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System Overview

Currently no footer

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caption	Figure 5: Navigation levels

Navigational Toolbar

The Navigational Tool bar is displayed across the top of the screen. This toolbar is also referred to as ribbon in some instances. This toolbar displays links that take you to the specific section you wish to view/manage.

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Button	Description
Logo	No functionality.
Dashboard	Link to the main page of the service, displaying visual data, quick links for "Add Patient" and "Patient List", information on donor care and important dates alongside a calendar.
Add Patient	This opens a form that allows users to register the details for a new patient and initiate a donor search.
Patient List	This section lists all active and inactive patients. Within this section users are allowed to manage their own or organisational patients.
User name/profile	This section contains now only the logout functionality, the logout button becomes visible once the username/profile is clicked.
Logout	This action will sign you off and return you to the login page.

Home

Currently no home page

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Add patient, update patient, view patient

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The patient ID should be unique and the system will check for duplicates when you validate the data by clicking on the Add patient button. The patient ID cannot be changed when you update your patient (read only field).
HLA should be entered with a colon (:) as separator.
HLA strings cannot be entered into the HLA fields; you can use the DNA Type Lookup Tool at the top right corner to lookup the corresponding MAC code.
During matching the entered HLA values will be converted to one or more g/p groups and all further matching calculations will be done at that level.
Dates can be entered either by using the calendar or just by typing. When you enter the date manually, please ensure they conform to the ISO date format of YYYY-MM-DD which is also shown in light grey (mask) in the date fields. Date of birth can also be in the future.
Use the tab key to move from field to field. When using the tab key on the HLA fields, the cursor will move as such that you can first enter both locus values, before moving to the next locus.
After you are finished entering the patient's details, please click on the "Search" button at the bottom of the page. This will trigger a validation of the entered data.
If the system finds any issues they will be highlighted it will highlight the errors in RED at the top of the form stating the reasons for it not saving the data, and will also display warnings in AMBER.
If the system detects no problems, then the details entered are stored in the database and a match run is automatically triggered for the patient.
By default, the system will attempt to start to run a 10/10 matched search but it is dependent on the number of HLA loci completed for the patient. If you only want to register your patient, make sure that both check boxes for donor and cord search are set to no in the section search type. This prevents the triggering of a search.
If you did not enter HLA from your patient for all 5 loci; A, B, C, DRB1, DQB1, the system will not perform a 10/10 match run, but will downscale the match run to either 8/8 or 6/6 depending on the amount of HLA loci available from your patient.

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Abbreviation / column	Description
HLA patient	In the grey barbetween two grey bars, in a white space, you can find the HLA of your patient. This sticky header will move with you when you are looking at results more below.
Probability of mismatches 0, 1, 2	Probability of a mismatch at 0 loci, 1 locus, and 2 loci. The percentages are based on the match type you have been chosen (out of 6 then 3 loci are considered; out of 10 then 5 loci are considered). The first five squares above the probability percentages are representing, respectively, locus A, B, C, DRB1, and DQB1. They are showing in letter/colour codes if a certain locus of a donor/cord is likely to match with your patient or not. A - Green: allele match or identical antigen recognition domain P - Blue: potential allele match L - Orange: allele mismatch, but antigen match; The HLA typing is shown in the same colour and underlined M - Red: antigen mismatch. The HLA typing is shown in the same colour and bold - - not specified
DPB1 TCE3 grading model	DPB1 TCE3 evaluation is performed and displayed for ~~A, B, DR typed~~ potential donors under the following conditions: Patient DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed. Donor DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed. The donor must be in the group of potential '9/10' and '10/10' allele matches. Therefore, it is implicitly assumed that a 10/10 search is configured and can be accessed. In case of 8/8 and 6/6 donor searches or cord blood searches, there will be no DPB1 TCE3 grading. The results of the DPB1 TCE3 grading is shown below the donor’s DPB1 values by using the following symbols above the DPB1 alleles of the donor: A - Green: allele match or identical antigen recognition domain P - Blue: permissive DPB1 mismatch G - red: non-permissive DPB1 mismatch in the graft versus host direction. H - red: non-permissive DPB1 mismatch in the host versus graft direction. X - grey: ambiguous or undetermined DPB1 match grade The explanation of the symbols is also provided when hovering the symbols. Ambiguities in patient and/or donor HLA‐DPB1 may lead to multiple possible TCE classifications. The probability values for the respectively potentially permissive,non‐permissive in GvH direction or non‐permissive in HvG direction are provided upon hover over the symbol. The probabilities are based on the consensus HLA‐DPB1 allele frequencies and are rounded to one percentage point. It should be noted that HLA‐DPB1 linkage disequilibrium with the other HLA‐loci is not considered.
Age	Age of donor/cord
Gender	Sex: M = male, F = female
Blood group	Blood group, e.g. A+ = blood group A, rhesus positive, B- = blood group B, rhesus negative
CMV	CMV status Possible values: N = Both IgG and IgM negative Q = Questionable / Unclear G = IgG positive, IgM negative M = IgG negative, IgM positive B = Both IgG and IgM positive P = IgG or IgM positive, test did not differentiate H = IgG positive, IgM not tested O = IgG negative, IgM not tested As seen in the second entry, a value for the CMV status may not always be available.
Probability of match per locus	Within the donor/ cord details, the probability of a match per locus is displayed: This also correspondents with the letter/colour code from the five squares in the column probability of mismatches. These probabilities are only calculated for the 5 loci A, B, C, DRB1, and DQB1.
GRID	GRID, Global Registration Identifier for Donors, is an ID for donors (not for CBUs) that is globally unique. The first 4 numbers of the GRID refer to the ION of the organisation where the donor is registered or was registered initially.
Ethnicity	Ethnic group: The system uses the same ethnic groups as defined for the EMDIS system: The ethnic groups are as follows;
Status	Status of a donor or CBU. For donors, the status can be available (AV), reserved for a patient (RS), temporarily unavailable (TU)