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In the grey bar, you can find the HLA of your patient. This header will move with you when you are looking at results more below.

Probability of a mismatch at 0 loci, 1 locus, and 2 loci. The percentages are only shown when you are using the haplotype frequency algorithm and are based on the match type you have been chosen (out of 6 then 6 loci are considered; out of 10 then 10 loci are considered).

The five squares above the probability percentages are representing, respectively, locus A, B, C, DRB1, and DQB1. They are showing in letter/colour codes if a certain loci of a donor/cord is likely to match with your patient or not.

• A - Green: allele match or identical antigen recognition domain
• P - Blue: potential allele match
• L - Orange: allele mismatch, but antigen match; The HLA typing is shown in the same colour and underlined
• M - Red: antigen mismatch. The HLA typing is shown in the same colour and bold
• -   - not specified

NOTE: When you are using for cords the match type ≥4/6 (at HLA-A, B, DRB1), Class I matched at antigen level and Class II matched at allele level, the probabilities are calculated based on allele level match for all loci and not only for DRB1.

Various studies have shown a potential beneficial effect if the HLA‐DPB1 classification based on T‐Cell Epitopes (TCE) is considered in donor selection. Among the 9/10 and 10/10 donor candidates, those with a permissive DPB1 constellation are preferred over those showing a non‐permissive DPB1 constellation. The implementation in OptiMatch is called "DPB1 TCE3 grading" and is based on the following publications and uses the new score based algorithm that was realised with 3 TCE groups [3].

1. Zino E, Frumento G, Marktel S, et al.A T‐cell epitope encoded by a subset of HLA‐DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.Blood (2004) 103:1417‐24.
2. Zino E, Vago L, Di Terlizzi S, et al. Frequency and targeted detection of HLA‐DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.Biol Blood Marrow Transplant (2007) 13:1031‐40.
3. Crivello P, Zito L, Sizzano F, et al. The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA‐DPB1 Mismatches in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant (2015) 21:233‐41.

DPB1 TCE3 evaluation is performed and displayed for A, B, DR typed potential donors under the following conditions:

• Patient DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
• Donor DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
• The donor must be in the group of potential '9/10' and '10/10' allele matches. Therefore, it is implicitly assumed that a 10/10 search is configured and can be accessed. In case of 8/8 and 6/6 donor searches or cord blood searches, there will be no DPB1 TCE3 grading.

The results of the DPB1 TCE3 grading is shown below the donor’s DPB1 values by using the following symbols:

The explanation of the symbols is also provided when hovering the symbols.

Ambiguities in patient and/or donor HLA‐DPB1 may lead to multiple possible TCE classifications. The probability values for the respectively potentially permissive,non‐permissive in GvH direction or non‐permissive in HvG direction are provided upon hover over the symbol. The probability values of the A‐symbol are divided over more than 1 TCE group.
The probabilities are based on the consensus HLA‐DPB1 allele frequencies and are rounded to one percentage point. It should be noted that HLA‐DPB1 linkage disequilibrium with the other HLA‐loci is not considered.

CMV status and date determined (YYYY-MM-DD)

Possible values:
N = Both IgG and IgM negative
Q = Questionable / Unclear
G = IgG positive, IgM negative
M = IgG negative, IgM positive
B = Both IgG and IgM positive
P = IgG or IgM positive, test did not differentiate
H = IgG positive, IgM not tested
O = IgG negative, IgM not tested

As seen in the second entry, a value for the CMV status is not required to be entered. 

If you expand the donor/ cord details, the probability of a match per locus becomes visible:

This also correspondents with the letter/colour code from the five squares in the column probability of mismatches. These probabilities are only calculated for the 5 loci A, B, C, DRB1, and DQB1.

GRID, Global Registration Identifier for Donors, is a new ID for donors (not for CBUs) that is globally unique. The first 4 numbers of the GRID refer to the ION of the organisation where the donor is registered. From July 1st 2019, GRID will become the primary ID for communication purposes between organisations.

Ethnic group: The system uses the same ethnic groups as defined for the EMDIS system: