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Hap-E search

ATLAS search

All probabilities are rounded to integer values.

→ 0%:

  • Values 0 < p < 0.5
  • No shared genotype between donor and patient.

All probabilities are rounded to integer values.

→ 0%:

  • Values 0 < p < 0.5
  • No shared genotype between donor and patient.


8.1 Locus match probabilities

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: Definition

Hap-E search

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ATLAS search

match, i.e. 10/10, 8/8 or 6/6

  • The locus match probability is the relative probability that this locus is a match in the 1 mismatch case.

mismatch, i.e. 9/10, 7/8 or 5/6

  • The locus match probability is the relative probability that this locus is a match in the 2 mismatch case.

So this probability provides information on which locus the next mismatch will occur.

match, i.e. 10/10, 8/8 or 6/6

  • The locus match probability is the probability that this locus is a match no matter the amount of overall mismatches.

mismatch, i.e. 9/10, 7/8 or 5/6

  • The locus match probability is the probability that this locus is a match no matter the amount of overall mismatches.

So this probability provides information on the probability that this locus will be a match..


8.2 Locus match probabilities in Hap-E search: Not displayed

In some cases the value is not defined and no locus match probability is displayed:

Hap-E search

ATLAS search

match

  • When p1 = 0 (division by zero, not defined).

mismatch

  • When p2 = 0 (division by zero, not defined).
  • When a donor/CBU already has at least two known mismatches. As Hap-E only calculates match probabilities for up to 2 mismatches, Hap-E also is not able to calculate the locus-specific match probabilities in case of the third mismatch.

inexplicable donors

  • When a donor's phenotype cannot be explained by the haplotype frequency sets used for probabilistic matching. It is therefore impossible to calculate match probabilities both at the considered loci in total and per-locus. 

match

  • When p1 = 0 (division by zero, not defined).

mismatch

  • When p2 = 0 (division by zero, not defined).
  • When a donor/CBU already has at least two known mismatches. As Hap-E only calculates match probabilities for up to 2 mismatches, Hap-E also is not able to calculate the locus-specific match probabilities in case of the third mismatch.


inexplicable donors

  • When a donor's phenotype cannot be explained by the haplotype frequency sets used for probabilistic matching. It is therefore impossible to calculate match probabilities both at the considered loci in total and per-locus. 


8.3 Locus match probabilities in Hap-E search: Example 1

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