate is required for the couriers that travel from Bulgaria to other countries, we can assist with this, as our Department performs COVID PCR test and can issue the relevant certificate.
Canada Canadian Blood Services Stem Cell Registry (ION-5103)
Canada Héma-Québec Registry (ION-6912)
- Registry operational information available on: https://share.wmda.info/x/eRJcAQ
- Update March 18, 2020: As of March 18th, international flights will be permitted to land only at the international airports in Montreal, Toronto, Calgary and Vancouver. Canadian Prime Minister Justin Trudeau has issued a statement in which he announced that Canada is barring entry to all travellers who are not Canadian citizens, permanent residents or Americans. There does not seem to be any restriction for Canadians leaving the country but no person exhibiting symptoms of COVID-19 will be allowed to board a plane to Canada and air operators will be required to complete a basic health assessment of every passenger based on guidelines from the Public Health Agency of Canada. All returning travellers will have to undergo a 14 day isolation period prior to resuming normal activities. These measures will be in place until further notice but the Prime Minister warns that they are subject to change as the situation progresses. Héma-Québec is working closely with Canadian Blood Services and courier services in order to find solutions to minimize the impact on international stem cell transportation and will follow-up with relevant up-dates on the situation.
China Marrow Donor Programme - CMDP (ION-2197)
- Registry operational information available on: https://share.wmda.info/x/mRJcAQ
- Update March 3, 2020:
Policy: In response to the novel coronavirus (currently named COVID-19), CMDP has established the policy of hematopoietic stem cell donation for the period of epidemic prevention & control according to Chinese government's request and the WMDA's guidance. In the current situation, the work of CMDP is suffering some limitations and could not be carried out normally as before. But for individual cases, especially for those in critical condition and have no alternative treatment, CMDP would assess relevant risks and feasibility, and make reasonable arrangements so as to ensure the safety of donors, patients and employees of CMDP.
- Postpone donation: According to the novel coronavirus – guidance of WMDA, it is recommended to postpone donation in case of donors coming from risk area, or contacting with a confirmed case, or with History of COVID-19 infection. The deferred period would follow the WMDA's guidance.
- Search & Match: CMDP accepts searching request from overseas registries as usual. The follow-up procedures might be affected by a lot of factors, 1) local situation of infection prevention and control where matched donors reside, 2) donors’ history of travel and close contact with COVID-19 infection, 3) the safety measures and capability of relevant PE center and collection center, and 4) the willingness of donors and their families in such situations.
- CT requests: Due to the spread of COVID-19 around the world, Hong Kong SAR government restricts entry of travelers from mainland China until 8th May. As a result, CT blood samples from CMDP donors could not be shipped to oversea destinations during this period. This situation might be adjusted according to the decision of Hong Kong SAR government.
- Transplant and collection plan: CMDP will make suggestions based on situation of collection center and donor’s local infection prevention & control condition, which will be finalized by both parties on the premise of flight confirmed.
CMDP would report to WMDA if any critical contingency occurs.
And we are grateful to the understanding of worldwide registries as to this special situation.
Let's work together to get through this hard time.
Croatia Croatian Bone Marrow Donor Registry (ION-5712)
- Registry operational information available on: https://share.wmda.info/x/uRJcAQ
- Update April 1, 2020:
- CBMDR Registry personnel - Working mainly from home. All international registries can contact us as usual, by emails and / or mobile phones: 00 385 91 49 20 585 Nika Kalogjera, MD, Director (also emergency number!) and 00 385 91 49 21 178 Josipa Canic, office manager
- Search requests - CBMDR registry is accepting search requests from international registries as usual.
- CT process - CBMDR registry will temporarily stop providing blood samples at the VT stage for HLA typing and IDM testing’s. Due to the current COVID -19 situation, from 1st April until further notice, CBMDR will no longer send blood samples abroad. When contacting donors, we will check donor’s availability and perform the health history screening questionnaire, which includes also screening for COVID-19 exposure or infection. If further HLA typing is necessary, it will be carried out at any moment prior and closest to the donation process.
- Work up requests - CBMDR accept work-up request as usual. Please send requests for CT blood samples together with work up requests, as blood samples will be taken in addition to the pre-collection samples. Our recommendation for all transplant centers is to ask for PBSC collections ( in accordance with EBMT guidelines) and to cryopreserve stem cells . Please note that all donors will be tested on COVID-19 before starting G-CSF stimulation and day before collection. They are all advised and educated to follow standard hygiene measures and to respect social isolation before donation. After the donation, all donors will be followed up for any possible symptoms of COVID-19.
Cyprus Cyprus Bone Marrow Donor Registry (ION-9751)
- Registry operational information available on: https://share.wmda.info/x/xxJcAQ
- Update May 25, 2020: I nformation regarding COVID-19 measures at Larnaka & Pafos Airports. Important Announcement: Within the framework of the measures announced by the Republic of Cyprus regarding the gradual easing of the restrictions in flights operated to and from Larnaka and Pafos Airport, the action plan foresees two phases for the opening of the airports and the restoration of Cyprus’ connectivity with other countries, as follows:
- PHASE A: 9 – 19 June 2020: During Phase A, whoever arrives from the countries included both categories, will have to furnish a clear Covid-19 test from a certified laboratory to be allowed onboard. The test should have a negative result and be conducted within 72 hours before departure. Cypriot citizens and permanent residents in Cyprus, also have the opportunity to take the test upon their arrival in Cyprus. In this case and until the test results are issued, they are to remain in self-isolation at home.
- PHASE B: 20 June 2020: During Phase B, which commences on 20 June, any passenger arriving from countries belonging in Category A, will not need to have a test in place.
The classification of the countries was made based on their current epidemiological data. To this extend, two categories were created including countries with which connectivity is restored.
- Category A: Greece, Malta, Bulgaria, Norway, Austria, Finland, Slovenia, Hungary, Israel, Denmark, Germany, Slovakia, Lithuania.
- Category B: Switzerland, Poland, Romania, Croatia, Estonia and the Czech Republic.
For passengers arriving from countries included in Category B, will continue to need a clear COVID19 test issued 72 hours before their departure in order to be allowed onboard. Cypriot nationals and legal residents from those countries will be able to take the test upon their arrival to the island. In such an occasion and until the test results are issued, they will remain in self-isolation at home. For all other countries which are not included in the two categories, at any given time, the Republic of Cyprus will allow flights carrying solely Cypriot citizens and people to whom special permission will be granted. In this occasion, they would have to furnish a clear Covid-19 test conducted 72 hours previously, before they are allowed to board an aircraft to Cyprus. Alternatively, the test can be conducted upon their arrival to Cyprus, however passengers will remain at a designated area for 1 day or until the test results are issued.
All passengers arriving from countries which are not included in the two categories, will be transported to their houses to undergo a 14 day self-isolation. The cost for the laboratory test as well as the quarantine/self-isolation/transportation cost will be paid by the passenger. In countries where it is verified that the Authorities cannot provide laboratory test services, and in order to facilitate those passengers interested to travel to Cyprus, this facility will be provided upon their arrival in Cyprus.
The Ministry of Health will continue to evaluate the epidemiological data of the countries, in order to validate the inclusion of the countries in the abovementioned categories. In the following days, additional countries will be announced.
