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Adult Donor Cryopreserved Unit (ADCU): An unrelated adult donor-derived HSC product (generally PBSC) that is cryopreserved (frozen) prior to transplant. These donations are not collected on behalf of a specific patient (undirected donation); products are available on behalf of any patient seeking transplant, may be searched alongside donor and CBU options, and offer an expedited path to transplant.
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Hematopoietic progenitor cells (HPC): Immature blood cells that are restricted in their ability to differentiate and lack the capacity self-renewal in compared to HSC.
Hematopoietic stem cells (HSC): Immature blood progenitor cells that give rise to all cells of the blood and immune systems including red blood cells, white blood cells, and platelets. In contrast with HPC, these cells demonstrate a capacity for self-renewal and potential to produce all types of blood cells. HPC are found in bone marrow, peripheral blood, and umbilical cord blood.
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Hybrid Cord Blood Banking: A CBB business model whereby privately banked CBU are included among public inventory; hybrid CBU are thus searchable on behalf of unrelated patients in need of HSCT. If a hybrid CBU is identified as a possible candidate for transplant, the CBB must investigate whether the person for whom the unit was privately collected would be willing to release the unit for unrelated transplant.
ISBT 128: Global Information Standard for Medical Products of Human Origin: ISBT 128 is the global standard for the terminology, identification, coding and labeling of medical products of human origin. The standard has been designed to ensure the highest levels of accuracy, safety, and efficiency for the benefit of donors and patients worldwide by providing international consistency to support the transfer, traceability and transfusion/transplantation of blood, cells, tissues, and organs.
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