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Missing:
Listing a donor (+ definition of temporary unavailable donors)
MNC, check ISBT 128 standard
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Hematopoietic progenitor cells (HPC): Immature blood cells that are restricted in their ability to differentiate and lack the capacity self-renewal in compared to HSC.
Hematopoietic stem cells (HSC): Immature blood progenitor cells that give rise to all cells of the blood and immune systems including red blood cells, white blood cells, and platelets. In contrast with HPC, these cells demonstrate a capacity for self-renewal and potential to produce all types of blood cells. HPC are found in bone marrow, peripheral blood, and umbilical cord blood.
Human Leukocyte Antigen (HLA): Large, evolutionarily conserved complex of genes also known as the major histocompatibility complex (MHC). Located on the short arm of chromosome six, HLA genes are imperative to immune function in humans. A subset of HLA genes whose products include antigen-presenting molecules present on cell surfaces are considered when determining a donor’s suitability for transplant; degree of HLA match between donor and recipient is the largest determinant of post-transplant outcome.
Hybrid Cord Blood Banking: A CBB business model whereby privately banked CBU are included among public inventory; hybrid CBU are thus searchable on behalf of unrelated patients in need of HSCT. If a hybrid CBU is identified as a possible candidate for transplant, the CBB must investigate whether the person for whom the unit was privately collected would be willing to release the unit for unrelated transplant.
ISBT 128: Global Information Standard for Medical Products of Human Origin: ISBT 128 is the global standard for the terminology, identification, coding and labeling of medical products of human origin. The standard has been designed to ensure the highest levels of accuracy, safety, and efficiency for the benefit of donors and patients worldwide by providing international consistency to support the transfer, traceability and transfusion/transplantation of blood, cells, tissues, and organs.
Issuing Organisation Number (ION): Four-digit number between 1000 and 9999 assigned to an organisation that issues GRID to adult unrelated stem cell donors. Assigned by ICCBBA in its capacity as an issuing agency under ISO 15459, the ION is encoded and interpreted by reference to the ICCBBA GRID Issuing Organization Number Table published and maintained by ICCBBA. The ION comprises the first 4 characters of a GRID.
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Major Histocompatibility Complex: Large, multigene complex of polymorphic genes encoding components of the of adaptive immune system across vertebrate species; also known as HLA in humans (see above).
Mononuclear cell (MNC) apheresis: Apheresis collection of donor lymphocytes for DLI infusion (see above)
Nomenclature: A system of naming in arts or science.
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Serology: The scientific study of plasma serum and other bodily fluids. Applications of serology in HSCT include HLA typing and identification of anti-HLA antibodies (alloimmunization) in patients.
Search status: Refers to the current search status of an HPC product with the options: AV = Available for transplantation purposes, TU = Temporarily unavailable, RS = Reserved, DE = Deleted/permanently unavailable.
Total nucleated cell count (TNC): The number of immature blood cells present in a cord blood unit. This value could be presented pre-freeze or post-thaw and is required to establish whether a CBU would provide the requisite cell dose for a patient seeking cord blood transplant.
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