Timeline

Proposal ready:

31 Aug 2021

XSD Approval

22 Feb 2022

XSD public review

04 Mar 2022 - 04 May 2022

Implementation / testing

2024 Q3, Q4

Release Date

2025 Q1

Planned Retire Date

TBD

Status

Progress Bar | Vectors (Formerly: SP Progress bar)

current-step	4
steps	Preparation, Draft, Discussion, Public review , Implementation, Release

Table of Contents

Introduction

XSD 2.4 includes quite a lot of changes for RFCs as below:

RFC-007: more fields to distinguish IDM-tests (HBV, HCV, HEV, West Nile Virus and Chagas)

RFC-008: Introduction of Adult Adult Donor Cryopreserved Unit (ADCU)

RFC-009 R2sh-CBU fields request

RFC-010 CBU Viability for Multiple Cell Types

RFC-012 Change of Collection Volume Field from Integer to Real Number

Another important update which effect the XML structure is the flat to nested structure change. This change will change and improve fields of post-collection, post-processing and new fields for post-thaw.

Any question or comments are welcome. You can ask question regarding XSD 2.4 here : https://share.wmda.info/questions/topics/403341316/xsdv24 or send email to support@wmda.info.

For members who have account in share and are interested to check the details of the discussion of the changes, you can check the internal meeting notes for XSD 2.4 in the link: https://share.wmda.info/x/agztFQ.

Info
Please notice that XSD 2.3 change of GRID/ID must be implemented as well if upgrade to XSD 2.4 directly from XSD 2.2

Download XSD schema version 2.4

Below are the example XML files and the .xsd files.

Attachments

Changes between version 2.4 and 2.3

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title	Inventories.xsd

Updated version number to 2.4

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<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" elementFormDefault="qualified" attributeFormDefault="unqualified" version="2.4">

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language	xml
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title	Version 2.3
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<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" elementFormDefault="qualified" attributeFormDefault="unqualified" version="2.3">

Panel

RFC 007 IDM changes

XSD schema doc changes

Add new fields ANTI_HEV, HEV_NAT, CHAGAS_NAT
Rename fields WMV to WNV_NAT, CHAGAS to ANTI_CHAGAS
Update order of fields HCV_NAT and HBV_NAT

Code Block

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			<xs:element name="ANTI_HBS" type="idmValueType" minOccurs="0">
				<xs:

Panel

RFC 008 Add whole ADCU structure

XSD schema changes

Change the documentation

Add "ADCU" related description for the fields that used in ADCU product.

Code Block

language	xml
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			<xs:element name="BIRTH_DATE" type="bareDateType">
				<xs:annotation>
					<xs:documentation xml:lang="en">Date of birth of the donor/donor of ADCU/child of CBU</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="SEX" type="sexType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Biological gender of the donor/ADCU/CBU. Mandatory for donors, optional for CBUs.</xs:documentation>
				</xs:annotation>
			</xs:element>

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title	Version 2.3
linenumbers	true

			<xs:element name="BIRTH_DATE" type="bareDateType">
				<xs:annotation>
					<xs:documentation xml:lang="en">Date of birth of the donor/CBU</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="SEX" type="sexType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Biological>Hepatitis genderB ofstatus the donor/CBU. Mandatory for donors, optional for CBUs.(antibody to hepatitis B surface antigen)</xs:documentation>
				</xs:annotation>
			</xs:element>

Add new item type unitItemBaseType

This item will extend the itemBaseType and include the shared fields of ADCU and CBU.

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			<xs:complexTypeelement name="HBV_NAT" type="idmValueType" minOccurs="unitItemBaseType0">
				<xs:annotation>
					<xs:documentation>Abstract base type for banked unit items (ADCU, CBU)<documentation xml:lang="en">HBV NAT status</xs:documentation>
				</xs:annotation>
			<xs</xs:complexContent>element>
			<xs:extensionelement basename="itemBaseType">
ANTI_HCV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:sequence>
		:documentation xml:lang="en">Hepatitis C status (antibody to hepatitis C virus)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HCV_NAT" type="idmValueType" minOccurs="ID0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Unique>HCV identifier of the unit: For CBUs: The value comprises the EMDIS hub code + donor identification allocated by the associated donor registry, where the sending organisation is an EMDIS member, otherwise the two digit ISO country code of the associated donor registry + donor identification allocated by the associated donor registry. For example: AU600196166, DEGOE-35487, US087013165, SB45. For ADCUs: ISBT 128 DIN without flag and check characters. for example: A999914123456</xs:documentation>
						</xs:annotation>
						<xs:simpleType>

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	<xs:complexType name="cbuItemType">
		<xs:annotation>
NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HEV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis E status (antibody to hepatitis E virus)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HEV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HEV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HIV_12" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">A CBU (cord blood unit) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.</xs:documentation>
		</xs>Anti-HIV 1/2 status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HIV_1_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
		<xs:complexContent>
			<xs:extensiondocumentation basexml:lang="unitItemBaseType">en">HIV-1 NAT status</xs:documentation>
				<xs</xs:sequence>annotation>
			</xs:element>
			<xs:element name="COLLHIV_DATEP24" type="bareDateTypeidmValueType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Date>HIV that the unit was collected<p24 status</xs:documentation>
						</xs:annotation>
					</xs:element>

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			<xs:complexTypeelement name="cbuItemTypeANTI_HTLV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">A>Antibody cordto blood unit (CBU) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.<HTLV I/II</xs:documentation>
				</xs:annotation>
			<xs</xs:complexContent>element>
			<xs:extension base="itemBaseTypeelement name="SYPHILIS" type="idmValueType" minOccurs="0">
				<xs:sequence>annotation>
					<xs:element name="IDdocumentation xml:lang="en">Syphilis status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="WNV_NAT" type="idmValueType" minOccurs="10">
						<xs:annotation>
							<xs:documentation xml:lang="en">Unique>WNV identifier of the CBU: The value comprises the EMDIS hub code + donor identification allocated by the associated donor registry, where the sending organisation is an EMDIS member, otherwise the two digit ISO country code of the associated donor registry + donor identification allocated by the associated donor registry. For example: AU600196166, DEGOE-35487, US087013165, SB45.<NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_CHAGAS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Chagas antibody status</xs:documentation>
						</xs:annotation>
						<xs:simpleType>
				</xs:element>
			<xs:restriction base="xs:stringelement name="CHAGAS_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:maxLengthdocumentation valuexml:lang="25en"/>
			>Chagas NAT status</xs:documentation>
				</xs:restriction>annotation>
						</xs:simpleType>element>
					</xs:element>

Add adcuItemType

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	<xs:complexType name="adcuItemType">
<xs:element name="EBV" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">An ADCU (adult donor cryopreserved unit) is a banked, frozen blood product collected from an adult donor.</xs>EBV status</xs:documentation>
				</xs:annotation>
			<xs</xs:complexContent>element>
			<xs:extensionelement basename="unitItemBaseType">
				<xs:sequence>
					<xs:element name="COLL_DATE" type="bareDateType">
		TOXO" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
							<xs:documentation xml:lang="en">Date that the unit was collected<>Toxoplasmosis status</xs:documentation>
						</xs:annotation>
					</xs:element>

