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The match list presents all possible options. In order to help search coordinators to select the best potential stem cell source, WMDA has is implemented an additional tool features to assist search coordinators, you can read the details below.
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- Step 1: run a two mismatch cord blood search, before you can start a 3 three mismatch search
- Step 2: run a three mismatch cord blood search before you can start a four mismatch cord blood search
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Three and/or four mismatch cord blood search results do not have any match probabilities calculated, the results are currently sorted within their match class (e.g. 5/8, 4/8) only by TNC or CD34+. The Hap-E algorithm in the Search & Match Service returns more potential cord blood units than the legacy system. Many of these “extra” cord blood units tend to be low probability cord blood options, because these cord blood units have low HLA resolution typing or missing allele typing.
This means that a poorly matched cord blood units with high cell dose are at the top of the match list and potentially better cord blood units with a high enough cell dose are lower. This means that in our new Search & Match Service For a search coordinator, it is harder to idenity identify the best possible cord blood, because of the increased number of valid potential matches.
In an effort to improve the search coordinator's experience when performing 3 three and 4 /or four mismatch searches we are cord blood searches, WMDA is currently developing several features that should improve the efficiency of finding suitable CBUs. These are:
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