As of Monday, May 25 at 6am, people who are currently in quarantine will be allowed to go home and spend the remaining days in self- isolation, based on the category of their country of origin.
Those repatriating between May 25 and June 8 will be tested upon arrival and remain for one day at a designated place or until the result is issued. They will then go home and self-isolate for seven days if arriving from countries included in the two categories and 14 days if arriving from other countries.
Czechia Czech National Marrow Donor Registry Plzeň (ION-5440)
Czechia Czech Stem Cell Registry (ION-4753)
- Registry operational information available on: https://share.wmda.info/x/3xJcAQ
- Update December 10, 2020:
- Czech Stem Cells Registry is fully operational.
- VT blood samples are sent again.
- Work-ups are processed. Donor assessment includes risk evaluation for transmission of infectious disease including covid-19 and testing during work-up. Cryopreservation of the product (preferably in TC) is requested until further notice.
- Contact: email@example.com Phone: +420 23605 5580 / -5585 /-5586 /-5587 EMERGENCY: +420 602 250 797
- Couriers are excluded from travel restrictions, however we recommend to ask for a permit issued by the CSCR registry.
Denmark Danish Stem Cell Donors East (ION-7484)
- Registry operational information available on: https://share.wmda.info/display/WMDAREG/Operational+Information+ION-7484#/
- Update March 26, 2020: The registry stays operational. We can be reached on telephone (+45) 3545 3970 during normal working hours or by E-mail DSDE.firstname.lastname@example.org.
- Donors follow the national laws and recommendations from the Danish Government and Danish Health Authority.
- The registry accepts cryopreservation of products.
- Danish borders are closed but transportation of hematopoietic stem cell products for Danish or international patients is accepted as one of the creditable exceptions. The registry makes individual arrangements for each transport. The registry informs the police on the border when a transportation has been arranged. Additionally, the registry will provide the courier with a documentation to show at the border including a 24/7 telephone number to the medical director of the registry.
Denmark Stem Cell Donors West (ION-2015)
- Registry operational information available on: https://share.wmda.info/x/6xJcAQ
Update November 12, 2020: waiver
Update January 21, 2021:
- The registry is operational and will be so even in the event of an increasing pandemic in Denmark. It varies if staff is working home or will be in the office. You will always be able to reach us by e-mail using: email@example.com the emergency number on Registry Operational Information on WMDA Share
- Donor is routinely asked about travel activity within last 6 months and if they have any flu-like symptoms
- Donors are advised to follow the safety measures from the Danish Government and health care authority.
- We will accept that products are cryopreserved.
- The Danish borders are closed, but persons with a creditable purpose are allowed to enter. Medicine and stem cells are considered a creditable purpose, but the courier needs to show a negative COVID-19 test (antigen or PCR test are accepted). The test must be taken max. 24 hours before boarding the airplane, and in case of transit, before boarding the first airplane. If the courier cannot show a valid COVID-19 test, the courier will be denied access to the airplane with destination for Denmark.
- Passengers on connected flights to Denmark transiting in one or more airports have two different options:
- They can take a test no more than 24 hours before boarding the first flight
- They can take a test while in transit
Even when a test is taken in the first country of departure, the Danish testing requirement only applies to the connecting flight to Denmark. In the transit airport, the airline must make sure that test was taken no more than 24 hours before the passenger boarded the first flight. However, this possibility applies only if the ticket has been booked as a combined flight ticket.
Finnish Stem Cell Registry - FSCR (ION-9738)
- Registry operational information available on: https://share.wmda.info/x/9RJcAQ
- Update May 20, 2020:
- Cryopreservation of grafts: The FSCR registry accepts higher cell count requests due to cryopreservation.
- PBSC: Requests for 6 - 10 x 10^6 CD34+ / kg BW of the recipient are accepted. However, if the result of the first day of apheresis is > 6 x 10^6 CD34+, continuing the collection on the second day will be determined by the collection center physician. For pediatric patients, even higher cell counts per kg patient BW may be acceptable.
- BM: we cannot accept any requests that would lead to collection of more than 20mL/kg donor weight (TNC content is usually 15 – 20 x 10^6 / mL).
- Update April 17, 2020:
- Search: FSCR accepts search requests from registries and domestic transplant centers as usual, without Covid-19 related restrictions.
- CT and Workup Requests: Requests will be accepted as usual. To clarify the donor’s risk of infection, questioning has been extended for both CT and workup. We seek to minimize contacts for our donors. Thus, we recommend changing over from CT with blood samples to the Health & Availability Check in the case of well-typed donors. If donors develop symptoms related to Covid-19 during the work-up period, they will be tested for SARS-CoV-2, but routine testing of donors or products is not performed. The transplant center will be notified immediately once ineligibility or deferral has been determined. BM harvests may be more difficult to arrange, and there may be last minute changes in graft source. We recommend opting for PBSC whenever possible
- Transport, Import and Export: Restrictions in air travel to and from Finland continue to increase and we are trying to obtain more information from the responsible government authorities. Currently couriers can enter the country. However, they may only pass or receive the graft to or from a registry representative, and then go directly to an airport hotel and remain in quarantine-like conditions until their return flight. All trips must be made by taxi; no use of public transport is permitted. In case a courier is experiencing problems at the Finnish border, please call this mobile number: +358-50-396-9450.
France France Greffe De Moelle - FGM (ION-1804)
- Registry operational information available on: https://share.wmda.info/x/AxNcAQ
- Update November 11, 2020:
- FGM Registry Personnel: FGM fully operates, coordinator’s email address and cell phone number should be used.
For any urgent situation outside of office hours, please use the Emergency contact email and/or telephone: firstname.lastname@example.org / +33-6-88 22 35 28.
Search requests: FGM registry is accepting search requests from international registries as usual.
CT-process: FGM continues to provide blood samples at the time of the upfront search for donor’s HLA confirmatory typing and IDMs testings. When contacting donors, donor centers check donor availability and perform the health history screening questionnaire, which include COVID-19 exposure assessement.
Work-up requests: FGM registry currently accepts work-up requests as usual. All donors are asked about travel history, upcoming travel and exposure to COVID-19 within the last 28 days. BM collections can be requested, but the feasibility of the collection procedure will be discussed on a case to case basis. Particular attention is paid to those work-up requests, when the donors belong to medical or paramedical personnel working in specific hospital covid-19 areas. Therefore FGM recommends, to have identified a back-up donor.
Stem cell donation recommendations: Recommendations of the national health competent authorities (without prejudice to any other measures concerning other infectious agents):
Donor qualification: The donor biological eligibility includes testing the donor for SARS-CoV-2 virus by gene amplification (RT-PCR) on a naso-pharyngeal swab before the start of GCSF stimulation or close to the day of donation. Donors are asked to follow safety hygiene measures and are followed-up after the donation in order to detect any symptoms of Covid-19. The results are transmitted upon reception to the transplant team.
For donors having experienced documented SARS-CoV-2 infection, a stem cell collection can be accepted 28 days after the resolution of symptoms.
Transport of HPC collected from French donors or international donors:
Transports from France to EU countries and vice versa are normal.
Transports from France to non EU countries : pickup at Paris Charles de Gaulle Airport hub can be requested.
Transports from non EU countries into France : delivery to Paris Charles de Gaulle Airport hub can be requested.