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					<xs<xs:element name="COLLANTI_TYPEHBS" type="idmValueType" minOccurs="collTypeType0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Collection type, i.e. the collection method used<>Hepatitis B status (antibody to hepatitis B surface antigen)</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POSTANTI_COLLHCV" type="postCollAdcuTypeidmValueType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Post>Hepatitis C collectionstatus (prior processing) data<antibody to hepatitis C virus)</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POSTANTI_HIV_PROC12" type="postProcAdcuTypeidmValueType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Post-processing (prior cryopreservation) data<:documentation xml:lang="en">Anti-HIV 1/2 status</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POSTHIV_1_THAWNAT" type="postThawAdcuTypeidmValueType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Post-thaw data<:documentation xml:lang="en">HIV-1 NAT status</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:group ref="nmbrFieldsGroup"/>
					<xs:element name="QAHIV_DATEP24" type="bareDateTypeidmValueType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Date>HIV of laboratory quality assessment<p24 status</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="HCV_NAT" type="idmValueType" minOccurs="GRID0">
						<xs:annotation>
							<xs:documentation xml:lang="en">GRID>HCV of the donor of the ADCU.<NAT status</xs:documentation>
						</xs:annotation>
			</xs:element>
			<xs:simpleType>
							<xs:restriction base="xs:stringelement name="ANTI_HTLV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:lengthdocumentation valuexml:lang="19"/>
							<en">Antibody to HTLV I/II</xs:restriction>documentation>
						</xs:simpleType>annotation>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>
	<xs:complexTypeelement name="SYPHILIS" type="inventoryType"idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Type representing an inventory of donors, ADCUs (adult donor unit) and/or CBUs (cord blood units)</>Syphilis status</xs:documentation>
				</xs:annotation>
			<xs</xs:sequence>element>
			<xs:element name="DONORWNV" type="donItemTypeidmValueType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:documentation xml:lang="en">A donor is an adult person who has consented to donate haematopoietic progenitor cells, that is, HPC(M) or HPC(A) and similar products to an unrelated patient.<>WNV status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ADCUCHAGAS" type="adcuItemTypeidmValueType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:documentation xml:lang="en">An ADCU (adult donor cryopreserved unit) is a banked, cryopreserved blood product collected from an adult donor.<>Chagas status</xs:documentation>
				</xs:annotation>
			</xs:element>

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			<xs:complexTypeelement name="EBV" type="idmValueExtType" minOccurs="inventoryType0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Type representing an inventory of donors and/or cord blood units (CBUs)<>EBV status</xs:documentation>
				</xs:annotation>
			<xs</xs:sequence>element>
			<xs:element name="DONORTOXO" type="donItemTypeidmValueExtType" minOccurs="0" maxOccurs="unbounded">
>
				<xs:annotation>
					<xs:documentation xml:lang="en">A donor is an adult person who has consented to donate haematopoietic progenitor cells, that is, HPC(M) or HPC(A) and similar products to an unrelated patient.<>Toxoplasmosis status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CBUHBV_NAT" type="cbuItemTypeidmValueType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:documentation xml:lang="en">A>HBV cord blood unit (CBU) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.<NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
		</xs:sequence>

(Impact XML format) Improve some flat structure to nested structure

Improved to use nested structure of POST_COLL (post collection), introduced item type postCollCbuType, postCollAdcuType, postCollBaseType

Improved to use nested structure of POST_PROC (post processing/pre-cryopreservation), introduced item type postProcCbuType, postProcAdcuType, postProcBaseType

Example of IDM XML

Added POST_THAW object. See details in the part for RFC 009 below

<xs:element name="POST_COLL" type="postCollAdcuType" minOccurs="0"> <xs:annotation> <xs:documentation xml:lang="en">Post collection (prior processing) data</xs:documentation> </xs:annotation> </xs:element> <xs:element name="POST_PROC" type="postProcAdcuType" minOccurs="0"> <xs:annotation> <xs:documentation>Post-processing (prior cryopreservation) data</xs:documentation> </xs:annotation> </xs:element>

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title	Version 2.4 Inventories.xsd
linenumbers	true

					<xs:element name="POST_COLL" type="postCollCbuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Post collection (prior processing) data</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POST_PROC" type="postProcCbuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Data of post-processing (prior cryopreservation)</xs:documentation>
						</xs:annotation>
					</xs:element>

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title	Version 2.4 Inventories.xsd
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<IDM>
    <ANTI_CMV>P</ANTI_CMV>
    <ANTI_CMV_DATE>2010-07-04</ANTI_CMV_DATE>
    <CMV_NAT>N</CMV_NAT>
    <CMV_NAT_DATE>2010-07-04</CMV_NAT_DATE>
    <HBS_AG>N</HBS_AG>
    <ANTI_HBC>N</ANTI_HBC>
    <ANTI_HBS>N</ANTI_HBS>
    <HBV_NAT>N</HBV_NAT>
    <ANTI_HCV>N</ANTI_HCV>
    <HCV_NAT>N</HCV_NAT>
    <ANTI_HEV>N</HEV_NAT>
    <HEV_NAT>N</HEV_NAT>
    <ANTI_HIV_12>N</ANTI_HIV_12>
    <HIV_1_NAT>N</HIV_1_NAT>
    <HIV_P24>N</HIV_P24>
    <ANTI_HTLV>N</ANTI_HTLV>
    <SYPHILIS>N</SYPHILIS>
    <WNV_NAT>N</WNV_NAT>
    <ANTI_CHAGAS>N</ANTI_CHAGAS>
    <CHAGAS_NAT>N</CHAGAS_NAT>
    <EBV>N</EBV>
    <TOXO>N</TOXO>
    <PB19_NAT>N</PB19_NAT>
    <ALT>1</ALT>
</IDM>

Panel

RFC 008 Add whole ADCU structure

XSD schema changes

Change the documentation

Add "ADCU" related description for the fields that used in ADCU product.

Code Block

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title	Version 2.4 basicTypes.xsd
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			<xs:complexTypeelement name="postCollBaseTypeBIRTH_DATE" type="bareDateType">
				<xs:annotation>
			<xs:documentation>Post-collection (prior processing) base data<		<xs:documentation xml:lang="en">Date of birth of the donor/donor of ADCU/child of CBU</xs:documentation>
				</xs:annotation>
			<xs</xs:sequence>element>
			<xs:element name="VOL"SEX" type="sexType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Collected volume (without additives) in ml<>Biological gender of the donor/ADCU/CBU. Mandatory for donors, optional for CBUs.</xs:documentation>
				</xs:annotation>
			</xs:element>

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	<xs:simpleType>
					<xs:restrictionelement basename="xs:floatBIRTH_DATE" type="bareDateType">
						<xs:minInclusive value="1.0"/>
	annotation>
					<xs:maxInclusivedocumentation valuexml:lang="9999.9"/>
					<en">Date of birth of the donor/CBU</xs:restriction>documentation>
				</xs:simpleType>annotation>
			</xs:element>
			<xs:element name="TNCSEX" type="xs:floatsexType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total>Biological numbergender of nucleated cells< the donor/CBU. Mandatory for donors, optional for CBUs.</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CD34PC" type="xs:float" minOccurs="0">

Add new item type unitItemBaseType

This item will extend the itemBaseType and include the shared fields of ADCU and CBU.

