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Since WMDA is doing these calculations on behalf of organisations, it is important for organisations to submit high resolution typing when available and donor ethnicity data. This greatly improves the haplofrequency sets generated and allows for individual donor match grades to be more accurate. 

NOTE: None of the Japanese donors have been typed for DQB1 this means that no Japanese donors were included in the calculations. This means that the haplotype frequency set applied to Japanese donors are probably biased against Japanese haplotype frequencies. We have kindly received a self-generated haplotype frequency set from the Japanese registry and are working on integrating it in the Hap-E algorithm that is part of Search and Match. 

NOTE: in some cases a countries donors may be used in a national haplotype frequency set as well as a regional one. For example Austrian donors are used in their own set (#2) as well as the Eastern Europe region set (#33). When calculating match probabilities always the most specific set is used. So for donors from IONs 2614 or 4961 set #2 is used, but for Romanian donors there were not enough high resolution donors for their own set so the regional set is used (#33). 

It is important to know that your organisations frequency set is changeable!

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