- Update May 27, 2020:
- Official statement, link (3rd stage of COVID-19 epidemic)
- FGM Registry Personnel: FGM staff will progressively be returning to FGM offices, current mail/cell phone numbers can still be used. For any urgent situation, please use the Emergency contact email and/or telephone: email@example.com / +33- 6-88 22 35 28.
- Search requests: FGM registry is accepting search requests from international registries as usual.
- CT-process: FGM is now able to provide again blood samples at the VT stage for HLA typing and IDM testings. When contacting donors, donor centers will still check donor availability and perform the health history screening questionnaire, which continue to include screening for COVID-19 exposure.
- Work-up requests: FGM registry will accept work-up requests as usual. All donors are asked about travel history, upcoming travel and exposure to COVID-19 within the last 28 days. BM collections can again be requested, but the feasibility of the collection procedure will be discussed on a case to case basis.
- Stem cell donation recommendations: Recommendations of the national health competent authorities (without prejudice to any other measures concerning other infectious agents):
Donor qualification: The donor biological eligibility is carried out by testing the donor for the presence of the SARS-CoV-2 virus by gene amplification (RT-PCR) on a naso-pharyngeal swab [or, if impossible, on a blood sample (whole blood, serum or plasma)]. The results are transmitted upon reception to the transplant team. All donors are tested for SARS-CoV-2 before the start of GCSF stimulation and close to the day of donation. Donors are asked to follow safety hygiene measures and are followed-up after the donation in order to detect any symptoms of Covid-19. For donors having experienced documented SARS-CoV-2 infection, a stem cell collection can be accepted 28 days after the resolution of symptoms.
- Transport of HPC collected from French donors or international donors:
Border documents required by the national authorities are still mandatory until all borders closure have been cancelled.
Cryopreservation of all unrelated products remains recommended at their reception by the transplant center facility, before the patient's conditioning starts. This recommendation is submitted to evolution according to the epidemic situation.
Germany ZKRD (ION-6939)
- Registry operational information available on: https://share.wmda.info/x/FxNcAQ and through a link to the ZKRD website, click here.
- December 15, 2020: Beginning December 16th, Germany will implement a complete lockdown for at least one month, which should not significantly impact the processes at our registry. Most colleagues continue to work from remote. For this reason, contact should primarily be via email, however staff can also be reached by phone. Our emergency numbers continue to be available 24/7, as usual.
- Search: The ZKRD continues to accept search requests from transplant centers and registries without any restrictions.
- CT: Requests will continue to be accepted as usual, although the provision of blood samples for confirmatory typing can be challenging in individual cases. We expect our partners to ensure that testing of samples provided will be carried out. Additionally, the Health and Availability Check (HAC) has been established as a regular service, and may be requested instead of a CT and prior to a combined CT-WU request for donors whose HLA has already been well-tested. Please see 3.5 of the German Standards for more information (https://www.zkrd.de/en/about_the_zkrd/german_standards.php). To clarify the donor’s risk of infection, health questionnaires have been amended to specifically include COVID-19 at both the CT and workup stages.
- Workup Requests: Routine medical examination of donors includes risk evaluation of COVID-19. The transplant center will be notified immediately if any ineligibility has been determined. Routine testing for SARS-CoV-2 will not be carried out on donors or products, as there is no evidence that COVID-19 is transmitted via bone marrow, blood or blood products.
- Cryopreservation: We have currently been supplying cryopreserved products as well as fresh cells. Taking into consideration EBMT and national recommendations, as far as the current individual patient and donor situations and transport conditions are concerned, the situation could necessitate cryopreservation or allow for transport of a fresh product. Therefore, we continue to recommend assessing the situation on a case-by-case basis, since the pandemic currently is very dynamic. Although we will generally be accepting more requests for cryopreservation due to the pandemic, all requests will continue to be reviewed by our registry and the donor center. Due to the number of products which have not been infused by the TCs, our requirements for approval of a request for cryopreservation have been amended. Generally, patient conditioning should be scheduled to begin shortly after arrival of the cryopreserved product. For all requests for cryopreservation, the TC is expected to confirm the patient status and scheduled timely infusion of the stem cells before the donor begins with G-CSF or is admitted for BM collection. All significant changes in patient status during the workup procedure need to be communicated immediately, as is the case for transplantation of fresh stem cell products.
- Transport, Import and Export: Overnight stays in hotels will not be permitted for private travel. Emergencies and business travel are exempt. Furthermore nighttime curfews has been put in place, but can be suspended for urgent reasons. To prevent couriers encountering any difficulties and to confirm the urgency of each stem cell transport, ZKRD has created a confirmation letter, which will be provided automatically to the respective registry / courier company. For *transiting couriers* please contact ZKRD Transport and Product Services (firstname.lastname@example.org) to provide a waiver for your courier.
Please note that currently the ZKRD *strongly* recommends using couriers from an experienced and audited courier company for pick-ups to or from international centers. Currently citizens of non-EU countries will only be permitted to enter the EU, and thus Germany, in cases of documented urgent need. All affected registries providing their own couriers should closely monitor travel restrictions and remain in contact with Transport Management. For products from German donor centers, please call the following number (ZKRD Transport Management) for assistance if couriers experience difficulties: +49 731 1507 201. For products involving DKMS donors: If a courier experiences problems you can call this mobile number: +49 174 192 59 36
Hong Kong Bone Marrow Donor Registry (ION-4070)
- Registry operational information available on: https://share.wmda.info/x/pxJcAQ
- Update January 2021:
Search Request: HKBMDR accepts donor and cord search requests from international registries as usual.
- Extended typing/CT Request: Requests will continue to be accepted as usual. Specific health and travel history enquiry will be done on donor. Donor with recent travel history or contact history with a confirmed case of COVID-19 within 28 days will be deferred from blood draw. For shipment of blood sample, a delay of 3-5 days with extra costs shall be expected as there are still limited international flights affecting postal and courier services.
Workup/Collection Request: HKBMDR accept work-up and collection request as usual. All donors will be asked on his travel history and exposure to COVID-19 within the last 28 days for risk evaluation. TC will be notified once an ineligibility or deferral is determined. Routine testing for COVID-19 will not be carried out on donors or products.
Export of Fresh Stem Cell Product: Starting from Dec 2020, any inbound traveler must undergo a 21-day of compulsory quarantine at designated quarantine hotel. Reservation of designated hotel must be confirmed before boarding. In order to ensure the safety of the recipients in this rapidly changing epidemic situation, TC are reminded to plan carefully on flight and courier arrangement for fresh product transport.
Cryopreservation: HKBMDR has recently been supplying cryopreserved PBSC products to overseas TC. All cryopreservation request will be reviewed by our registry. We recommend patient conditioning should be scheduled to begin shortly after arrival of cryopreserved product. Requesting registries are also required to locate international experienced and audited shipping company for the shipment of cryopreserved product.
HKBMDR Coordinators: HKBMDR personnel is working at the office as usual. All transplant centers and registries may continue to contact HKBMDR via email or fax: email@example.com or +852 2781 8498
Hungary Hungarian Stem Cell Donor Registry (ION-1695)
- Registry operational information available on: https://share.wmda.info/x/NRNcAQ
- Update September 1, 2020:
- Search: The Registry operate full capacity. We are available via email ( firstname.lastname@example.org ).