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	<xs:complexType name="unitItemBaseType">
		<xs:annotation>
					<xs:documentation xml:lang="en">Total number of CD34+ cells<documentation>Abstract base type for banked unit items (ADCU, CBU)</xs:documentation>
				</xs:annotation>
		<xs:complexContent>
			</xs:element>
		</xs<xs:extension base="itemBaseType">
				<xs:sequence>
	</xs:complexType>
					<xs:complexTypeelement name="postCollCbuTypeID">
						<xs:annotation>
			<xs:documentation>Post-collection (prior processing) data for CBUs</xs:documentation>
		</xs:annotation>
				<xs:complexContent>
			<xs:extension base="postCollBaseType"/>
		</xs:complexContent>
	</xs:complexType>
	<xs:complexType name="postCollAdcuType">
		<xs:annotation>
			<xs:documentation>Post-collection (prior processing) data for ADCUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postCollBaseType">
				<xs:sequence>
					<xs:element name="CD3PC" type="xs:float" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of CD3+ cells </xs:documentation>
						</xs:annotation>
documentation xml:lang="en">Unique identifier of the unit: For CBUs: The value comprises the EMDIS hub code + donor identification allocated by the associated donor registry, where the sending organisation is an EMDIS member, otherwise the two digit ISO country code of the associated donor registry + donor identification allocated by the associated donor registry. For example: AU600196166, DEGOE-35487, US087013165, SB45. For ADCUs: ISBT 128 DIN without flag and check characters. for example: A999914123456</xs:documentation>
						</xs:element>annotation>
				</xs:sequence>
			</xs:extension><xs:simpleType>
		</xs:complexContent>
	</xs:complexType>

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	<xs:complexType name="postProcBaseTypecbuItemType">
		<xs:annotation>
			<xs:documentation>Post-processing (prior cryopreservation) base data<:documentation xml:lang="en">A CBU (cord blood unit) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="unitItemBaseType">
				<xs:sequence>
					<xs:element name="COLL_DATE" type="VOLbareDateType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total volume in ml<>Date that the unit was collected</xs:documentation>
						</xs:annotation>
				<xs:simpleType>
					<xs:restriction base="xs:float">
						<xs:minInclusive value="1.0"/>
							</xs:element>

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	<xs:complexType name="cbuItemType">
		<xs:annotation>
			<xs:documentation xml:lang="en">A cord blood unit (CBU) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.</xs:documentation>
		</xs:annotation>
		<xs:complexContent><xs:maxInclusive value="9999.9"/>
					</xs:restriction>
				</xs:simpleType>
			</xs:element>
			<xs:elementextension namebase="CFU" type="xs:float" minOccurs="0"itemBaseType">
				<xs:annotation>sequence>
					<xs:documentation xml:lang="en">Total count of colony forming units</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="MNC" type="xs:floatID" minOccurs="01">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total>Unique Numberidentifier of mononucleatedthe cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="TNC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of nucleated cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="VIABILITY_TNC" type="viabilityType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding TNC</xs:documentation>
CBU: The value comprises the EMDIS hub code + donor identification allocated by the associated donor registry, where the sending organisation is an EMDIS member, otherwise the two digit ISO country code of the associated donor registry + donor identification allocated by the associated donor registry. For example: AU600196166, DEGOE-35487, US087013165, SB45.</xs:documentation>
						</xs:annotation>
						</xs<xs:element>simpleType>
							<xs:elementrestriction namebase="CD34PC" type="xs:float" minOccurs="0"string">
				<xs:annotation>
					<xs:documentationmaxLength xml:langvalue="en">Total number of CD34+ cells 25"/>
							</xs:documentation>restriction>
						</xs:annotation>simpleType>
					</xs:element>

Add adcuItemType

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			<xs:elementcomplexType name="VIABILITY_CD34PC" type="viabilityType" minOccurs="0adcuItemType">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding CD43+ cells</xs:documentation>
				</xs:annotation>
	>An ADCU (adult donor cryopreserved unit) is a banked, frozen blood product collected from an adult donor.</xs:documentation>
		</xs:element>
:annotation>
		<xs:complexContent>
			<xs:extension base="unitItemBaseType">
				<xs:sequence>
					<xs:element name="VIABILITYCOLL_CD45PCDATE" type="viabilityType" minOccurs="0bareDateType">
						<xs:annotation>
							<xs:documentation xml:lang="en">Viability>Date that informationthe regardingunit CD45+was cells<collected</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="REDCOLL_BCTYPE" minOccurstype="0collTypeType">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total>Collection number of nucleated red blood cells<type, i.e. the collection method used</xs:documentation>
						</xs:annotation>
				<xs:simpleType>
		</xs:element>
					<xs:restriction base="xs:floatelement name="POST_COLL" type="postCollAdcuType" minOccurs="0">
						<xs:minInclusive value="0.0E0"/>
annotation>
							<xs:maxInclusivedocumentation valuexml:lang="999.9E7"/>
en">Post collection (prior processing) data</xs:documentation>
						</xs:restriction>annotation>
				</xs:simpleType>
			</xs:element>
			</xs:sequence>
	</xs:complexType>
	<xs:complexTypeelement name="postProcCbuType"POST_PROC" type="postProcAdcuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Post-processing (prior cryopreservation) data for CBUs<data</xs:documentation>
						</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postProcBaseType"/>
			</xs:complexContent>element>
	</xs:complexType>
					<xs:complexTypeelement name="postProcAdcuTypePOST_THAW" type="postThawAdcuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Post-processing (prior cryopreservation) data for ADCUs<thaw data</xs:documentation>
						</xs:annotation>
					<xs</xs:complexContent>element>
					<xs:extensiongroup baseref="postProcBaseTypenmbrFieldsGroup"/>
				<xs:sequence>
					<xs:element name="CD3PCQA_DATE" type="xs:floatbareDateType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total>Date number of CD3+laboratory cellsquality <assessment</xs:documentation>
						</xs:annotation>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>

In XSD 2.3 and before, collection and post-processing fields use flat structure and use "_FRZN" to distinguish them.

