Individual at risk
Donor / Recipient
Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation)
Unacceptable if current or recent history of alcohol use disorder.
Unacceptable if history of alcoholic liver disease or cardiomyopathy.
Registries may wish to set an upper limit of safe alcohol consumption based on local recommendations.
Guidance at CT/WORK-UP
Unacceptable if current or recent history of alcohol use disorder.
Unacceptable if history of alcoholic liver disease or cardiomyopathy.
Registries may wish to set an upper limit of safe alcohol consumption based on local recommendations.
At the CT stage, registries may wish to request liver function tests in donors with a history of current or past alcohol use disorder.
Justification/References
Alcoholics or those with a heavy alcohol intake may be less reliable donors and there is a risk of donor attrition or withdrawal at a late stage. In addition, there is a possible risk of donation in those with alcohol-related organ damage, such as cirrhosis or cardiomyopathy.
G-CSF has been documented to cause transient rises in liver function tests, so should be used with caution in those with a history of liver disease related to alcohol.