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Clicking on the Patient ID link will open the update patient form to allow users to perform the following functions:

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Edit/Update patient details: Modify any details for the given patient, except the Patient ID.

Request Search Advisory - You can request search advice from the WMDA HLA experts if you are facing a difficult search case.

Deactivate patient – This will deactivate the patient record, remove the record from Optimatch and place them in the Inactive patient list.

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PLEASE NOTE: Update of any of the patients details such as HLA, will automatically trigger a new match run. This might change previous search results.

Only if you remove all ticks in the search type block, no new match run is triggered, but any previous search results will be lost as well.

This shows you if a search is still in progress or if there are results available for review.

If the search is still in progress, you see the following icon/text: Image Removed 

You will see "A,B,DR Donors: Match run in progress..." if you are only running a donor search and additionally "Cords: Match run in progress..." if you are also running a cord search. The page will automatically refresh if the results are available.

If you see the search results, you can click on these to go to the search results page.Image Removed

Key points to remember:

If you have triggered a search for the first time, then the system automatically performs a 10/10 donor match using the haplotype frequency algorithm. The system will downscale the match run to either 8/8 or 6/6, depending on the number of loci available of the patient.

For cords, the default match run is a 8/10 cord match at allele level using the haplotype frequency algorithm.

The number of donors/cords found is displayed for the type of match performed. 

If you have applied any filters (CMV or gender) to searches then the system will display the number of donors/cords against the type of match performed and filters applied. On screen filters are not saved to the search results in the patient list table.

When you hover over the filter icon, you can see which filter(s) was applied.

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Clicking on the Patient ID link will open the update patient form to allow you to perform the following functions:

Reactivate patient - This will reactivate the patient record and place them back in the active patient list. It is not possible to edit any details of the form; only the details of active patients can be edited. After clicking on the reactivate patient button, the system shows the the following message:

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Click on "reactivate patient" again and a new match run is automatically triggered and this will update the search results that were known from before. If you performed a donor and cord match run before, the system will update both searches.

When executing a donor search, thesystem performs a 10/10 match run using the haplotype algorithm by default. The match type selection after the initial donor match run consist of a drop-down menu called loci to consider:

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You can change the loci to consider to:Image Removed

If you would like to change to mismatched match types, you first have to click on the "Run a mismatch search" button. The system will then perform a new match run including mismatched donors. After retrieving these search results, the match type menu will consist of two selection drop-down menus: "Loci to consider" and "Mismatch type". You can choose between the following match types:Image Removed

The Loci to consider drop-down menu is changed a little bit and you can choose between the following options:

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For the Mismatch type drop-down menu you can choose between the following mismatch types, depending on your selection in the Loci to consider menu:

Loci to consider: n/10 search:Image Removed

Loci to consider: n/8 search (at HLA-A, B ,DRB1, DQB1) and n/8 search (at HLA-A, B, C, DRB1):Image Removed Image Removed

Loci to consider: n/6 search:

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When executing a cords search the default is to run a 8/10 match run at allele level (n/10 search + two mismatches on any locus) using the haplotype algorithm.

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The Loci to consider drop-down menu consists of the following options:

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For the Mismatch type drop-down menu you can choose between the following mismatch types, depending on your selection in the Loci to consider menu:

Loci to consider: n/10 search:Image Removed

Loci to consider: n/8 search (at HLA-A, B ,DRB1, DQB1) and n/8 search (at HLA-A, B, C, DRB1):Image Removed Image Removed

Loci to consider: n/6 search allele matched and n/6 search class I matched at antigen level, class II matched on allele level:

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After you have selected a new match type, click on the "Get search results" button to retrieve your new results.

NOTES:

• If you patient's HLA does not include information from 5 loci (A, B, C, DRB1, DQB1), the system will automatically downscale the default match run to either 8/8 or 6/6, depending on the number of loci available for the patient. This is also shown in your patient list in the results column when you retrieved the results.
• If you are requesting mismatch results, the table with the match results will first show you all potential 10/10 matched donors followed by the mismatch match type you requested.
• If the mismatch type drop-down shows you an option with >=, it will also show you lower match grades after the requested results.

Standard (default): search results are grouped by the number of matching values on allele level and within the groups sorted by probability. E.g. 10 loci considered (n=10) and 1 mismatch, headers are 10/10 and 9/10 (potential) allele matches; within group sorted by probability of associated number of mismatches. This standard grouping/sorting is available for all options: both matching algorithms (allele frequencies and haplotype frequencies) and all mismatch types (zero, one two mismatches)

Optional: search results can be grouped together and sorted by the sum of probabilities of potential matched and mismatched donors when selecting one or two mismatches. These options are useful in case of many potential matched (and single mismatched) donors with low probabilities. E.g. 10 loci considered (n=10) and 1 mismatch, header +9/10 (potential) allele matches; sorted by sum of probability of 10/10 and 9/10.

PLEASE NOTE: This grouping/sorting block is not visible when you select haplotype frequencies and zero mismatches or allele frequencies.

PLEASE NOTE: This grouping/sorting is available for both donor and CBU searches. However, for CBU searches only for 1 and 2 mismatches.