Code Block

language	xml
theme	RDark
firstline	326
title	Version 2.3
linenumbers	true

					<xs:	<xs:element name="VOL" minOccurs="0GRID">
						<xs:annotation>
							<xs:documentation xml:lang="en">Collected>GRID volumeof beforethe processingdonor (withoutof additives) in ml<the ADCU.</xs:documentation>
						</xs:annotation>
						<xs:simpleType>
							<xs:restriction base="xs:shortstring">
								<xs:minInclusivelength value="119"/>
								<xs:maxInclusive value="9999"/>
		</xs:restriction>
						</xs:restriction>simpleType>
						</xs:simpleType>element>
				</xs:sequence>
			</xs:element>extension>
				</xs:complexContent>
	</xs:complexType>
	<xs:elementcomplexType name="VOL_FRZN" minOccurs="0"inventoryType">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total>Type representing volumean frozeninventory (postof processingdonors, ADCUs prior(adult todonor cryopreservation) in ml<unit) and/or CBUs (cord blood units)</xs:documentation>
						</xs:annotation>
						<xs:simpleType>sequence>
							<xs:restrictionelement basename="xs:short">
								<xs:minInclusive value="1"/>
			"DONOR" type="donItemType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:maxInclusivedocumentation valuexml:lang="9999"/>
							en">A donor is an adult person who has consented to donate haematopoietic progenitor cells, that is, HPC(M) or HPC(A) and similar products to an unrelated patient.</xs:restriction>documentation>
						</xs:simpleType>annotation>
					</xs:element>
					<xs:element name="TNCADCU" type="xs:floatadcuItemType" minOccurs="0">
		 maxOccurs="unbounded">
				<xs:annotation>
							<xs:documentation xml:lang="en">Total number of nucleated cells (before processing)>An ADCU (adult donor cryopreserved unit) is a banked, cryopreserved blood product collected from an adult donor.</xs:documentation>
						</xs:annotation>
					</xs:element>

Code Block

language	xml
theme	RDark
title	Version 2.3
linenumbers	true

	<xs:elementcomplexType name="TNC_FRZN" type="xs:float" minOccurs="0">
				inventoryType">
		<xs:annotation>
							<xs:documentation xml:lang="en">Total number>Type representing an inventory of nucleateddonors cells (post processing, prior to cryopreservationand/or cord blood units (CBUs)</xs:documentation>
						</xs:annotation>
		<xs:sequence>
			</xs:element>

Example of ADCU XML

Expand

Code Block

<?xml version="1.0" encoding="UTF-8"?>
<INVENTORIES CREATION_TIME="2022-01-05T21:00:04Z">
	<INVENTORY LISTING_ORGANIZATION="1234" POOL="1234" CONTENT_TYPE="A" UPDATE_MODE="FULL" SNAPSHOT_TIME="2022-02-23T13:00:08Z" SCHEMA_VERSION="2.4">
		<ADCU>
			<BIRTH_DATE>2009-09-02</BIRTH_DATE>
			<SEX>M</SEX>
			<ABO>A</ABO>
			<RHESUS>P</RHESUS>
			<ETHN>AF</ETHN>
			<CCR5>DD</CCR5>
			<HLA>
				<A>
					<SER>
						<FIELD1>1</FIELD1>
						<FIELD2>3</FIELD2>
					</SER>
					<DNA>
						<FIELD1>01:XX</FIELD1>
						<FIELD2>03:XX</FIELD2>
					</DNA>
				</A>
				<B>
					<SER>
						<FIELD1>7</FIELD1>
						<FIELD2>55</FIELD2>
					</SER>
					<DNA>
						<FIELD1>07:XX</FIELD1>
						<FIELD2>55:XX</FIELD2>
					</DNA>
				</B>
				<C>
					<SER>
						<FIELD1>3</FIELD1>
						<FIELD2>7</FIELD2>
					</SER>
					<DNA>
						<FIELD1>03:03</FIELD1>
						<FIELD2>07:XX</FIELD2>
					</DNA>
				</C>
				<E>
					<DNA>
						<FIELD1>04:01</FIELD1>
						<FIELD2>07:02</FIELD2>
					</DNA>
				</E>
				<DRB1>
					<SER>
						<FIELD1>1</FIELD1>
						<FIELD2>15</FIELD2>
					</SER>
					<DNA>
						<FIELD1>01:01</FIELD1>
						<FIELD2>15:XX</FIELD2>
					</DNA>
				</DRB1>
				<DRB3/>
				<DRB4/>
				<DRB5>
					<DNA>
						<FIELD1>01:01</FIELD1>
						<FIELD2/>
					</DNA>
				</DRB5>
				<DQA1/>
				<DQB1>
					<DNA>
						<FIELD1>05:01</FIELD1>
						<FIELD2>06:02</FIELD2>
					</DNA>
				</DQB1>
				<DPA1/>
				<DPB1>
					<DNA>
						<FIELD1>04:02</FIELD1>
						<FIELD2>11:01</FIELD2>
					</DNA>
				</DPB1>
				<MICA>
					<GLS>008:01:01/008:01:02/008:03/008:04+018:01/018:02</GLS>
				</MICA>
				<MICB>
					<GLS>003/005:02:01/005:02:02/005:02:03/005:02:04/005:08/006/010+003/005:02:01/005:02:02/005:02:03/005:02:04/005:08/006/010</GLS>
				</MICB>
			</HLA>
			<KIR>
				<KIR2DL1>NEG</KIR2DL1>
				<KIR2DL2>NEG</KIR2DL2>
				<KIR2DL3>NEG</KIR2DL3>
				<KIR2DL4>POS</KIR2DL4>
				<KIR2DL5A>NEG</KIR2DL5A>
				<KIR2DL5B>NEG</KIR2DL5B>
				<KIR2DS1>POS</KIR2DS1>
				<KIR2DS2>NEG</KIR2DS2>
				<KIR2DS3>NEG</KIR2DS3>
				<KIR2DS4>NEG</KIR2DS4>
				<KIR2DS5>NEG</KIR2DS5>
				<KIR2DP1>NEG</KIR2DP1>
				<KIR3DL1>NEG</KIR3DL1>
				<KIR3DL2>NEG</KIR3DL2>
				<KIR3DL3>NEG</KIR3DL3>
				<KIR3DS1>NEG</KIR3DS1>
				<KIR3DP1>NEG</KIR3DP1>
				<KIR_GLS_URI>https://gl.nmdp.org/nonstrict/multilocus-unphased-genotype/4p</KIR_GLS_URI>
			</KIR>
			<IDM>
				<ANTI_CMV>N</ANTI_CMV>
				<ANTI_CMV_DATE>2009-09-04</ANTI_CMV_DATE>
				<CMV_NAT>N</CMV_NAT>
				<CMV_NAT_DATE>2009-09-04</CMV_NAT_DATE>
				<HBS_AG>N</HBS_AG>
				<ANTI_HBC>N</ANTI_HBC>
				<ANTI_HBS>N</ANTI_HBS>
				<HBV_NAT>N</HBV_NAT>
				<ANTI_HCV>N</ANTI_HCV>
				<HCV_NAT>N</HCV_NAT>
				<ANTI_HEV>N</ANTI_HEV>
				<HEV_NAT>N</HEV_NAT>
				<ANTI_HIV_12>N</ANTI_HIV_12>
				<HIV_1_NAT>N</HIV_1_NAT>
				<HIV_P24>N</HIV_P24>
				<ANTI_HTLV>N</ANTI_HTLV>
				<SYPHILIS>N</SYPHILIS>
				<WNV_NAT>N</WNV_NAT>
				<ANTI_CHAGAS>N</ANTI_CHAGAS>
				<CHAGAS_NAT>N</CHAGAS_NAT>
				<EBV>H</EBV>
				<TOXO>N</TOXO>
				<PB19_NAT>N</PB19_NAT>
				<ALT>1</ALT>
			</IDM>
			<STATUS>AV</STATUS>
			<ID>A999922000001</ID>
			<LOCAL_ID>REG000001</LOCAL_ID>
			<BAG_ID>BAG00BMDW001</BAG_ID>
			<BANK_MANUF_ID WMDA="6789" EMDIS="EN-38"/>
			<BANK_DISTRIB_ID WMDA="6789" EMDIS="EN-38"/>
			<PROC_DATE>2009-09-02</PROC_DATE>
			<PROC_METH>HES</PROC_METH>
			<PROC_METH_TYPE>SPX</PROC_METH_TYPE>
			<FREEZE_DATE>2009-09-02</FREEZE_DATE>
			<FREEZE_METH>C</FREEZE_METH>
			<PROD_MOD>PRR</PROD_MOD>
			<BAG_TYPE>80/20</BAG_TYPE>
			<BAGS>1</BAGS>
			<BACT_CULT>N</BACT_CULT>
			<FUNG_CULT>N</FUNG_CULT>
			<HEMO_STATUS>DN</HEMO_STATUS>
			<ATT_SEG>2</ATT_SEG>
			<DNA_SMPL>true</DNA_SMPL>
			<OTH_SMPL>true</OTH_SMPL>
			<CT_COMPLETE_DATE>2016-09-22</CT_COMPLETE_DATE>
			<CT_SMPL_TYPE>ED</CT_SMPL_TYPE>
			<AL_RED_BC>3</AL_RED_BC>
			<AL_SER>4</AL_SER>
			<SER_QUANT>10.0</SER_QUANT>
			<AL_PLA>2</AL_PLA>
			<PLA_QUANT>10.0</PLA_QUANT>
			<RELEASE_READY>true</RELEASE_READY>
			<COLL_DATE>2009-09-02</COLL_DATE>
			<COLL_TYPE>P</COLL_TYPE>
			<POST_COLL>
				<VOL>100</VOL>
				<TNC>1.20E9</TNC>
				<CD34PC>1.50E6</CD34PC>
				<CD3PC>30.5E6</CD3PC>
			</POST_COLL>
			<POST_PROC>
				<VOL>25</VOL>
				<CFU>1.23E6</CFU>
				<MNC>552999973</MNC>
				<TNC>9.90E8</TNC>
				<VIABILITY_TNC>
					<VALUE>95</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_TNC>							
				<CD34PC>1.10E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>92</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<RED_BC>9.00E7</RED_BC>
				<CD3PC>15.5E6</CD3PC>
			</POST_PROC>
			<POST_THAW>
				<CFU>2.1E5</CFU>
				<CFU_GROWTH>true</CFU_GROWTH>
				<CFU_METHOD>GM</CFU_METHOD>
				<TNC>250E7</TNC>
				<CD34PC>2.1E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>91</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<LAST_TEST_DATE>2009-09-02</LAST_TEST_DATE>
			</POST_THAW>
			<NMBR_TRANS>1</NMBR_TRANS>
			<NMBR_PREG>1</NMBR_PREG>
			<NMBR_MARR>0</NMBR_MARR>
			<NMBR_PBSC>0</NMBR_PBSC>
			<QA_DATE>2009-09-02</QA_DATE>
			<GRID>99991234567ABCDEF35</GRID>
		</ADCU>
	</INVENTORY>
</INVENTORIES>

