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titlebasicTypes.xsd
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languagexml
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firstline1059
titleVersion 2.2
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<xs:sequence>
			<xs:element name="A" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="B" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="C" type="hlaLocusType" minOccurs="0"/>
            <xs:element name="DRB1" type="hlaLocusType" minOccurs="0"/>


  • Add HLA-E after HLA-C, HLA-E only has DNA fields
  • For the type change of "A", "B", "C" and "DRB1", please check the change of 


Code Block
languagexml
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titleVersion 2.3
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<xs:sequence>
			<xs:element name="A" type="hlaLocusTypehlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="B" type="hlaLocusTypehlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="C" type="hlaLocusTypehlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="E" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB1" type="hlaLocusTypehlaLocusSerDnaType" minOccurs="0"/>


XML Example to add the HLA-E:

Code Block
languagexml
<HLA>
	<A>...</A>
	<B>...</B>	
	<E>
		<DNA>
			<FIELD1>01:01:01:01</FIELD1>
			<FIELD2>01:01:01:02</FIELD2>
		</DNA>
	</E>
</HLA>



...

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titlebasicTypes.xsd
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languagexml
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titleVersion 2.2
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			<xs:element name="DRB1" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="DRB3" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB4" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB5" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQB1" type="hlaLocusType" minOccurs="0"/>
			<xs:element name="DPA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DPB1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
		</xs:sequence>


  • Add fields MICA and MICB as part of HLA
    - Added a new type "hlaLocusGlsOnlyType" for MICA and MICB

     Because of the request to add MICA and MICB, we see issues with naming of the existing schema type for HLA, so some improvements are made.

  • Change the type of "hlaLocusType" to "hlaLocusSerDnaType" (XSD structure optimization, no effect to XML structure)
  • Additionally 3 new schema types are added:
    - simpleType "hlaGlsFieldType"
    - complexType "hlaLocusGlsOnlyType"
    - complexType "hlaLocusSerDnaType"

     Check below the "XSD schema type naming optimization" for more details for the type changes in the code below.


Code Block
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			<xs:element name="DRB1" type="hlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="DRB3" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB4" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DRB5" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DQB1" type="hlaLocusSerDnaType" minOccurs="0"/>
			<xs:element name="DPA1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="DPB1" type="hlaLocusDnaOnlyType" minOccurs="0"/>
			<xs:element name="MICA" type="hlaLocusGlsOnlyType" minOccurs="0"/>
			<xs:element name="MICB" type="hlaLocusGlsOnlyType" minOccurs="0"/>
		</xs:sequence>


XML example to use MICA:

<xs:simpleType name="hlaGlsFieldType"> <xs:annotation> <xs:documentation xml:lang="en">HLA typing result provided as GL String</xs:documentation> </xs:annotation> <xs:restriction base="xs:string"> <xs:maxLength value="255"/> </xs:restriction> </xs:simpleType> <xs:complexType name="hlaLocusBaseType">
Code Block
languagexml
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titleVersion 2.3
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<HLA>
	<A>...</A>
	<B>...</B>	
	<DPB1>...</DPB1>
	<MICA>
		<GLS>008:01:01/008:01:02/008:03/008:04+018:01/018:02</GLS>
	</MICA>
</HLA>

XSD schema type naming optimization


Panel
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titlebasicTypes.xsd
Panel
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titlebasicTypes.xsd
Code Block
languagexml
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titleVersion 2.32
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	   <xs:complexType name="hlaLocusSerDnaTypehlaLocusType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising SER and DNA fields</xs:documentation>
		</xs:annotation>
					<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
   				<xs:sequence>
					<xs  				   				 										 				 																									  
		<xs:sequence>
			<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="0"/>
											</xs:sequence>
			</xs:restriction>  
		</xs:complexContent>sequence>
	</xs:complexType>
Code Block

Because of the request to add MICA and MICB, we see issue with naming of the schema type for HLA fields, so some additional improvements are made as below:

