Versions Compared

Old Version 40

changes.mady.by.user Alicia Venter

Saved on

compared with

New Version 41

changes.mady.by.user Mark Melchers

Saved on

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.

...

Expand
titleWhat Haplotype Frequencies will be used for the probability matching?
WMDA has calculated and applied many specific haplotype frequency sets to the Search & Match Service. Read more on the following page. To find which haplotype frequency set got used for a donor or CBU, consult the full report. 
Expand
titleHow can I request a Search Advise for a Patient?

If you are experiencing difficulties in your selection of a donor/cord for your patient, you can request a search advice from the WMDA HLA experts. To request an advise, go to your patient list, click on the patient ID and at the bottom of the Update patient form you will find a button with 'Request Search Advisory'. An email message will then open with the patient information and some additional fields with requirements. Please fill out as much as possible and send the email. You will receive the advice also by email.

Expand
titleWhat is the difference between setting filters and heading filters within the search results report?

There is no functional difference. The filters you see on top of the headings in the search results are the frequently used filters. All filters are applied to all search results. Even the ones that are not on the page that is currently displayed. 

Expand
titleIt seems like the search results are automatically ordered on age for adults and TNC for cords. Is that correct?

The default sorting criteria from Hap-E Search and ATLAS for donors are: 

1. HLA

2. probability in 10% intervals

3. donor age ascending


The default sorting criteria from Hap-E Search and ATLAS for cords are: 

1. HLA (6/6, 5/6, 4/6 categories)

2. Number of total nucleated cells (TNC) for cords within HLA match category

...

Expand
titleWhy are there sometimes probabilities missing?

This can have several causes.

  • Overall match probabilities and locus-specific match probabilities are missing: this is most likely because the HLA typing of the donor/CBU is not consistent with any known haplotypes for the population that the donor is in (inexplicable donor). Without haplotypical context, the matching engine is not able to provide match probabilities. 
  • Only locus-specific match probabilities are missing: It does not make sense to display the probability of match for a specific locus in case of a mismatch
    • Because the known match probability is 100% and therefore there is no probability of a(n additional) mismatch and therefore displaying match probabilities in case of an additional mismatch does not make sense.
    • Because the probability of an additional mismatch is 0% for another reason, e.g. because the donor is low resolution typed at 3 loci and therefore in theory be a match, but it is very unlikely.  

See the following page for more information: Feature differences Hap-E Search vs Optimatch

Expand
titleWhy do i sometimes see donors or CBUs with no information other than HLA and Ethnicity?

Image Added

In some cases you may see donors or CBUs that look like the one above. There is not information regarding GRID, registry, CBB, age or any other non-HLA/ethnicity information. The reason for this is that the search was in the Hap-E search result, but can no longer be found in our internal database. We are therefore not able to show any additional information other then what the Hap-E matching engine provided.

This can have several causes.

  • The search was not recently performed and the patient is not in the ACT state. 
  • It is a donor from the Japanese registry (ION-4364). In that case there is registry information available, but all donors seem to be 33 years old and there are no identifiers. This is because Japan Marrow Donor Program does not send any information except for HLA to our systems. 

How to resolve: 

  • If the search is not recent, it is best to refresh the searches for a patient. See https://share.wmda.info/x/dZUZGQ for instructions on how to do that. 
  • If the donor is from the Japan Marrow Donor Program, contact this registry for more information. 
Expand
titleWhat are inexplicable donors/CBUs?

At the top of search results you can see how many donors or CBUs are inexplicable. 

Inexplicable donors or CBUs are records that have HLA that cannot be explained by a combination of two haplotypes in the haplotype frequency set (Haplotype frequency sets in the HAP-E matching algorithm of the Search & Match Service) for the population that the donor or CBU is part of. To find out which haplotype frequency set was used, you can use the full report

The number there corresponds to the set on the Haplotype frequency sets in the HAP-E matching algorithm of the Search & Match Service share page. 

Because the HLA typing that this donor/CBU has cannot be explained, Hap-E also cannot calculate match probabilities. Currently these donors appear on the bottom of the match class that they are part of (e.g. 10/10, 9/10, 7/8). We are working on a way to move potentially relevant but inexplicable donors to a better place in the search results. 

The number of inexplicable donors/CBUs mentioned therefore serves as a reminder that there are potentially relevant search results available that can be found at the bottom of the match class. 

...