Timeline

...

Proposal ready:

31 Aug 2021

...

XSD Approval

22 Feb 2022

XSD public review

01 Mar 2022 - 04 Apr 2022

<xs:element name="DONOR" type="donItemType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:documentation xml:lang="en">A donor is an adult person who has consented to donate haematopoietic progenitor cells, that is, HPC(M) or HPC(A) and similar products to an unrelated patient.</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CBU" type="cbuItemType" minOccurs="0" maxOccurs="unbounded">
				<xs:annotation>
					<xs:documentation xml:lang="en">A cord blood unit (CBU) is a banked, frozen blood product extracted from a newborn baby's umbilical cord.</xs:documentation>
				</xs:annotation>
			</xs:element>
		</xs:sequence>

(Impact XML format) Improve some flat structure to nested structure

Improved to use nested structure of POST_COLL (post collection), introduced item type postCollCbuType, postCollAdcuType, postCollBaseType
Improved to use nested structure of POST_PROC (post processing/pre-cryopreservation), introduced item type postProcCbuType, postProcAdcuType, postProcBaseType
Added POST_THAW object. See details in the part for RFC 009 below

Code Block

language	xml
theme	RDark
firstline	603
title	Version 2.4 Inventories.xsd
linenumbers	true

					<xs:element name="POST_COLL" type="postCollCbuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Post collection (prior processing) data</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POST_PROC" type="postProcCbuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Data of post-processing (prior cryopreservation)</xs:documentation>
						</xs:annotation>
					</xs:element>

Code Block

language	xml
theme	RDark
firstline	719
title	Version 2.4 Inventories.xsd
linenumbers	true

					<xs:element name="POST_COLL" type="postCollAdcuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Post collection (prior processing) data</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="POST_PROC" type="postProcAdcuType" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Post-processing (prior cryopreservation) data</xs:documentation>
						</xs:annotation>
					</xs:element>

Code Block

language	xml
theme	RDark
firstline	1157
title	Version 2.4 basicTypes.xsd
linenumbers	true

<xs:complexType name="postCollBaseType">
		<xs:annotation>
			<xs:documentation>Post-collection (prior processing) base data</xs:documentation>
		</xs:annotation>
		<xs:sequence>
			<xs:element name="VOL" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Collected volume (without additives) in ml</xs:documentation>
				</xs:annotation>
				<xs:simpleType>
					<xs:restriction base="xs:float">
						<xs:minInclusive value="1.0"/>
						<xs:maxInclusive value="9999.9"/>
					</xs:restriction>
				</xs:simpleType>
			</xs:element>
			<xs:element name="TNC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of nucleated cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CD34PC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of CD34+ cells</xs:documentation>
				</xs:annotation>
			</xs:element>
		</xs:sequence>
	</xs:complexType>
	<xs:complexType name="postCollCbuType">
		<xs:annotation>
			<xs:documentation>Post-collection (prior processing) data for CBUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postCollBaseType"/>
		</xs:complexContent>
	</xs:complexType>
	<xs:complexType name="postCollAdcuType">
		<xs:annotation>
			<xs:documentation>Post-collection (prior processing) data for ADCUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postCollBaseType">
				<xs:sequence>
					<xs:element name="CD3PC" type="xs:float" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of CD3+ cells </xs:documentation>
						</xs:annotation>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>

Code Block

language	xml
theme	RDark
firstline	1209
title	Version 2.4 basicTypes.xsd
linenumbers	true

