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captionFigure 8: Patient list; active and inactive

     

  



Within the patient list you can perform various other functions listed below:

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Actions

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Description

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Sorting using column headings

If you have a large number of patients, you can sort them using the following column headings:

Active patients (second row, left side).

Inactive patients (second row, right side).

Within the table of listed Active patients you can manage your patients by performing the following actions listed below:

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Once the match process is completed, the number of matched donors/cords and short summary of the search will be presented in the column "Results" in the patient list. This link redirects you to the search results details. When a user clicks on the search results they are presented with a search results page consisting of the following parts:

  • Patient details
  • Match results for (patient ID)
  • Registry code information

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  • ID
  • Summary of search settings used
  • Search results


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captionFigure 12: Search results



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Actions

Description

Change maximum number of records displayeddisplayeed

The system by default shows you 250 search results. You can expand this to 500 records or reduce it to 15, 50 or 100 records per page.

After you have selected another maximum number, click on the "Get search results" button to retrieve the extra records. All results can now be viewed and are not limited to the top 2500 results.

PLEASE NOTE: If you do increase the number of results displayed, the search and/or PLEASE NOTE: If you do increase the number of results displayed, the search and/or applying of filters will take longer to perform in this case.

Patient details

In the patient details box, all medical details of your patient that were filled out at the "Add patient" form are shown. (Figure 15). By default, this box is collapsed at the search results page.

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captionFigure 15: Search results: Patient details


Match results table

An overview of the match results table of donor search results

INSERT SC OF PATIENT DETAILS WHEN UPDATED 

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Match results table

An overview of the match results table of donor search results and cord search results are shown in figure 16 and 17. These results are from searches using the haplotype frequency algorithm. 

By default the donor match results are sorted by:

1. HLA match grade (e.g. first 8/8 then 7/8, 6/8)

2. Probability Match probability in 10% intervals (defaultdescending)

3. Donor age in 5 year intervals(ascending)


By default the cord match results are sorted by:

1. HLA (6/6, 5/6, 4/6match grade (e.g. first 8/8 then 7/8, 6/8)

2. Number of total nucleated cells (TNC) for cordsNOTE: By default, cord search results are sorted at matching categories depending on the selection you made in the "loci to consider" drop-down menu; The probabilities are also based on allele level matching only, so please be aware of this when using the n/6 (at HLA-A, B, DRB1), Class I matched at antigen level and Class II matched at allele level match type.(TNC, descending)


Overview of donor search match results

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captionFigure 16: Donor match results table

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Abbreviation / column

Description

HLA patient

In the grey bar, you can find the HLA of your patient. This sticky header will move with you when you are looking at results more below.

Probability of mismatches

0, 1, 2

Probability of a mismatch at 0 loci, 1 locus, and 2 loci. The percentages are based on the match type you have been chosen (out of 6 then 3 loci are considered; out of 10 then 5 loci are considered).

The five first five squares above the probability percentages are representing, respectively, locus A, B, C, DRB1, and DQB1. They are showing in letter/colour codes if a certain locus of a donor/cord is likely to match with your patient or not.

  • A - Green: allele match or identical antigen recognition domain
  • P - Blue: potential allele match
  • L - Orange: allele mismatch, but antigen match; The HLA typing is shown in the same colour and underlined
  • M - Red: antigen mismatch. The HLA typing is shown in the same colour and bold
  • -   - not specified
NOTE: When you are using for cords the match type ≥4/6 (at HLA-A, B, DRB1), Class I matched at antigen level and Class II matched at allele level, the probabilities are calculated based on allele level match for all loci and not only for DRB1.
DPB1 TCE3 grading model

DPB1 TCE3 evaluation is performed and displayed for A, B, DR typed potential donors under the following conditions:

  • Patient DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
  • Donor DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
  • The donor must be in the group of potential '9/10' and '10/10' allele matches. Therefore, it is implicitly assumed that a 10/10 search is configured and can be accessed. In case of 8/8 and 6/6 donor searches or cord blood searches, there will be no DPB1 TCE3 grading.

The results of the DPB1 TCE3 grading is shown below the donor’s DPB1 values by using the following symbols:using the following symbols above the DPB1 alleles of the donor:

  • A - Green: allele match or identical antigen recognition domain
  • P - Blue: permissive DPB1 mismatch
  • G - red: non-permissive DPB1 mismatch in the graft versus host direction.
  • H - red: non-permissive DPB1 mismatch in the host versus graft direction.
  • X - grey: ambiguous or undetermined DPB1 match grade 

The explanation of the symbols is also provided when hovering the symbols.


Ambiguities in patient and/or donor HLA‐DPB1 may lead to multiple possible TCE classifications. The probability values for the respectively potentially permissive,non‐permissive in GvH direction or non‐permissive in HvG direction are provided upon hover over the symbol. The probability values of the A‐symbol are divided over more than 1 TCE group. 


The probabilities are based on the consensus HLA‐DPB1 allele frequencies and are rounded to one percentage point. It should be noted that HLA‐DPB1 linkage disequilibrium with the other HLA‐loci is not considered.

Age

Age of donor/cord

Gender

Sex: M = male, F = female

Blood group

Blood group, e.g. A+ = blood group A, rhesus positive, B- = blood group B, rhesus negative

CMV

CMV status and date determined (YYYY-MM-DD)

Possible values:
N = Both IgG and IgM negative
Q = Questionable / Unclear
G = IgG positive, IgM negative
M = IgG negative, IgM positive
B = Both IgG and IgM positive
P = IgG or IgM positive, test did not differentiate
H = IgG positive, IgM not tested
O = IgG negative, IgM not tested

As seen in the second entry, a value for the CMV status is may not required to always be enteredavailable

Probability of match per locus

Within the donor/ cord details, the probability of a match per locus is displayed:

This also correspondents with the letter/colour code from the five squares in the column probability of mismatches. These probabilities are only calculated for the 5 loci A, B, C, DRB1, and DQB1.

GRID

GRID, Global Registration Identifier for Donors, is a new an ID for donors (not for CBUs) that is globally unique. The first 4 numbers of the GRID refer to the ION of the organisation where the donor is registered or was registered . Since July 1st 2019, GRID has become the primary ID for communication purposes between organisations.initially. 

Ethnicity

Ethnic group: The system uses the same ethnic groups as defined for the EMDIS system:

The ethnic groups are as follows; 

Schermafbeelding 2016-11-08 om 16.46.37.png

StatusStatus of a donor or CBU. For donors, the status can be available (AV), reserved for a patient (RS), temporarily unavailable (TU)

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