Condition
History of previous hepatitis B infection
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Individual at risk
Recipient
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Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation)
Acceptable if more than 12 months have past since infection, and the donor has documented Anti-hepatitis B surface antibody >100iu/L.
Guidance at CT/WORK-UP
If less than 12 months since recovery from acute infection, defer.
If more than 12 months from recovery, obtain history and blood samples.
Donors with a definite or possible previous history of hepatitis B (whether known or not) may be accepted if:
Donor is negative for all markers
OR
Donor is hep B core antibody positive, heb B surface antigen negative and hep B surface antibody has been documented to be more than 100 iu/l at some time.
Inform requesting transplant centre if donor history or serological markers suggest a previous hepatitis B infection.
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Justification for guidance
Hepatitis B infection is transmissible by transfusion of blood and stem cells.
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Notes
This advice is a requirement of the EU Tissues and Cells Directive.
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