- VT & Workup:
- HBMDR accepts searching requests from registries as usual, our donors can provide blood samples for verification typing.
- To clarify the risk of infection on donors: If the donors have related symptoms, history of contact with COVID-19 cases or have been exposed to the risk area, the donation process on the donors will be deferred for four (4) weeks (according to the EBMT guideline).
- Organisation of HSC product export and import:
- Hungarian borders are closed for all non-citizens from Sept 1, 2020 with some exceptions including transport of the stem cell graft. Permit letter is required. HBMDR provides the partner organization with all information and documents regarding measures in Hungary, including necessary permit letters to allow traveling with product. We are working hard with competent authorities to find suitable solutions for each transport individually and we are in close contact with the relevant registries and transport company.
- In order to prevent any risk of harm to the recipients, our medical committee recommend allow the transplant centers to cryopreserve the products upon receipt and to start the conditioning regimen only after safe arrival of the product (according to the EBMT guideline).
- Registry operational information available on: https://share.wmda.info/x/d4JGE
- Update January 21, 2021 DKMS-BMST registry is accepting search requests from international registries as usual.
- CT-process: DKMS-BMST recommend a Health & Availability Check (HAC) instead of requesting a CT. A HAC request includes a donor health history questionnaire as well as an information session with the donor. Please be aware that a CT testing has to be performed before transplantation. Therefore, for donors without regular CT, a CT + Workup request (CT/WU-Combo) has to be requested, where CT samples are then taken in addition to the pre-collection samples on the day of donor’s physical examination.
- Work-up requests: DKMS-BMST registry currently accepts work-up requests as usual. Routine medical examination of donors is carried out including risk evaluation of COVID-19 exposure. The transplant center will be notified immediately if any ineligibility has been determined
- Transport of HPC collected- DKMS-BMST support in courier or cargo transports of HPC collected depending upon the flight availability. Flights are available for many destinations now but days of operations may be limited. However, we ask you to be flexible regarding the date of collection and the delivery date of the stem cells in your country. DKMS-BMST is prepared to support you in importing stem cells to India. RT-PCR negative test report is required to avoid institutional Quarantine. RT-PCR testing is available at all International airports for those without this report( or reports older than 72 hrs) .
Israel Ezer Mizion Registry Israel Bone Marrow Donor Registry (ION-4987)
Israel Hadassah Registry (ION-5239)
- Update December 24, 2020: Hadassah Bone Marrow Registry is able to provide a full service PBSC or BM. Although there is a partial lock down in Israel, we are fully active. All relevant departments including the laboratories work with us fully and provide immediate services. Hadassah BMR will be happy to assist locating donors and sending product if it will requested by TC. Hadassah BMR is working with an international shipping company ICL, which provides shipping services to the whole world, so far we are happy we have not
Italy Italian Bone Marrow Donor Registry (ION-1055)
- Registry operational information available on: https://share.wmda.info/x/qxNcAQ
- Update June 15, 2020: IBMDR operational activity
- extended/verification typing: our donors are fully committed to provide fresh blood samples for extended or verification typings. Most donor centers established COVID-free areas, so there is no increased risk for donors. Some donor centers contact the donor to check the elegibility by phone, by videocall etc...and only if the donor is considered fit, he/she is allowed to go to the donor center for the blood draw. We are experiencing still some but short delay in the delivery of the samples, but no incident reports were received due to the ineligibility of the received samples.
- HPC/lymphocite donation: according to the registered data of 2020 compared to 2019 (same period), we can document that the activity is currently as previous the pandemic. All the donors are tested for SARS-COV-2 by gene amplification (RT-PCR) before the administration of G-CSF or before the beginning of patient's conditioning regimen whichever occurred first. During the pandemic, no donors were found positive at time of testing before the donation procedure started.
- T ransport of HPC/lymphocites: since last 3rd of June, the National authorities opened the boarders of Italy and free circulation is allowed among the Italian Regions. This means that couriers could enter, move and exit from the countries without any restrictions or need to be quarantined. Furthermore since the 15th of June most national airports are opening (main HUBs of Rome Fiumicino and Milan Malpensa are restoring their operation), so new flights may be very shortly available. Of course if your couriers need any help, feel free to contact us, we will be pleased to help.
- Cryopreservation of the HPC : our competent authorities do not more strictly require to begin the patient conditioning regimen only after the receipt of the product. However they suggest to the transplant centers to evaluate the benefit/risk case by case. In case of cryopreservation the donor center will be informed.
- Questions? We are fully operative from 08:00 a.m. to 04:30 p.m. CEST and reachable at the following numbers: +39 01 056 344 34-35, in case of emergency, outside the bussiness hours, +39-320-8508989 or you could contact us by e-mail: email@example.com .
Japan Marrow Donor Program - JMDP (ION-4364)
- To transplant centres abroad: J MDP will do the best to coordinate our donors for your recipients according to your request, although some difficulties exist over Covid -9 pandemic. For the transportation of HSC from Japan to your country, we announce the followings;
- In case that fresh BM or PB is requested, it will be transferred at the appropriate airport from Japanese courier to the courier from your country.
- In case that a TC plans to cryopreserve the JMDP donor PBSC and asks Japanese harvest center to cryopreserve it, AC will cryopreserve it.
- In case that a TC plans to cryopreserve the JMDP donor BM and asks Japanese collection center to cryopreserve it, it may be difficult depending on CC.
- When cryopreserved product is required, please prepare a dry shipper by yourself.
We will continue to update as the COVID-19 situation changes.
Korea Marrow Donor Program -KMDP (WO-1058)
- Registry operational information available on: https://share.wmda.info/x/iwCZDw
- Update June 19, 2020: There are around 0~00 new confirmed cases everyday but now reducing numbers in Korea. KMDP is working as usual but we are still continuing social distancing.
- Search: KMDP accepts search requests from registries as usual, without any restrictions.
- CT and Workup Requests: Requests will be accepted as usual. To clarify the donor’s risk of infection, KMDP surveys all donors for both CT and workup stages. If donors have relevant symptoms, a history of contact with COVID-19 cases, the donors will be deferred for 4 weeks. The transplant center will be notified immediately once ineligibility or deferral has been determined. It depends on the collection center regarding the test for COVID-19 of the donor, but if TC requests a test we are able to test it.
- Transport, Import and Export: Any foreign country citizen entering Korea has to stay in quarantine for 14 days. Our strong recommendation is planned cryopreservation of adult donor products so that arrival of the product can be confirmed prior to the start of patient conditioning and prepare a dry shipper by requesting registry.
Netherlands Matchis (ION-8139)
Norway Norwegian Bone Marrow Donor Registry (ION-7214)
Poland Poltransplant (ION-5391)
- Registry operational information available on: https://share.wmda.info/x/DxRcAQ
- Update December 18, 2020: Poland will be in lockdown from 28th of December till 17th of January. According to new rules, persons travelling with organized transport should be in quarantine for 10 days after coming to Poland. Therefore, all TCs are advised to pick up the product at Polish-German border as in March and April or pick up from CC by courier travelling by own car.
