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• A patient registration embedded block is sent together with each request. This block contains both the wmdaId and the patientId of the patient.

• Next to the actual request information, whenever the institutions are needed, they are sent explicitly as an Embedded Address Block.

• The requested donor has to be reserved at the remote hub and reported back to the requesting registry by an embedded donor block with the donor status reflecting the change (a.k.a. DONOR_CB with D_STATUS = ”RS”).

• All changes in the donors (change of status, updated typing, or IDMs) resulting from the requests are reported back in an embedded donor block. A separate update must be made to the Search & Match system with the updated donor data to ensure up-to-date master data. More information on how to do so may be found here.
• ReferenceCode: In order to couple messages to the same request, e.g. Sample Request and its results, all messages following the initial request must have a referenceCode as part of the message.

  • The message ID (correlationGuid) of the request message is used as the referenceCode for the rest of the request related message flow.

• Each field inherited from EMDIS Semantics contains a comment describing its purpose in EMDIS and its original name to assist in the transition from EMDIS to Match-Connect.
• Paragraph Request + Response Flows depicts the new message flows.

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• Intermediate resolution (M) translates to the non-high resolution.
• The coding schema theoretically allows more combinations than the previous bitstring (e.g. non-high DRB1 typing). The actually valid combinations have to be published in the national rules of each registry. The local user interfaces will have to take care that no invalid or previously undefined requests are issued.
• Combinations are possible, i.e. several loci may be requested in one message.
• The appropriate action if the typing request cannot be accepted or has to be changed by the by the recipient, e.g. due to national rules, is to inform the requesting side what was done. If only the only the resolution was changed (the sender will receive something different than ordered - either more either more or less) or only a part of the requested loci were accepted (the sender will only receive parts receive parts of what was ordered): send a an MSG_RSP containing the warning.

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• The fields ”earliest and latest date of sample reception” represent the lower and upper limit of a the period of time in which the blood sample has to be received. If the second date is missing, the sample may be received any time after the first date.
• The quantity for the first product is optional when requesting DNA from a cord blood unit. In all other requests, the quantity fields for any of the corresponding product fields are required if a product is requested.
• Number A number of tubes requested in a sample request or marrow request:
  • The maximum amount of material, requested in one sample request or pre-collection sample request , is 100 ml, if not stated otherwise in the national rules.
  • If the number of tubes is unassigned, and not given in the request, the default value number of tubes is one.

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• The message can only be exchanged in one direction: from the donor side to the patient side.
• Sample information is always referencing a sample request.
• Sample information is only valid as long as the referenced sample request is considered as ”open” and the donor is reserved for this patient after the sample request.
• A request is considered as ”open” considered”open” as long as the patient patient registry has neither reported the sample results nor a Request Rejected message nor a request cancellation.
• There might be several sample information messages within the context of one sample request. Subsequent sample information is regarded as new or additional information and not as updates.

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• donorStillOfInterest = ”N” means: the donor can be released immediately.
• donorStillOfInterest = ”Y” means: please prolong donor reservation according to your national rules.
• The fields for the infectious disease markers are included in this message in order to give the transplant centers the possibility to report the results of IDMs they might have tested.
• If Sample Results cannot be sent then a Request Rejected message should be sent with the reason field populated to explain why.

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Rules

• The common use of the IDM Results message is in response to the Sample Request message, in addition to shipment of the donor blood sample. Please note there may be a charge involved with this service. If a fee is charged, it may come as a separate item or might be included in the price of the sample shipment. Such IDM Results messages can be sent via a regular EMDIS message - the remote hub must be able to handle it appropriately. The IDM Results must have the same referenceCode as the Sample Request message.
• IDM Results message can be generated in response to two different message requests:
  • Sample Request does not specify what set of infectious disease markers to be tested
  • IDM Request does specify what set of infectious disease markers to be tested
• The field marker is a required field.
• For those hubs reporting infectious disease markers during verification typing, the marker field should contain the IDMs actually tested. There is a fixed-length binary field for the IDM Results message. The blood group may also be also reported.
• IDM results can also be also reported as a part of the Sample Results message by the hub (transplant center) that requested the blood sample. This is to give the transplant centers the possibility to report the results of IDMs they might have tested.

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5.11 - Donor Release Request (new message)

This message is sent by the The patient registry sends this message to inform the donor registry that a donor can be released from the reservation when it is no longer needed (e.g. patient is deceased or was transplanted with another donor). This should be used if the donor reservation was confirmed in a response to some request. If the reservation has not been confirmed then a Request Cancellation message should be used.

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This message is used to cancel a previous request that has been sent to the donor registry. The Request must have a preceding request that is being cancelledcanceled.

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