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This page was last modified on 18 May 2016, at 10:57.

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Condition

Inherited retinal degeneration with progressive loss of photoreceptor cells

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Individual at risk

Donor

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Guidance at RECRUITMENT/CT/WORK-UP

ACCEPTABLE

Justification for guidance

There is no evidence to support an adverse effect of stem cell mobilisation in donors with RP. Indeed, G-CSF has been shown to increase photoreceptor survival and is even discussed as a novel therapeutic approach:

Oishi A, Otani A, Sasahara M, Kojima H, Nakamura H, Yodoi Y, Yoshimura N. Granulocyte colony-stimulating factor protects retinal photoreceptor cells against light-induced damage. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5629-35. doi: 10.1167/iovs.08-1711. Epub 2008 Aug 1.Β [1].


Any impact of bone marrow collection also seems highly unlikely.