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- Condition
- Individual at risk
- Guidance at RECRUITMENT
- Guidance at CT/WORK-UP
- Justification for guidance
- References
Condition
An abnormal reduction in bone mineral density Condition associated with snoring, where the sufferer has periods of 'apnoea' (not breathing). It is associated with an increased risk of fractures. The most common aetiology relates to post-menopausal reductions in circulating oestrogen, and as such this condition far more commonly affects females.stroke and heart disease. See more information at: https://en.wikipedia.org/wiki/Obstructive_sleep_apnea
Individual at risk
Donor
Guidance at RECRUITMENT
Establish cause, and if not otherwise excluded may join.Accept if no cardio-respiratory abnormalities
Guidance at CT/WORK-UP
Establish cause, and if not otherwise excluded may donate by PBSC only. Inform requesting transplant centre that donor is PBSC only.
Hormone replacement therapy for post-menopausal females is usually not derived from human tissues, and therefore acceptable in this context.
Justification for guidance
Shearing stresses applied to the pelvis and lower spine during bone marrow harvest may be a particular risk in donors with osteoporosis.
References
- Accept for PBSC donation, if no cardiorespiratory abnormalities
- Accept for BM donation, subject to anaesthetic assessment at work-up. Document any additional risk factors for cardiovascular disease. Anaesthetist for BM procedure must be made aware of condition and pre-anaesthetic assessment at work-up.
Justification for guidance
Will need anaesthetic assessment at medical if for bone marrow harvest.
References
Based on discussion in WMDA Donor Suitability Committee (December 2019)Gladden K, Spill GR. Iliac fracture after a bone marrow biopsy. Pm R 2011; 3(12): 1150-2.