- Update March 14, 2020: Yesterday the Polish government decided to close all air connections to Poland and all borders, since 15 of March all regular flights are cancelled. The only way to send transplant material abroad is via Germany and airport in Berlin. We are working hard on organization of transport for collections scheduled for week 16-22.03, addressing each case individually to ensure there is minimal impact to patients. Our DCs and CCs can transport the material to the border and hand on the cells to the courier from TC with the help of Polish border guards. It is not allowed to any foreign country citizen to enter Poland. Polish courier returning from abroad will have to stay in quarantine for 14 days. There is also a possibility of organizing special air transport via Okecie Airport in Warsaw. Our strong recommendation is planned cryopreservation of adult donor products so that arrival of the product can be confirmed prior to the start of patient conditioning. I trust that together we can face this difficult situation.
Portugal Cedace (ION-7358)
Romanian National Registry of Hematopoietic Stem Cells Voluntary Donors (ION 1372)
- Registry operational information available on: https://share.wmda.info/x/GxRcAQ
- Update June 16, 2020: Beginning with June 15th 2020, the authorities decided some relaxation measures within the state of alert applicable to the general population of Romania, taking into consideration the constant level under 2% of the confirmation index (the number of positive tests divided by the total number of tests performed). The flights to and from 17 countries can land on Romanian airports (Austria, Bulgaria, Czech Republic, Cyprus, Croatia, Switzerland, Germany, Greece, Iceland, Latvia, Liechtenstein, Lithuania, Malta, Norway, Slovakia, Slovenia and Hungary).
- RNDVCSH - Romanian Registry is committed to continue and provide all the services, with some restrictions during the state of alert that is prolonging till 30 of June or even 15 of July (only emergency services can be provided and BM collections are recommended to be postponed).
- RNDVCSH - Romanian Registry’s staff is back to the office and we are fully operational. All the communication channels are available and we can be contacted via EMDIS, fax or e-mail.
The following updates are provided:
- EXTENDED TYPING AND CONFIRMATORY (CT/VT) REQUESTS: We are taking the requests for extended typing in all those cases where the laboratory still has blood samples storage. If there are not blood sample, we are conducting a willingness and health assessment of the donors, and if the blood drawn is not possible we cancel the extended typing request.
Regarding CT VT/requests is our priority. We call donor for willingness and health, and if the donor is willing to travel for blood sample collection we can perform the requested service, if not we will postpone and the donor is reserved for 3 months.
- DONOR AVAILABILITY: Some restrictive traveling measures are in place and affect our donors' availability. The travel of donors from more than 30 km faraway of donor center, is allowed with a statement on her / his own responsibility.
- HEALTH SCREENING: To clarify the risk of infection on donors, we implemented a designated questionnaire in order to survey the donors for COVID-19 symptoms. Donors with active confirmed COVID-19 are not eligible for HSC donation. If the donors have related symptoms, history of contact with COVID-19 cases or have been exposed to SARS-CoV-2 (red areas of risk), the donation process of this donors will be deferred for four (4) weeks. The transplant centre will be notified immediately once an ineligibility or deferral is determined.
We perform testing for COVID-19 (done by real-time PCR) at the work-up and if the donor pas the clearence, on the day of donation (the recommendation for eligible persons for real-time PCR test can be access here http://www.cnscbt.ro/).
- CRYOPRESERVATION OF PBSC PRODUCTS: In order to prevent any risk of harm to the recipients, scientific board of RNDVCSH strongly recommend that all products be cryopreserved for every PBSC collection until further notice. They recommend an alternative donor as back-up in situations where there is an increased risk that a donor would become unavailable at the time of planned transplantation due to community-acquired COVID-19, travel restrictions or logistical difficulties at a transplant centre/collection center.
The transplant centers will cryopreserve the products upon receipt and will start the conditioning regimen only after safe arrival of the product. RNDVCSH also surveys the national donors, during 14 days after the collections to determine if the donors are at risk of COVID-19 infection and will notify the transplant centre as needed.
- BONE MARROW COLLECTION: In Romania, following the recent national measures for limitation of COVID-19 pandemic, restricted the access to the operating rooms and intensive care services. Till further notice, the bone marrow collection cannot be performed in Collection Centers.
- TRANSPORTATION: During the state of alert, flights to and from the following countries can land on Romanian airports: Austria, Bulgaria, Czech Republic, Cyprus, Croatia, Switzerland, Germany, Greece, Iceland, Latvia, Liechtenstein, Lithuania, Malta, Norway, Slovakia, Slovenia and Hungary. The list of the countries is updated weekly and new countries will be added. For all the European Union countries the road transportation is possible, and RNDVCSH will issue the import/export authorisation. We will also issue a certificate/letter for facilitating cross-border shipments of HSC as essential goods and services within the EU countries, and will inform national authorities regarding each transport.
- CONTACT INFORMATION: Aurora Dragomiristeanu firstname.lastname@example.org; +40722.751.147
We express our gratitude to transplantation community and worldwide bone marrow registries. With this challenge, we hope we could stay active to overcome this exceptional period.
Keep safe and stay well.
Russia Karelian Registry of Hematopoietic Stem Cells (ION-8256)
- Registry operational information available on: https://share.wmda.info/x/MRRcAQ
- Update June 15, 2020: Due to the pandemic of COVID-19, Russia has stopped all travel abroad (since March 27th) and adopted some restrictions for travel of civil individuals (since March 30th). However under certain circumstances people may leave their homes, in particular, to visit a medical office. Since the risk of donor infection with COVID-19 is quite high, some operations of the Karelian Registry cannot be performed in full scale. However, this greatly varies from one particular case to another, and we hope the restrictions will not hold for too long.
Singapore Bone Marrow Donor Programme (ION-3785)
- Registry operational information available on: https://share.wmda.info/x/TxRcAQ
- August 3, 2020: Singapore Ministry of Health has issued an advisory on HSCT during this COVID-19 period. In line with the advisory, BMDP has implemented the following guideline to assess our donors for medical suitability for donation. All donors are now required to be tested for COVID-19 before the donation. Please note that additional fees for this COVID-19 test will apply.
Ensure donors are free of respiratory symptoms for at least 14 days before planned donation.
Donors should not travel outside of Singapore for at least 14 days before planned donation.
Both PBSC and BM donors: Nasal swab COVID-19 test within 48 hours before planned donation.
If donor is tested positive for COVID-19, defer donation for 3 months from recovery/resolution of symptoms.
Donors with history of COVID-19 Infection
Defer collection for 3 months from recovery/resolution of symptoms.
Donors had contact with a confirmed COVID-19 case in the last 14 days
Defer collection for 28 days after donor’s last contact with person with confirmed COVID-19 infection
Donors with household members who have had contact with confirmed COVID-19 case in the last 14 days
Defer collection for 28 days after donor’s household members last contact with person with confirmed COVID-19 infection
Donors who are under quarantine order (QO), Stay-Home Notice (SHN), Leave-Of-Absence (LOA) or equivalent
Defer collection for 28 days after the last day of QO/SHN/LOA
South Africa South African Bone Marrow Registry (ION-8118)
- Registry operational information available on: https://share.wmda.info/x/bRRcAQ
- Update October 28, 2020: South Africa has developed a risk categorisation model for different international travellers. This model classifies international travellers according to a scale of high, medium and low risk. High risk travellers are those who come from countries with higher numbers of COVID-19 infections and reported deaths compared to South Africa. Medium risk travellers are from countries with relatively equal number of infections and death toll to South Africa and low risk travellers originate from countries with lesser number of infections of COVID-19 and death toll than South Africa. Travellers from medium and low risk countries can enter South Africa for both business and leisure on condition a negative coronavirus test result, less than 72 hours old, is available. If they do not have the test result, they will remain in mandatory quarantine at their own cost. Everyone arriving will be screened, and those who show any symptoms of COVID-19 will also be required to stay in quarantine until they test negative for the virus again. Travellers will be asked to install the South African Government’s contact alert app.
