Educational webinars
- 12 November 2020: slides | video
- 22 March 2021: slides | video
- 1 September 2022: slides | video
- 5 December 2023: slides | video
Feature | Optimatch | HAP-E | ATLAS | ||||||
---|---|---|---|---|---|---|---|---|---|
AB search | Yes (separate search) | Included in standard search (only n/n and n-1/n) | No. Technically possible, but turned off for performance reasons. | No. Not possible because donors without DRB1 are not accepted by ATLAS as valid donors. No | |||||
ABDR search | Yes | Yes | Yes | ||||||
AB Antigen, DRB1 allele match (for cord matching) | Yes | To Do | Yes | Not planned. Lack of community interest. requires fundamental code changes. No | |||||
Sorting performed by Matching Engine | Yes | No. WMDA Search and Match performs sorting. | Yes, but WMDA will override with own sort parameters | ||||||
Information about probability of match at other allele at already mismatched locus | No | Yes | Yes | ||||||
Flexible scaling to accommodate periods of high and low use of the engine | No | Yes | Yes | Easy updating of HF Sets | No | Yes | Yes | ||
g group level matching | Yes | YesNo → Yes | Yes (actually "P" group matching) | ||||||
G group level matching (leading to less populations and lesser performance for some of populations, but better matching for other populations). | No | No | Yes, but turned off at the moment in favour of g group matching. | ||||||
automatic refresh of patient searches | Yes | delta search handled by Search | Yes | Yes delta search handled by Search | |||||
differential results from matching algorithm. → algorithm tells what has changed. | NoNo | Yes | NoYes | ||||||
HLA validation of DRB3, DRB4, DRB5, DQA1 and other loci not considered for matching | No | Yes | Possible in Optimatch. Not implemented in WMDA setup for Search & Match v1. | Yes | Loci other than A, B, C, DRB1, DQB1 and DPB1 are not validated or imported by ATLAS and therefore also not returned. ? | ||||
Performing a mismatch search will return also (potentially) matched results | Yes | Yes | No (currently) for donors, Yes for cords | ||||||
Amount of searches that can reasonably run in parallel | 3 | 12 | 1 per vCore in the DB | ||||||
Consider | considercombination of serological and | dnaDNA typing for match probability | Yes | No | No | ||||
support for > 2 mismatches | No | Possible in Optimatch. Not implemented in WMDA setup for Search & Match v1. | Not yet. Will can also be 2 or more mismatches on ABDRB1. will be done. >=4/8 all loci to be considered need to be typed at high resolution for patient. | yes, but only for cords >= 4/8 | |||||
HLA imputation based on patient organisation and/or poolNo | Possible in Optimatch. Not implemented in WMDA setup for Search & Match v1. | Yes?. | Available at go-live. | ||||||
mismatches per locus can be sent directly to matching engine? | Yes, during actual search and during retrieval. | No. Server side filtering needed for API and GUI | Yes, but not fast. For performance reasons WMDA will perform server side filtering for GUI use. | ||||||
null allele handling | Does not return donors with XX or also with some MAC codes? Not matching homozygous typing. | Only considers null alleles with allele frequency higher than 0% in donor population or high resolution null allele. | Will will return donors which match haplotype with known null allele or high resolution null allele. Will be marked in search results. | ? | |||||
TCE handling for DPB1 | probabilityAllele frequency based | ?TCE3 | alleleAllele frequency based TCE3 | TCE3? based on probabilities? Did not provide allele frequencies | patient level imputation | global set? Everything is INT patient | pool + ethn determine which HF set | ?The determination of permissiveness follows the logic described in Crocchiolo et al., 2009. The TCE group assignment is based on functional distances as described in Crivello et al., 2016 | TCE3 |
match grade handling when multiple potential ARDs in donor typing | When only 1 ARD in ambiguity list occurs in the known haplotypes → allele match ("A") | Always "Potential" even if there is only 1 ARD in known haplotypes (100% potential match) | |||||||
broad serology level matching | yes | No. Split serology will only match same split serology or when donor/patient is broad serology. Not matched when patient/donor has split serology that is different but both share same broad serology. e.g.
| AB Antigen, DRB1 allele match not supported. | ||||||
Lowest probability in search results | 1 (0 is very rare circumstances). 0% match probability for haplotype frequency matching displayed as 1% if allele frequency based matching indicates possible match. | 0 | 0 | ||||||
matching probability when donor haplotype cannot be explained | No match probabilities displayed. | No match probabilities displayed. | No match probabilities displayed. | ||||||
directionality of DPB1 nonpermissive mismatch indicated? | Yes | Yes | Yes | ||||||
Indicate in search result that it is unclear whether allele or antigen mismatch | Yes | No | No | ||||||
donors returned with A, B and C and/or DQB1, but not DQB1 | Yes in AB search | yes but filtered out | donors without DRB1 are never returned | ||||||
HLA typing other than A, B, C, DRB1, DQB1 and DPB1 (e.g. DRB3/4/5 or DPA1) available in search results and full report | Yes | yes, only in full report due to design choice in Search & Match | no. | ||||||
Meaning of locus-specific match probability | Locus match probability no matter the amount of overall mismatches | Locus match probability in the case of additional mismatch | Locus match probability no matter the amount of overall mismatches | ||||||
Handling of "NEW" alleles (alleles that do not yet have an official allele name). See https://onlinelibrary.wiley.com/doi/10.1111/tan.15048 | ? | Supported for Donors and Patients. Search & Match including Dataupload currently only supports NEW alleles for Patients (so Search & Match). | Not currently supported. Support will be added in the future using ticket https://github.com/Anthony-Nolan/Atlas/issues/876 | ||||||
Homozygous mismatch: how many mismatches | Configurable. Currently set to "2" in WMDA Search & Match. | 2? |