The method of grouping/sorting will also be shown in your summary of results:

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EXAMPLES

When haplotype frequencies are selected and 10 loci are considered (n=10) with 1 mismatch, and sorted by sum of probabilities - include 0 and 1 mismatches.

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When the "haplotype frequencies" matching algorithm is selected and 10 loci are considered (n=10) with 2 mismatches, and sorted by sum of probabilities - include 0, 1, and 2 mismatches.

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In the grey bar, you can find the HLA of your patient. This header will move with you when you are looking at results more below.=

Probability of a mismatch at 0 loci, 1 locus, and 2 loci. The percentages are only shown when you are using the haplotype frequency algorithm and are based on the match type you have been chosen (out of 6 then 6 loci are considered; out of 10 then 10 loci are considered).

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The five squares above the probability percentages are representing, respectively, locus A, B, C, DRB1, and DQB1. They are showing in letter/colour codes if a certain loci of a donor/cord is likely to match with your patient or not.

• A - Green: allele match or identical antigen recognition domain
• P - Blue: potential allele match
• L - Orange: allele mismatch, but antigen match; The HLA typing is shown in the same colour and underlined
• M - Red: antigen mismatch. The HLA typing is shown in the same colour and bold
• -   - not specified

NOTE: When you are using for cords the match type ≥4/6 (at HLA-A, B, DRB1), Class I matched at antigen level and Class II matched at allele level, the probabilities are calculated based on allele level match for all loci and not only for DRB1.

Various studies have shown a potential beneficial effect if the HLA‐DPB1 classification based on T‐Cell Epitopes (TCE) is considered in donor selection. Among the 9/10 and 10/10 donor candidates, those with a permissive DPB1 constellation are preferred over those showing a non‐permissive DPB1 constellation. The implementation in OptiMatch is called "DPB1 TCE3 grading" and is based on the following publications and uses the new score based algorithm that was realised with 3 TCE groups [3].

1. Zino E, Frumento G, Marktel S, et al.A T‐cell epitope encoded by a subset of HLA‐DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.Blood (2004) 103:1417‐24.
2. Zino E, Vago L, Di Terlizzi S, et al. Frequency and targeted detection of HLA‐DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.Biol Blood Marrow Transplant (2007) 13:1031‐40.
3. Crivello P, Zito L, Sizzano F, et al. The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA‐DPB1 Mismatches in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant (2015) 21:233‐41.

DPB1 TCE3 evaluation is performed and displayed for A, B, DR typed donors under the following conditions:

• Patient DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
• Donor DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
• The donor must be in the group of potential '9/10' and '10/10' allele matches. Therefore, it is implicitly assumed that a 10/10 search is configured and can be accessed. In case of 8/8 and 6/6 donor searches or cord blood searches, there will be no DPB1 TCE3 grading.

The results of the DPB1 TCE3 grading is shown below the donor’s DPB1 values by using the following symbols:

The explanation of the symbols is also provided when hovering the symbols.

Ambiguities in patient and/or donor HLA‐DPB1 may lead to multiple possible TCE classifications. The probability values for the respectively potentially permissive,non‐permissive in GvH direction or non‐permissive in HvG direction are provided upon hover over the symbol. The probability values of the A‐symbol are divided over more than 1 TCE group.
The probabilities are based on the consensus HLA‐DPB1 allele frequencies and are rounded to one percentage point. It should be noted that HLA‐DPB1 linkage disequilibrium with the other HLA‐loci is not considered.

This column shows you the ION code of the registry or cord blood bank where the donor or cord is registered followed by the abbreviated name.

When you hover over the abbreviated name, the full name becomes visible.

This column may also shows you an icon that indicates that the registry is either WMDA accredited or WMDA qualified. If no icon is present next to the ION code, then the registry is not WMDA qualified or accredited.

Image Modified: the icon that indicates that the registry has a "WMDA accredited" or "WMDA qualified" status

When you hover over the icon, the icon indicates whether the registry has been WMDA qualified or whether the registry has been fully accredited. Also the validity period of the qualification/accreditation is visible.

Image Modified: The icon with a "Q" and a silver/grey V: WMDA Qualified

Image Modified:The icon with an "A" and a gold/yellow V: WMDA Accredited

 : registry is accredited for the period 2004 to April 19, 2020

When viewing a CBU search report you can also determine from the icon whether or not the cord bank is accredited and what accreditation they have.

Image Modified: This icon indicated that a cord bank has been accredited for only FACT.

Image Modified: This icon indicated that a cord bank has been accredited for both FACT and AABB.

 When you hover over the icon, it displays the accreditation status the bank has.

If you expand the donor/ cord details, the probability of a match per locus becomes visible:

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This also correspondents with the letter/colour code from the five squares in the column probability of mismatches. These probabilities are only calculated for the 5 loci A, B, C, DRB1, and DQB1.

GRID, Global Registration Identifier for Donors, is a new ID for donors (not for CBUs) that is globally unique. The first 4 numbers of the GRID refer to the ION of the organisation where the donor is registered. From July 1st 2019, GRID will become the primary ID for communication purposes between organisations.

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Ethnic group: The system uses the same ethnic groups as defined for the EMDIS system:

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