Business travellers from high risk countries with scarce and critical skills including diplomats, repatriated persons, investors and people participating in professional sporting and, events will have to apply for exemption to enter South Africa an email can be sent to Covid19BusinessTravel@dha.gov.za supported by:
- A copy of passport and/or temporary residence visa;
- Proof of business activities to be undertaken in the Republic;
- Proof of travel itinerary; and
- Proof of address or accommodation in the Republic.
Leisure travellers from high risk countries will not be permitted entry.To view the list of high risk countries please go to IATA’s travel centre website and click on South Africa https://www.iatatravelcentre.com/world.php this list will be updated every two weeks. For more frequently asked questions about the re-opening of South Africa’s borders for international travellers please follow this link http://www.dirco.gov.za/docs/2020/corona_virus0930.htm
Spain Registro de Donantes de Médula Ósea (REDMO) (ION-7813)
- Registry operational information available on: https://share.wmda.info/x/fRRcAQ
Update per November 23, 2020: We would like to update you with some new information about traveling to Spain. From November 23rd, 2020 and on it will be mandatory for all travelers to submit evidence of a negative SARS-Cov-2 PCR performed 72hrs prior to arrival. We worked with our Foreign Health Authorities to make an exception for couriers involved in the import/export of Hematopoietic Stem Cell products. In order to comply with the requirements, all couriers will need to fill in an online health check at this webpage: https://www.spth.gob.es/create In this questionnaire you will find a question asking whether you completed the PCR test. Even if you did not do it, you must answer: YES. This way, the system will generate the proper QR code for entering Spain. We are also in the process of getting an official Waiver from our Foreign Health Authorities that authorizes the free transit of couriers without the required screening test. Once we have this document, we will immediately distribute it. Nevertheless, if you experience any troubles during your trip, please urgently contact your REDMO-coordinator or our 24/7 emergency number: +34 689 306 356. Finally, we strongly recommend cryopreservation of all products entering and leaving Spain until the situation improves.
Update July 12, 2020:
As of today our transplant centres are being encouraged to schedule fresh infusions again. This means that in those cases where transport is reliable, they won´t be planning a cryopreservation upon arrival of the product anymore. For those cases in which cryopreservation of the product might still be needed, we would inform you about the procedure and our transplant centres have been asked to schedule the beginning of the conditioning regimen during the first 72hrs after reception of the product. We hope this new strategy is more consequent with the current state of the pandemic and we really hope the situation stays stable and favorable for our patients and donors.
Verification Typing: from 15.06.2020 it will be possible to request VT blood samples from all Spanish Donors. We will continue to perform the HAC including COVID-19 risk factors.
Transport: most Courier-Companies can make door to door transport of products, so that there is actually very little need of hand-over at the airports.
COVID-19 screening: our National Health Authorities keep on strongly recommending COVID-19 PCR screening of all stem cell donors, so that we will continue to perform the test in all our donors.
Sweden Tobias Registry Sweden Bone Marrow Donor Registry (ION-5285)
- Registry operational information available on: https://share.wmda.info/display/WMDAREG/Operational+Information+ION-5285#/
- Update March 27, 2020: The registry stays operational for all activities. Staff can work from home or will be at the office. You will always be able to reach us by e-mail using: email@example.com
- Donors is routinely asked if they have any flu-like symptoms.
- Donors are advised to follow the safety measures from the Swedish Government and health care authority. There are no travel restrictions within Sweden.
- We accept that products are cryopreserved.
- In response to the European Council’s and the European Commission’s call for travel restrictions, the Government decided on 17 March to temporarily stop non-essential travel to Sweden so as to mitigate the effects of the outbreak of the COVID-19 virus and reduce the spread of the disease but persons with a creditable purpose are allowed to enter. Medicine is considered a creditable purpose. The registry will provide documentation for the courier to show at the border that will allow them to travel to the Transplant Center or Collection Center. The documentation will be handled to the TC and the courier and it include a 24/7 phone number for the border police to confirm the purpose of the courier, if needed.
Switzerland Blutspende SRK Schweiz (Swiss Blood Stem Cells) (ION-9341)
- Registry operational information available on: https://share.wmda.info/x/mxRcAQ
- Update January 29, 2021:
- The Swiss blood stem cell transplant activity is working again under remote access conditions but otherwise under nearly normal conditions, on the patient side as well as on the donor side. However, we are also impacted by the restrictive measures that affect both courier travels and donor selection policies.
- In order to prevent any risk of harm to the recipients, our medical committee maintains its recommendation to accept all requests for cryopreservation by national and international transplant centers. This will allow the transplant centers to cryopreserve the products upon receipt and to start the conditioning regimen only after safe arrival of the product. Currently most Swiss transplant centers will request cryopreservation of the product, depending on the current local situation (spread of the virus in the corresponding country, donor situation, etc.). We will inform you accordingly.
- Concerning Swiss donors, we have defined specific donor selection policies, including testing, in order to minimize the risks for the donors themselves and for the recipients as far as possible. We will perform a Health & Availability Check (HAC) in the cases, where we are not able to perform a blood draw, however our priority process remains to perform a regular CT/VT including the collection of blood samples.
- Border control: Switzerland has open borders but travelers entering Switzerland from certain regions will have to go into quarantine for ten days. The FOPH (Ministry of Health) has a list of the countries concerned, which it updates regularly (https://www.bag.admin.ch/bag/en/home/krankheiten/ausbrueche-epidemien-pandemien/aktuelle-ausbrueche-epidemien/novel-cov/empfehlungen-fuer-reisende/quarantaene-einreisende.html#1918240392 ). Travelers affected will be notified during the flight, on board coaches and at border crossings. They will have to register with the cantonal authorities on arrival. Airlines and travel companies will also be instructed not to transport sick passengers. The Swiss Registry holds an additional authorization for the import and export of blood stem cells (06.07.2020 authorization Corona BAG) especially for the COVID-19 situation (Import/Export of DLIs) and we will provide this authorization for the cases where the Swiss registry is involved (national patients/donors and international donors/patients) in order to prevent courier staff from having to go into quarantine.
- NEW COVID-19 test requirements for couriers starting 08.02.2021: Switzerland is changing their requirements for quarantine and testing of travelers entering Switzerland starting 08.02.2021. Please note that couriers entering Switzerland to pickup or deliver blood stem cells are exempted from these requirements and do not need to quarantine or require a negative test when entering Switzerland. Couriers are still obliged to register with the Swiss FOPH and must provide their contact information before entry into Switzerland: https://swissplf.admin.ch.
