Page History

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5-locus Haplofrequency estimation was performed on all organisations/populations with at least 10000 donors in HLA-A, -B, -C, -DRB1 and -DQB1 types where ambiguity was low enough to be useful. Organisations in the same country/within the same population are usually combined, e.g. AT-ABMDR (Austrian ION-2614, Austrian Bone Marrow Donors) and ATand AT-Verein GFL (AustriaION- Verein geben fur Lebel4961, Verein Geben für Leben) but *not* for US-NMDP (general US population) and US-GOL (predominantly Ashkenazi Jews). 

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Below, you can find a figure how the haplotype frequency (HF) sets are assigned to the donors and cord blood units. The system first determines if both COUNTRY registry ION and ETHNICITY ethnicity are provided. Registry ION is then used to look up the country/ region that it belongs to. If yes, then it will check if an ethnicity specific set for this country registry exists. If the donor for example is coming from USA and has ethnicity HISA, then we do not have a specific set available. However, there is a more broad Hispanic HF set available (USA-HI) and this will then be used.

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South America (sam): AR, BR, UY (Set number: 34)

Since WMDA is doing these calculations on behalf of organisations, it is important for organisations to submit high resolution typing when available and donor ethnicity data. This greatly improves the haplofrequency sets generated and allows for individual donor match grades to be more accurate. 

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