  • General "hlaLocusType" is improved to "hlaLocusBaseType"
  • Add GLS field with type "hlaGlsFieldType" in the "hlaLocusBaseType"


Code Block
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titleVersion 2.3
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	    <xs:complexType name="hlaLocusGlsOnlyTypehlaLocusBaseType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus base type comprising a GL String only<SER, DNA and GLS fields</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
				<xs:sequence>
					<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="01"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="01"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="1"/>
				</xs:sequence>
			</xs:restriction>
		</xs:complexContent>
	</xs:complexType>

Additional improvement to XSD structures:

complexType>


  • Change the type of "hlaLocusType" for locus to "hlaLocusSerDnaType" (XSD structure optimization, no effect to XML structure)
  • Additionally 3 new schema types are added:
    - simpleType "hlaGlsFieldType"
    - complexType "hlaLocusGlsOnlyType"
    - complexType "hlaLocusSerDnaType
  • "hlaLocusType" is improved to "hlaLocusBaseType"
  •  Add GLS field with type "hlaGlsFieldType"
Code Block
languagexml
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titleVersion 2.23
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   <xs:complexType name="hlaLocusType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising SER and DNA fields</xs:documentation>
		</xs:annotation>								   							  				   				 										 				 																									  
		<xs:sequence>
			<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
			<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>																			  
		</xs:sequence>
	</xs:complexType>
Code Block
languagexml
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titleVersion 2.3
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    <xs:complexType name="hlaLocusBaseType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus base type comprising SER, DNA and GLS fields</xs:documentation>
		</xs:annotation>
		<xs:sequence>
			<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
			<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>	<xs:simpleType name="hlaGlsFieldType">
		<xs:annotation>
			<xs:elementdocumentation namexml:lang="GLSen" type="hlaGlsFieldType" minOccurs="0" maxOccurs="1"/>
		</xs:sequence>
>HLA typing result provided as GL String</xs:documentation>
		</xs:complexType>

XML example to use MICA:

Code Block
languagexml
<HLA>
	<A>...</A>
	<B>...</B>	
	<DPB1>...</DPB1>
	<MICA>
		<GLS>008:01:01/008:01:02/008:03/008:04+018:01/018:02</GLS>
	</MICA>
</HLA>

XSD schema type naming optimization

annotation>
		<xs:restriction base="xs:string">
			<xs:maxLength value="255"/>
		</xs:restriction>
	</xs:simpleType>
	<xs:complexType name="hlaLocusBaseType">
Code Block
languagexml
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titleVersion 2.23
linenumberstrue
   	<xs:complexType name="hlaLocusTypehlaLocusGlsOnlyType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus type comprising SER and DNA fields</xs:documentation>
		</xs:annotation>								   							  				   				 										 				 																									  
"en">HLA locus type comprising a GL String only</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
				<xs:sequence>
					<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="10"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="10"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="1"/>
														  </xs:sequence>
			</xs:sequence>restriction>
		</xs:complexType>

Because of the request to add MICA and MICB, we see issue with naming of the schema type for HLA fields, so some additional improvements are made as below:

  • "hlaLocusType" is improved to "hlaLocusBaseType"
    •  Add GLS field with type "hlaGlsFieldType" in the "hlaLocusBaseType"
    complexContent>
	</xs:complexType>
    Code Block
    languagexml
    themeRDark
    firstline10611051
    titleVersion 2.3
    linenumberstrue
        	<xs:complexType name="hlaLocusBaseTypehlaLocusSerDnaType">
		<xs:annotation>
			<xs:documentation xml:lang="en">HLA locus base type comprising SER, DNA and GLSDNA fields</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:restriction base="hlaLocusBaseType">
				<xs:sequence>
					<xs:element name="SER" type="hlaSerFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="DNA" type="hlaDnaFieldsType" minOccurs="0" maxOccurs="1"/>
					<xs:element name="GLS" type="hlaGlsFieldType" minOccurs="0" maxOccurs="10"/>
				</xs:sequence>
			</xs:restriction>
		</xs:complexContent>
	</xs:complexType>