- We offer assistance for couriers departing Switzerland and requiring a COVID-19 test in order to enter another country. Please notify our coordination team (firstname.lastname@example.org) in advance and we will help setting up a test. Test stations are available close to the Swiss collection centers and offer antigen tests with a turnaround of 30min. PCR testing requires considerably more time and therefore must be assessed individually in case it is absolutely necessary for the transport.
- Masks are compulsory on all public transport. It is also mandatory to wear a mask in all publicly accessible establishments and (indoor premises). This includes shops, banks and restaurants.
- We are grateful for your collaboration in helping us to maintain our blood stem cell transplant activity. We remain at your disposal for any kind of inquiries concerning this topic email@example.com / emergency calls: +41 31 380 81 01.
Taiwan Buddhist Tzu Chi Stem Cells Center - BTCSCC (ION-3458)
- Registry operational information available on: https://share.wmda.info/x/qxRcAQ
- Information in Chinese (find below the English Translation)
- Update June 23, 2020:
During the period of the serious COVID-19 outbreak, BTCSCC maintains its stem cell donations as the usual process but follows the policies declared by the Ministry of Health and Welfare, Taiwan .
To prevent the risk of non-related donors and recipients from getting an infection by COVID-19 while the Central Epidemic Command Center is still serving (before the risk of the infection is dismissed), the measures taken by BTCSCC are as follows:
- To clarify the risk of infection on donors, BTCSCC will survey the donors at CT and Work Up sages. If the donors have related symptoms, history of contact with COVID-19 cases or have been exposed to the risk area, the donation process on the donors will be deferred for 2 to 3 weeks. The TC will be notified once an ineligibility or deferral is determined.
At the donors’ work up stage, travel history of the donors will be revealed by the national health insurance system. The work up will be postponed once a related medical history, symptoms or any adverse sign on the donors’ chest imaging are observed. And the TC will be notified as soon as possible.
- BTCSCC will survey the donors 14 days before the collections to determine if they are at the risk of a COVID-19 infection.
BTCSCC staff will call and perform a health survey on the donation candidate every two weeks to see if there is any abnormal symptom.
BTCSCC will also survey the donors 14 days after the collections to determine if the donors are at the risk of COVID-19 infection and notify the TC as the supportive information for clinical purposes.
The TC should arrange a pick up date based on Dh (Day harvest) instead of Day0 with BTCSCC in the future. Dh may change and the product may not be able to arrive at the TC on the scheduled date due to flight changes or border closures. Please start the conditioning therapy or myeloablative conditioning therapy of the recipient after the arrivals of the products. And the product should be cryopreserved prior to the completion of the therapy. This strategy is to ensure the safety of the recipients in this rapidly changing epidemic situation.
All the registries or the TCs should confirm the flight schedules and the regulations for epidemic prevention of both import and export countries before arranging the pick-up date of the products to ensure the process of the donation is smooth and timely.
Using dry shipper, BTCSCC provides cryopreserved product of PBSCs and lymphocytes. For further information please contact coordinators of BTCSCC.
TC must report the product receipt form to BTCSCC in order to understand the status of the product and its recipient.
Thailand Thai National Stem Cell Donor Registry - TSCDR (ION-8362)
- Registry operational information available on: https://share.wmda.info/x/wxRcAQ
- Update July 7, 2020: TSCDR operation during COVID-19
- Search: TSCDR accept search request from transplant centres and registries as usual without restriction
- CT and WU requests: TSCDR has implemented COVID-19 donor eligibility criteria according to WMDA recommendation. Additional COVID-19 infection risk information have been required from donor as following, 1) risk of infection from working area such as airport staff, tour guide, airport staff, tour guide, medical staff etc. 2) risk of infection from close contact to infected person or person who come back from high risk countries 3) participate in activities with a lot of people or big communities. Donor who have above risk will be requested for temporary deferral for at least 28 days. Donor who pass medical assessment must be educated to quarantine themselves for protective COVID-19 infection before collection and must notify TSCDR if they found any symptoms related to COVID-19 infection during 14 days after collection. Some of collection centers are COVID-19 treatment centers affect decreasing collection facilities then the collection schedules may be delay.
- Transportation of blood samples: TSCDR do not find the delay of blood samples transportation with FedEx. Some donors may be requested to quarantine for 14 days that affect delay sample shipment schedule.
- Travel restrictions: The Government of Thailand has announced the Notification on Conditions for Aircraft Permission to Enter Thailand (No.2) on 2nd July 2020 affect the available flights for passengers coming to Thailand. Then cryopreservation of stem cell product was required and shipped by cargo flights.
Turkey - TRAN and TRIS (ION-5509 and ION-3893)
- Update March 20, 2020 : INFORMATION TRAN and TRIS would like to inform that as of today 14/03/2020, the Turkish Ministry of Health has decided to require all returning passengers (citizens and non-citizens) from all to adhere to a 14-day quarantine from their entry into Turkey. These provisions mean that foreign couriers will not be able to enter the country. It is also very likely that the frequency of flights to and from Turkey will decrease significantly in the coming days. TRIS and TRAN working very hard with competent authorities to find suitable solutions for each transport during next week, and we are in close contact with the relevant registries. However, due to this difficult situation, we can no longer guarantee a safe arrival of the product in the coming weeks.
- Search: TRIS and TRAN accepts search request from transplant centres and registries as usual, without any restrictions.
- Confirmatory Typing: Requests will be accepted as usual, but collection of a new blood sample for confirmatory typing has become more difficult day by day. Testing of provided samples are still in progress. For foreign registries, we suggest to request for on-site CT instead of requesting for a blood sample.
- Workup Requests: We will not be able to collect any cell product during this period. We are trying to complete the scheduled ones but we will not accept any WU request in this period.
- Transport of HPC collected on international donors: Most flights have been cancelled, so it is even more difficult to organize the transports of HPCs. We would suggest to arrive in Istanbul airport and we may assist with our courier in order to have the handover of the product directly at the airport.
- As March 19 The government close the air connection with 22 countries and close 3 borders. This countries are: China, Iran, Italy, Iraq, South Korea, Germany, France, Spain, Norway, Denmark, Belgium, Sweden, Netherlands, Austria, Egypt, United Kingdom, Switzerland, Saudi Arabia, Ireland, the United Arab Emirates, Greece, Bulgaria. The closed borders are with Iraq, Iran and Georgia. In this condition we can no longer guarantee a safe arrival of any blood sample in the coming weeks.
- Postpone donation : According to the novel coronavirus – guidance of WMDA, it is recommended to postpone donation in case of donors coming from risk area, or contacting with confirmed case, or with history of COVID-19 infection.
- Please contact in case of an emergency situation :
January 20, 2021: United Kingdom, UK aligned registries - guidance for international stem cell couriers entering the UK to deliver or collect stem cell products, click here.
United Kingdom, Anthony Nolan (ION-6354)
- Registry operational information available on: https://share.wmda.info/x/7RRcAQ
- Update May 22, 2020: On Friday 22nd May the UK government announced new measures at the UK borders to guard against a second wave of coronavirus infections, effective from 8th June. They include 14 days’ self-isolation for anyone entering the UK, bar a short list of exemptions. The exemptions include certain medical staff and we expect that this will include medical couriers. We have been in regular contact with the UK Department of Health and Social Care and are awaiting confirmation of what, if any, additional paperwork will be required for couriers entering the UK from 8th June onwards.
