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This page was last modified on 20 August 2013, at 13:12.

Condition

An abnormal reduction in bone mineral density associated with an increased risk of fractures. The most common aetiology relates to post-menopausal reductions in circulating oestrogen, and as such this condition far more commonly affects females.

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Individual at risk

Donor

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Guidance at RECRUITMENT

Establish cause, and if not otherwise excluded may join.

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Guidance at CT/WORK-UP

Establish cause, and if not otherwise excluded may donate by PBSC only. Inform requesting transplant centre that donor is PBSC only.

Hormone replacement therapy for post-menopausal females is usually not derived from human tissues, and therefore acceptable in this context.

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Justification for guidance

Shearing stresses applied to the pelvis and lower spine during bone marrow harvest may be a particular risk in donors with osteoporosis.

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References

Gladden K, Spill GR. Iliac fracture after a bone marrow biopsy. Pm R 2011; 3(12): 1150-2.

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