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titleDoes De-activating a patient record delete it from the system?

No. De-activating a patient will just remove it from the OptiMatch Hap-E Search and ATLAS server and the 'Active patients' list and place it in the 'Inactive patients' list.

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titleCan I switch off the Predictive Search and run it just like the old system?
 You can switch to use allele frequencies instead of haplotype frequencies, which is the matching approach/method that the old system used. However, all matching algorithms vary slightly so the new search powered by OptiMatch Hap-E Search and/or ATLAS may not match results from the old system, even with allele frequencies in use.

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titleIt seems like the search results are automatically ordered on age for adults and TNC for cords. Is that correct?

The default sorting criteria from OptiMatch Hap-E Search and ATLAS for donors are: 

1. HLA

2. probability in 10% intervals

3. donor age in 5 year intervals for adults


The default sorting criteria from OptiMatch Hap-E Search and ATLAS for cords are: 

1. HLA (6/6, 5/6, 4/6 categories)

2. Number of total nucleated cells (TNC) for cords within HLA match category

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titleWhat sequence do donors appear in on the reports? Are any types of donors given precedence?

The default sorting criteria from OptiMatch Hap-E Search and ATLAS are:

1. HLA

2. probability in 10% intervals

3. donor age in 5 year intervals

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titleWhy is a male donor listed after a female donor of the same age and HLA? Why is a donor with an identical CMV status listed after one with a missing or different CMV status?

OptiMatch Hap-E Search and ATLAS does not consider binary attributes like gender or CMV for  sorting at all. If you see a rich donor list and prefer, for example,  male donors you should use the filtering capability of OptiMatchthe algorithms.

Rationale: There is no agreed concept for weighing secondary match  criteria like age, gender or CMV against each other. The approach to sort by probability in blocks and then by age plus ad hoc filtering gives the user maximum control of the appearance of the list.

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titleWhy is a matching donor who is typed at higher resolution listed after donors typed at lower resolution?

This can happen only if the difference in resolution is not  considered sufficiently relevant in the given context by OptiMatchHap-E Search and ATLAS. Below are some possible (not mutually exclusive) reasons:

  1. The allele designations encode for the identical ARD (antigen  recognition domain) and OptiMatch Hap-E Search and ATLAS only matches for the ARD part of the HLA protein complex. For example B*07:ANVB stands for B*07:02/07:61 which both encode for the same ARD (here: exon 2 and 3). Hence OptiMatch Hap-E Search and ATLAS is regarding the codes B*07:02, B*07:61 and B*07:ANVB all as allele matches for each other but might give different matching probabilities for phenotypes containing each of those three codes since haplotypes  involving B*07:02 and B*07:61 are having individual frequencies.
  2. The resolution only looks higher but, in fact, is lower (e.g.  B*15:12 currently is only a single allele while B*15:12:01G covers three), identical (e.g. A*80:01, A*80:01:01 and A*80:01:01G cover exactly the same alleles) or not directly comparable since each code is containing some alleles not covered by the other (e.g. comparing  B*07:TDVB and B*07:02:01G the former also covers a lot more variants of  B*07:02 like  B*07:02:02 to B*07:02:05 while it is excluding other alleles like B*07:44 and B*07:49N).
  3. The broader code only contains additional alleles which have never  been observed in the population whose haplotype frequencies are used - at least not in a relevant haplotypical context. Their frequency could  also be so low that it is disregarded due to rounding or the 10%  probability grouping explained elsewhere. This applies, in particular,  to all null variants of expressed alleles with identical first two field  designations.

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