...
- Filter for returning only donors/CBU with typing at C (and/or DQB1).
- Filter on match class so you can go directly to the 5/8 or 4/8 potential matches. Scheduled for delivery December 2022
- Match probability calculation for 3 and 4 mismatches. Scheduled for delivery Q1 of 2023.
- "scoreScore" based sorting for 3 and 4 mismatch results. Scheduled for delivery to production early December 2022. This method is explained below:
...
- Assign a score based on the typed loci and their resolution
- Each locus can have one of the following “resolutions”
- High resolution typing (only one ARD)
- Low or intermediate typing
- No typing
- Each resolution class per locus has a “score”.
- High = 20
- Low or intermediate = 17
- No typing = 0
- We sort CBUs based on the sum of the score first and only then by TNC/CD34
- n/6: sum of score at A, B, DRB1 (also at C?)
- n/8: sum of score at A, B, C, DRB1
- n/10: sum of score at A, B, C, DRB1 and DQB1
- Sorting for 0 , 1 and 2 mismatches remains unchanged
Because of the way the scores are assigned per locus, a CBU with typing at C when doing an n/8 search will always be ranked higher than a CBU with high resolution typing at 3 loci and no typing at C.
Below you can find some examples.
Match probabilities
Calculation of actual match probabilities would provide a better way of ranking than score-based ranking. Unfortunately this requires quite a lot of work in core elements of the Hap-E algorithm. This therefore needs to be done with great care and needs to be thoroughly tested in order to make sure no part of the Hap-E algorithm is accidentally broken as a result of the added functionality. It therefore cannot be delivered until Q1 of 2023.