<xs:complexType name="postProcBaseType">
		<xs:annotation>
			<xs:documentation>Post-processing (prior cryopreservation) base data</xs:documentation>
		</xs:annotation>
		<xs:sequence>
			<xs:element name="VOL" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total volume in ml</xs:documentation>
				</xs:annotation>
				<xs:simpleType>
					<xs:restriction base="xs:float">
						<xs:minInclusive value="1.0"/>
						<xs:maxInclusive value="9999.9"/>
					</xs:restriction>
				</xs:simpleType>
			</xs:element>
			<xs:element name="CFU" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total count of colony forming units</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="MNC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total Number of mononucleated cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="TNC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of nucleated cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="VIABILITY_TNC" type="viabilityType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding TNC</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CD34PC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of CD34+ cells </xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="VIABILITY_CD34PC" type="viabilityType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding CD43+ cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="VIABILITY_CD45PC" type="viabilityType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding CD45+ cells</xs:documentation>
				</xs:annotation>
			</xs:element>
		</xs:sequence>
	</xs:complexType>
	<xs:complexType name="postProcCbuType">
		<xs:annotation>
			<xs:documentation>Post-processing (prior cryopreservation) data for CBUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postProcBaseType">
                <xs:sequence>
					<xs:element name="NRBC" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of nucleated red blood cells </xs:documentation>
						</xs:annotation>
						<xs:simpleType>
							<xs:restriction base="xs:float">
								<xs:minInclusive value="0.0E0"/>
								<xs:maxInclusive value="999.9E7"/>
							</xs:restriction>
						</xs:simpleType>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>
	<xs:complexType name="postProcAdcuType">
		<xs:annotation>
			<xs:documentation>Post-processing (prior cryopreservation) data for ADCUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postProcBaseType">
				<xs:sequence>
                    <xs:element name="RBC" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of red blood cells </xs:documentation>
						</xs:annotation>
						<xs:simpleType>
							<xs:restriction base="xs:float">
								<xs:minInclusive value="0.0E0"/>
								<xs:maxInclusive value="99.9E9"/>
							</xs:restriction>
						</xs:simpleType>
					</xs:element>
					<xs:element name="CD3PC" type="xs:float" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of CD3+ cells </xs:documentation>
						</xs:annotation>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>

In XSD 2.3 and before, collection and post-processing fields use flat structure and use "_FRZN" to distinguish them.

Code Block

language	xml
theme	RDark
firstline	326
title	Version 2.3
linenumbers	true

					<xs:element name="VOL" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Collected volume before processing (without additives) in ml</xs:documentation>
						</xs:annotation>
						<xs:simpleType>
							<xs:restriction base="xs:short">
								<xs:minInclusive value="1"/>
								<xs:maxInclusive value="9999"/>
							</xs:restriction>
						</xs:simpleType>
					</xs:element>
					<xs:element name="VOL_FRZN" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total volume frozen (post processing, prior to cryopreservation) in ml</xs:documentation>
						</xs:annotation>
						<xs:simpleType>
							<xs:restriction base="xs:short">
								<xs:minInclusive value="1"/>
								<xs:maxInclusive value="9999"/>
							</xs:restriction>
						</xs:simpleType>
					</xs:element>
					<xs:element name="TNC" type="xs:float" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of nucleated cells (before processing)</xs:documentation>
						</xs:annotation>
					</xs:element>
					<xs:element name="TNC_FRZN" type="xs:float" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Total number of nucleated cells (post processing, prior to cryopreservation)</xs:documentation>
						</xs:annotation>
					</xs:element>

