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At the moment, the Search & Match Service (with the Hap-E Search matching algorithm) is providing the full list of potential cord blood units, when a three and/or four mismatch search is performed. These lists are commonly very long and therefor therefore search coordinators currently find it difficult to select the most suitable potential stem cell source in Search & Match when they perform a three and/or four mismatch CBU search.
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Three and/or four mismatch cord blood search results do not have any locus specific match probabilities calculated, the results are currently sorted within their match class (e.g. 5/8, 4/8) only by TNC or CD34+. The Hap-E Search matching algorithm returns more potential cord blood units than the legacy Search & Match Service. Many of these “extra” cord blood units tend to be low probability options to be selected for a patient in need of a transplant, because these cord blood units have low HLA resolution typing or missing allele typing.
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