Condition
Endometriosis is a condition that is caused by endometrium growing outside the uterus. Mostly in ovaries, the Fallopian tubes and tissue surrounding the uterus. Most common and directly related symptoms are pain (which can vary in intensity, site, triggers, timing and duration). Anemia is associated with endometriosis due to menorrhagia. Based on retrospective studies there seems to be an increased risk for the development of ovarian cancer, but preventative measures are not advised.
Guidance at RECRUITMENT
Accept, if pain well controlled with acceptable medication and not anemic.
Guidance at CT/WORK-UP
Accept, if pain well controlled with acceptable medication and not anemic.
Individual at Risk
Potentially donor
Justification for guidance
Because G-CSF can be used for thin endometrium associated with infertility (usually infused directly into the uterine cavity) a role of G-CSF in exacerbation or triggering endometriosis can be suspected. However, because the site of administration in PBSC donation is different and there are no published warnings about G-CSF in endometriosis at this moment uncomplicated endometriosis is not considered a contra-indication for both forms of donation.
References
Donor suitability working group WMDA meeting Munich 2018.
Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. Endometriosis. Nat Rev Dis Primers. 2018 Jul 19;4(1):9. doi: 10.1038/s41572-018-0008-5.
Eftekhar M, Naghshineh E, Khani P. J Role of granulocyte colony-stimulating factor in human reproduction. Res Med Sci. 2018 Jan 29;23:7. doi: 10.4103/jrms.JRMS_628_17. eCollection 2018.
Heidemann LN, Hartwell D, Heidemann CH, Jochumsen KM. The relation between endometriosis and ovarian cancer - a review. Acta Obstet Gynecol Scand. 2014 Jan;93(1):20-31. doi: 10.1111/aogs.12255. Epub 2013 Oct 9.