Example of ADCU XML

Expand

Code Block

linenumbers	true

<?xml version="1.0" encoding="UTF-8"?>
<INVENTORIES CREATION_TIME="2022-01-05T21:00:04Z">
	<INVENTORY LISTING_ORGANIZATION="1234" POOL="1234" CONTENT_TYPE="A" UPDATE_MODE="FULL" SNAPSHOT_TIME="2022-02-23T13:00:08Z" SCHEMA_VERSION="2.4">
		<ADCU>
			<BIRTH_DATE>2009-09-02</BIRTH_DATE>
			<SEX>M</SEX>
			<ABO>A</ABO>
			<RHESUS>P</RHESUS>
			<ETHN>AF</ETHN>
			<CCR5>DD</CCR5>
			<HLA>
				<A>
					<SER>
						<FIELD1>1</FIELD1>
						<FIELD2>3</FIELD2>
					</SER>
					<DNA>
						<FIELD1>01:XX</FIELD1>
						<FIELD2>03:XX</FIELD2>
					</DNA>
				</A>
				<B>
					<SER>
						<FIELD1>7</FIELD1>
						<FIELD2>55</FIELD2>
					</SER>
					<DNA>
						<FIELD1>07:XX</FIELD1>
						<FIELD2>55:XX</FIELD2>
					</DNA>
				</B>
				<C>
					<SER>
						<FIELD1>3</FIELD1>
						<FIELD2>7</FIELD2>
					</SER>
					<DNA>
						<FIELD1>03:03</FIELD1>
						<FIELD2>07:XX</FIELD2>
					</DNA>
				</C>
				<E>
					<DNA>
						<FIELD1>04:01</FIELD1>
						<FIELD2>07:02</FIELD2>
					</DNA>
				</E>
				<DRB1>
					<SER>
						<FIELD1>1</FIELD1>
						<FIELD2>15</FIELD2>
					</SER>
					<DNA>
						<FIELD1>01:01</FIELD1>
						<FIELD2>15:XX</FIELD2>
					</DNA>
				</DRB1>
				<DRB3/>
				<DRB4/>
				<DRB5>
					<DNA>
						<FIELD1>01:01</FIELD1>
						<FIELD2/>
					</DNA>
				</DRB5>
				<DQA1/>
				<DQB1>
					<DNA>
						<FIELD1>05:01</FIELD1>
						<FIELD2>06:02</FIELD2>
					</DNA>
				</DQB1>
				<DPA1/>
				<DPB1>
					<DNA>
						<FIELD1>04:02</FIELD1>
						<FIELD2>11:01</FIELD2>
					</DNA>
				</DPB1>
				<MICA>
					<GLS>008:01:01/008:01:02/008:03/008:04+018:01/018:02</GLS>
				</MICA>
				<MICB>
					<GLS>003/005:02:01/005:02:02/005:02:03/005:02:04/005:08/006/010+003/005:02:01/005:02:02/005:02:03/005:02:04/005:08/006/010</GLS>
				</MICB>
			</HLA>
			<KIR>
				<KIR2DL1>NEG</KIR2DL1>
				<KIR2DL2>NEG</KIR2DL2>
				<KIR2DL3>NEG</KIR2DL3>
				<KIR2DL4>POS</KIR2DL4>
				<KIR2DL5A>NEG</KIR2DL5A>
				<KIR2DL5B>NEG</KIR2DL5B>
				<KIR2DS1>POS</KIR2DS1>
				<KIR2DS2>NEG</KIR2DS2>
				<KIR2DS3>NEG</KIR2DS3>
				<KIR2DS4>NEG</KIR2DS4>
				<KIR2DS5>NEG</KIR2DS5>
				<KIR2DP1>NEG</KIR2DP1>
				<KIR3DL1>NEG</KIR3DL1>
				<KIR3DL2>NEG</KIR3DL2>
				<KIR3DL3>NEG</KIR3DL3>
				<KIR3DS1>NEG</KIR3DS1>
				<KIR3DP1>NEG</KIR3DP1>
				<KIR_GLS_URI>https://gl.nmdp.org/nonstrict/multilocus-unphased-genotype/4p</KIR_GLS_URI>
			</KIR>
			<IDM>
				<ANTI_CMV>N</ANTI_CMV>
				<ANTI_CMV_DATE>2009-09-04</ANTI_CMV_DATE>
				<CMV_NAT>N</CMV_NAT>
				<CMV_NAT_DATE>2009-09-04</CMV_NAT_DATE>
				<HBS_AG>N</HBS_AG>
				<ANTI_HBC>N</ANTI_HBC>
				<ANTI_HBS>N</ANTI_HBS>
				<HBV_NAT>N</HBV_NAT>
				<ANTI_HCV>N</ANTI_HCV>
				<HCV_NAT>N</HCV_NAT>
				<ANTI_HEV>N</ANTI_HEV>
				<HEV_NAT>N</HEV_NAT>
				<ANTI_HIV_12>N</ANTI_HIV_12>
				<HIV_1_NAT>N</HIV_1_NAT>
				<HIV_P24>N</HIV_P24>
				<ANTI_HTLV>N</ANTI_HTLV>
				<SYPHILIS>N</SYPHILIS>
				<WNV_NAT>N</WNV_NAT>
				<ANTI_CHAGAS>N</ANTI_CHAGAS>
				<CHAGAS_NAT>N</CHAGAS_NAT>
				<EBV>H</EBV>
				<TOXO>N</TOXO>
				<PB19_NAT>N</PB19_NAT>
				<ALT>1</ALT>
			</IDM>
			<STATUS>AV</STATUS>
			<ID>A999922000001</ID>
			<LOCAL_ID>REG000001</LOCAL_ID>
			<BAG_ID>BAG00BMDW001</BAG_ID>
			<BANK_MANUF_ID WMDA="6789" EMDIS="EN-38"/>
			<BANK_DISTRIB_ID WMDA="6789" EMDIS="EN-38"/>
			<PROC_DATE>2009-09-02</PROC_DATE>
			<PROC_METH>HES</PROC_METH>
			<PROC_METH_TYPE>SPX</PROC_METH_TYPE>
			<FREEZE_DATE>2009-09-02</FREEZE_DATE>
			<FREEZE_METH>C</FREEZE_METH>
			<PROD_MOD>PRR</PROD_MOD>
			<BAG_TYPE>80/20</BAG_TYPE>
			<BAGS>1</BAGS>
			<BACT_CULT>N</BACT_CULT>
			<FUNG_CULT>N</FUNG_CULT>
			<HEMO_STATUS>DN</HEMO_STATUS>
			<ATT_SEG>2</ATT_SEG>
			<DNA_SMPL>true</DNA_SMPL>
			<OTH_SMPL>true</OTH_SMPL>
			<CT_COMPLETE_DATE>2016-09-22</CT_COMPLETE_DATE>
			<CT_SMPL_TYPE>ED</CT_SMPL_TYPE>
			<AL_RED_BC>3</AL_RED_BC>
			<AL_SER>4</AL_SER>
			<SER_QUANT>10.0</SER_QUANT>
			<AL_PLA>2</AL_PLA>
			<PLA_QUANT>10.0</PLA_QUANT>
			<RELEASE_READY>true</RELEASE_READY>
			<COLL_DATE>2009-09-02</COLL_DATE>
			<COLL_TYPE>P</COLL_TYPE>
			<POST_COLL>
				<VOL>100</VOL>
				<TNC>1.20E9</TNC>
				<CD34PC>1.50E6</CD34PC>
				<CD3PC>30.5E6</CD3PC>
			</POST_COLL>
			<POST_PROC>
				<VOL>25</VOL>
				<CFU>1.23E6</CFU>
				<MNC>552999973</MNC>
				<TNC>9.90E8</TNC>
				<VIABILITY_TNC>
					<VALUE>95</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_TNC>							
				<CD34PC>1.10E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>92</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<RED_BC>9.00E7</RED_BC>
				<CD3PC>15.5E6</CD3PC>
			</POST_PROC>
			<POST_THAW>
				<CFU>2.1E5</CFU>
				<CFU_GROWTH>true</CFU_GROWTH>
				<CFU_METHOD>GM</CFU_METHOD>
				<TNC>250E7</TNC>
				<CD34PC>2.1E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>91</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<LAST_TEST_DATE>2009-09-02</LAST_TEST_DATE>
			</POST_THAW>
			<NMBR_TRANS>1</NMBR_TRANS>
			<NMBR_PREG>1</NMBR_PREG>
			<NMBR_MARR>0</NMBR_MARR>
			<NMBR_PBSC>0</NMBR_PBSC>
			<QA_DATE>2009-09-02</QA_DATE>
			<GRID>99991234567ABCDEF35</GRID>
		</ADCU>
	</INVENTORY>
</INVENTORIES>

...

Implementation / testing

TBD

...

Release Date

TBD

...

Progress Bar | Vectors (Formerly: SP Progress bar)

current-step	3
steps	Preparation, Draft, Discussion, Public review , Implementation, Release

Table of Contents

Introduction

XSD 2.4 includes changes for RFCs as below:

RFC-007: more fields to distinguish IDM-tests (HBV, HCV, HEV, West Nile Virus and Chagas)

RFC-008: Introduction of Adult Adult Donor Cryopreserved Unit (ADCU)

RFC-009 R2sh-CBU fields request

RFC-010 CBU Viability for Multiple Cell Types

Any question or comments are welcome. You can ask question regarding XSD 2.4 here : https://share.wmda.info/questions/topics/403341316/xsdv24 or send email to support@wmda.info.

For members who have account in share and are interested to check the detail of the discussion of the changes, you can check the internal meeting notes for XSD 2.4 in the link: https://share.wmda.info/x/agztFQ.