- Update July 29, 2020:
- Search: Anthony Nolan is accepting search requests from transplant centres and registries as usual
- VT requests: R equests will be accepted as usual and we are procuring blood samples . All donors are asked about travel history, upcoming travel and exposure to COVID-19. Donors will deferred as per guidelines.
- Workup requests: All donors are asked about travel history, upcoming travel and exposure to COVID-19. Donors will deferred as per guidelines, but donation can be considered if the transplant is urgent, there is no other donor available and the donor is well, with no symptoms. We are in the process of securing access to COVID-19 testing for at-risk donors in the UK. UK guidance to transplant centres now recommends considering cryopreservation for all collections.
- Transport: New regulations on entering the UK, due to coronavirus (COVID-19), came into effect on 7th July 2020 and apply to both residents and non-residents. These regulations mean that visitors:
- Will need to provide journey and contact details prior to travelling to the UK, via the Public Health passenger locator form: https://visas-immigration.service.gov.uk/public-health-passenger-locator-form
- Will be required to “self-isolate” (i.e. not be allowed to leave the place they are staying) for the first 14 days they are in the UK, except in very limited situations or where country exceptions apply (from 10th July 2020 and subject to change). International stem cell couriers (both importing and exporting) are exempt from this self-isolation period and will be provided with a letter stating this prior to travel by the organising registry.
Anthony Nolan staff are now predominantly working from home, but there is no change to our contact information or service to international registries.
United Kingdom British Bone Marrow Registry (ION-2731)
- Registry operational information available on: https://share.wmda.info/display/WMDAREG/ION-2731#/
- Update April 17, 2020:
- Search: We are continuing to accept search requests from transplant centres and registries as usual.
- VT requests: For all new requests after the 13th April, we will only draw blood samples under a limited set of circumstances. We will contact the donor to assess their health status, availability and willingness to donate. If the donor is available, we will ask if you would like us to carry out any additional HLA from stored DNA. If DNA is unavailable, we will only bleed the donor (to provide you with a VT sample and for IDM testing) if the donor’s HLA is of a poor quality (which we define as a less than second field resolution at HLA-A, -B, -C, -DRB1 and –DQB1). Where we are unable to provide samples, you will be able to request this at work-up.
- ET requests: For all new requests after the 13th April, we will only carry out extended typing from stored DNA. If this is not available, we will not draw a sample from the donor.
- Workup requests:We accept such requests as normal. If a donor has had a suspected COVID-19 infection, the current UK guidelines recommend waiting for three months after symptoms abate before commencing with G-CSF injections – this period can possibly be reduced in urgent cases. Please request PBSC donations rather than BMH where possible, We continue to accept lymphocyte requests, but we will prioritise access to apheresis slots for PBSC donations. As at the 13th April, we have COVID-19 testing available at one of our Collection Centres and expect to have this for all of them by the end of April – please ask for the current status. All exported products will be transferred to the Handover Hub (run by our esteemed colleagues at Anthony Nolan) for handover to your courier at London Heathrow airport. UK guidance to transplant centres now recommends considering cryopreservation for all collections; if necessary, we can arrange to cryopreserve at our Collection Centre then ship.
United Kingdom Welsh Bone Marrow Donor Registry (ION-6354)
- Registry operational information available on: https://share.wmda.info/display/WMDAREG/ION-1726#/
- Update June 8, 2020:
- From 8thJune the UK government has introduced a 14 day quarantine period for any person entering the UK. There is an exemptions to this rule that allows imported stem cells to continue to be brought into the UK by the designated courier and allows travel directly to the WBMDR to handover as usual. However for stem cells leaving the UK there is no current exemption for the courier to enter and travel to receive the cells. In these cases the WBMDR will use the ‘Handover HUB’ at Heathrow airport for the export of stem cells.
- Update April 16, 2020:
- Search: The WBMDR is continuing to accepting search requests from transplant centres and registries as usual.
- VT requests:In line with public health guidance on social distancing and to safe guard donors whilst ensuring that donor selection standards are met, the WBMDR has implemented a new algorithm for the provision of blood samples at CT. The ability of the donor to provide blood samples will be determined on a case by case basis and every effort will be made to provide a blood sample from those donors who are CMV negative or unknown. However, if a donor is unwilling / unable to give blood samples due to ‘social distancing’ measures the WBMDR can perform a health screening and availability questionnaire. Donors will then be required to give blood samples to test Infectious disease markers if they are chosen as the primary donor before stem cell collection.
- Workup requests:To clarify risk of infection WBMDR donor screening questionnaires have been extended to include questions relating to donor history of contact with COVID-19, symptoms, travel risks and vulnerable persons living with the donor (JPAC guidelines). The transplant centre will be notified immediately of any perceived risks. COVID-19 testing of WBMDR donors will take place at pre-collection (medical assessment) and on day of collection in response to updated NICE and EBMT guidance.
- Transport:For import of stem cells for Welsh Patients: The WBMDR uses an approved international courier. Many countries have already approved entry and exit of these specific couriers into their respective countries. Restrictions in air travel to and from countries is being updated daily and we are working with our UK Aligned Registry partners to determine the best method for ensuring we can transport stem cells to Heathrow and outside of the country. The WBMDR is in the process of updating its HTA license to include the import and export of cryopreserved cells. This will require the WBMDR to extend its existing process for assessment of international to include stem cell processing laboratories.
- Cryopreservation of products: Patients should not begin pre-transplant preparative regimens until the cells have arrived at the requesting transplant centre. In the majority of cases cells will be transported fresh for cryopreservation by the requesting transplant centre. Cells may then be stored for a quarantine period of 7 days to ensure that the donor is not infected with COVID-19. Cryopreservation at the collection centre will only be performed in exceptional circumstances where transport of fresh cells is not possible due to transit times exceeding 72 hours.
United States Be The Match-NMDP Registry (ION-3553)
United States Gift of Life Registry (ION-1033)
- Registry operational information available on: https://share.wmda.info/x/IRVcAQ
- Update 27 March, 2020: Gift of Life has made the following procedural changes and enhancements in light of COVID-19:
- All Confirmatory Typing requests will not have a blood sample drawn for CT and IDM testing as routinely performed. Cooperative Registries will be notified of the donor availability and health history screening outcomes. In the event a transplant center wants a CT performed, we are happy to oblige by sending the donor a buccal swab kit and having it typed at a laboratory different than the original typing laboratory. The sample can be run STAT. Please notify firstname.lastname@example.org if you have a special request.
- Gift of Life is asking all transplant centers not to condition patients until after the product is received. This will require transplant centers to cryopreserve the product on receipt. In the event a transplant center is unable to cryopreserve, Gift of Life can arrange for this to be done for donors collected at the Gift of Life – Be The Match Collection Center (please check with your Gift of Life coordinator upon submission of the workup request, and we will do our best to have the donor collected at our facility). Gift of Life will then arrange for the product to be shipped in a dry shipper to the destination transplant center.
- We are especially grateful to our colleagues at Ontime Onboard Courier GmbH - especially Thilo Buerklin - for making courier transport miracles happen! Thank you to the entire registry and transplant community – and to the WMDA office – our global community is coming together to beat this crisis and help the patients who count on us all.