Download XSD schema version 2.4

Info
Please notice that XSD 2.3 rule GRID/ID must be implemented as well if upgrade to XSD 2.4 directly from XSD 2.2

Attachments

Changes between version 2.4 and 2.3

Updated version number to 2.4

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<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" elementFormDefault="qualified" attributeFormDefault="unqualified" version="2.4">

Update version number to 2.3

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<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" elementFormDefault="qualified" attributeFormDefault="unqualified" version="2.3">

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RFC 007 IDM changes

XSD schema doc changes

Add new fields ANTI_HEV, HEV_NAT, CHAGAS_NAT
Rename fields WMV to WNV_NAT, CHAGAS to ANTI_CHAGAS
Update order of fields HCV_NAT and HBV_NAT

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			<xs:element name="ANTI_HBS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis B status (antibody to hepatitis B surface antigen)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HBV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HBV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HCV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis C status (antibody to hepatitis C virus)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HCV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HCV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HEV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis E status (antibody to hepatitis E virus)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HEV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HEV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HIV_12" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Anti-HIV 1/2 status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HIV_1_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HIV-1 NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HIV_P24" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HIV p24 status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HTLV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Antibody to HTLV I/II</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="SYPHILIS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Syphilis status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="WNV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">WNV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_CHAGAS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Chagas antibody status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CHAGAS_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Chagas NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="EBV" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">EBV status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="TOXO" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Toxoplasmosis status</xs:documentation>
				</xs:annotation>
			</xs:element>

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			<xs:element name="ANTI_HBS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis B status (antibody to hepatitis B surface antigen)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HCV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Hepatitis C status (antibody to hepatitis C virus)</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HIV_12" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Anti-HIV 1/2 status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HIV_1_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HIV-1 NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HIV_P24" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HIV p24 status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HCV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HCV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="ANTI_HTLV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Antibody to HTLV I/II</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="SYPHILIS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Syphilis status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="WNV" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">WNV status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CHAGAS" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Chagas status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="EBV" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">EBV status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="TOXO" type="idmValueExtType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Toxoplasmosis status</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="HBV_NAT" type="idmValueType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">HBV NAT status</xs:documentation>
				</xs:annotation>
			</xs:element>

Example of IDM XML

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RFC 009 Add Ready-to-Ship structrue

XSD schema changes

(Impact XML format) Add POST_THAW

object and item

items

Following items are added: postThawBaseType, postThawCbuType, postThawAdcuType

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	<xs:complexType name="postThawBaseType">
		<xs:annotation>
			<xs:documentation>Post-thaw base data</xs:documentation>
		</xs:annotation>
		<xs:sequence>
			<xs:element name="CFU" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total count of colony forming units</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CFU_GROWTH" type="xs:boolean" minOccurs="0">
				<xs:annotation>
					<xs:documentation>CFU growth or not</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CFU_METHOD" type="cfuMethodType" minOccurs="0">
				<xs:annotation>
					<xs:documentation>CFU count method</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="CD34PC" type="xs:float" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Total number of CD34+ cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="VIABILITY_CD34PC" type="viabilityType" minOccurs="0">
				<xs:annotation>
					<xs:documentation xml:lang="en">Viability information regarding CD43+ cells</xs:documentation>
				</xs:annotation>
			</xs:element>
			<xs:element name="LAST_TEST_DATE" type="xs:date" minOccurs="0">
				<xs:annotation>
					<xs:documentation>last test date</xs:documentation>
				</xs:annotation>
			</xs:element>
		</xs:sequence>

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		<xs:complexType name="postThawCbuType">
		<xs:annotation>
			<xs:documentation>Post-thaw data for CBUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postThawBaseType">
				<xs:sequence>
					<xs:element name="VIABILITY_TNC" type="viabilityType" minOccurs="0">
						<xs:annotation>
							<xs:documentation xml:lang="en">Viability information regarding TNC</xs:documentation>
						</xs:annotation>
					</xs:element>
				</xs:sequence>
			</xs:extension>
		</xs:complexContent>
	</xs:complexType>
	<xs:complexType name="postThawAdcuType">
		<xs:annotation>
			<xs:documentation>Post-thaw data for ADCUs</xs:documentation>
		</xs:annotation>
		<xs:complexContent>
			<xs:extension base="postThawBaseType"/>
		</xs:complexContent>
	</xs:complexType>

(Impact XML format)Add RELEASE_READY field

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					<xs:element name="RELEASE_READY" type="xs:boolean" minOccurs="0">
						<xs:annotation>
							<xs:documentation>Identify whether unit is ready for release by the stem cell bank</xs:documentation>
						</xs:annotation>
					</xs:element>

(Impact XML )Add item cfuMethodType

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	<xs:simpleType name="cfuMethodType">
		<xs:annotation>
			<xs:documentation>Method used for CFU counting</xs:documentation>
		</xs:annotation>
		<xs:restriction base="xs:string">
			<xs:enumeration value="TT"/>
			<xs:enumeration value="GM"/>
			<xs:enumeration value="OT"/>
		</xs:restriction>
	</xs:simpleType>

Example of CBU XML for RFC-009

Add POST_THAW, RELEASE_READY, POST_COLL,POST_PROC. The example of viability usage from RFC-010 also included to make the example more complete

Code Block

language	xml
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            ...
            <PLA_QUANT>10.0</PLA_QUANT>
			<POST_THAW>
				<CFU>2.1E5</CFU>
				<CFU_GROWTH>true</CFU_GROWTH>
				<CFU_METHOD>GM</CFU_METHOD>
				<TNC>250E7</TNC>
				<VIABILITY_TNC>
					<VALUE>95</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2010-09-02</DATE>
				</VIABILITY_TNC>
				<CD34PC>2.1E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>91</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<LAST_TEST_DATE>2009-09-02</LAST_TEST_DATE>
			</POST_THAW>
			<RELEASE_READY>true</RELEASE_READY>
			<ID>WMDA0CBU001</ID>
			<COLL_DATE>2009-09-02</COLL_DATE>
			<POST_COLL>
				<VOL>100</VOL>
				<TNC>1.20E9</TNC>
				<CD34PC>1.50E6</CD34PC>
			</POST_COLL>
			<POST_PROC>
				<VOL>25</VOL>
				<CFU>1.23E6</CFU>
				<MNC>552999973</MNC>
				<TNC>9.90E8</TNC>
				<VIABILITY_TNC>
					<VALUE>95</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_TNC>							
				<CD34PC>1.10E6</CD34PC>
				<VIABILITY_CD34PC>
					<VALUE>92</VALUE>
					<METHOD>7A</METHOD>
					<DATE>2009-09-02</DATE>
				</VIABILITY_CD34PC>
				<RED_BC>9.00E7</RED_BC>					
			</POST_PROC>
			<MAT> 
             ...                        </MAT>

...

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Old Version 13

New Version 39

Key

Introduction

Download XSD schema version 2.4

Changes between version 2.4 and 2.3

Updated version number to 2.4

RFC 007 IDM changes

XSD schema doc changes

RFC 008 Add whole ADCU structure

XSD schema changes

Change the documentation

Add new item type unitItemBaseType

Add adcuItemType

(Impact XML format) Improve some flat structure to nested structure

Example of IDM XML

RFC 008 Add whole ADCU structure

XSD schema changes

Change the documentation

Add new item type unitItemBaseType

Add adcuItemType

Example of ADCU XML

(Impact XML format) Improve some flat structure to nested structure

Example of ADCU XML

Introduction

Download XSD schema version 2.4

Changes between version 2.4 and 2.3

Updated version number to 2.4

RFC 007 IDM changes

XSD schema doc changes

Example of IDM XML

RFC 009 Add Ready-to-Ship structrue

XSD schema changes

(Impact XML format) Add POST_THAW

items

(Impact XML format)Add RELEASE_READY field

(Impact XML )Add item cfuMethodType

Example of CBU XML for RFC-009