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Abbreviation / column

Description

HLA patient

In between two grey bars, in a white space, you can find the HLA of your patient. This sticky header will move with you when you are looking at results more below.

Probability of mismatches

0, 1, 2

Probability of a mismatch at 0 loci, 1 locus, and 2 loci. The percentages are based on the match type you have been chosen (out of 6 then 3 loci are considered; out of 10 then 5 loci are considered).

The first five squares above the probability percentages are representing, respectively, locus A, B, C, DRB1, and DQB1. They are showing in letter/colour codes if a certain locus of a donor/cord is likely to match with your patient or not.

  • A - Green: allele match or identical antigen recognition domain
  • P - Blue: potential allele match
  • L - Orange: allele mismatch, but antigen match; The HLA typing is shown in the same colour and underlined
  • M - Red: antigen mismatch. The HLA typing is shown in the same colour and bold
  • -   - not specified
DPB1 TCE3 grading model

The sixth square indicates the DPB1 match grade. 

DPB1 TCE3 evaluation is performed and displayed for A, B, DR typed potential for potential donors under the following conditions:

  • Patient DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
  • Donor DPB1 values must be present. Ambiguities in the form of multiple alleles codes, G‐ codes, etc. are allowed.
  • The donor must be in the group of potential '9/10' and '10/10' allele matches. Therefore, it is implicitly assumed that a 10/10 search is configured and can be accessed. In case of 8/8 and 6/6 donor searches or cord blood searches, there will be no DPB1 TCE3 grading.

The results of the DPB1 TCE3 grading is shown below the donor’s DPB1 values by using the following symbols above the DPB1 alleles of the donor:

  • A - Green: allele match or identical antigen recognition domain
  • P - Blue: permissive DPB1 mismatch
  • G - red: non-permissive DPB1 mismatch in the graft versus host direction (GvH).
  • H - red: non-permissive DPB1 mismatch in the host versus graft direction (HvG).
  • X - grey: ambiguous or undetermined DPB1 match grade 

The explanation of the symbols is also provided when hovering the symbols.


Ambiguities in patient and/or donor HLA‐DPB1 may lead to multiple possible TCE classifications. The probability values for the respectively potentially permissive, non‐permissive in GvH direction or non‐permissive in HvG direction are provided upon hover over the symbol. 


The probabilities are based on the consensus HLA‐DPB1 allele frequencies and are rounded to one percentage point. It should be noted that HLA‐DPB1 linkage disequilibrium with the other HLA‐loci is not considered.

Age

Age of donor/cord

Gender

Sex: M = male, F = female

Blood group

Blood group, e.g. A+ = blood group A, rhesus positive, B- = blood group B, rhesus negative

CMV

CMV status

Possible values:
N = Both IgG and IgM negative
Q = Questionable / Unclear
G = IgG positive, IgM negative
M = IgG negative, IgM positive
B = Both IgG and IgM positive
P = IgG or IgM positive, test did not differentiate
H = IgG positive, IgM not tested
O = IgG negative, IgM not tested

As seen in the second entry, a value for the CMV status may not always be available. 

Probability of match per locus

Within the donor/ cord details, the probability of a match per locus is displayed:

This also correspondents with the letter/colour code from the five squares in the column probability of mismatches. These probabilities are only calculated for the 5 loci A, B, C, DRB1, and DQB1.

GRID

GRID, Global Registration Identifier for Donors, is an ID for donors (not for CBUs) that is globally unique. The first 4 numbers of the GRID refer to the ION of the organisation where the donor is registered or was registered initially. 

Ethnicity

Ethnic group: The system uses the same ethnic groups as defined for the EMDIS system:

The ethnic groups are as follows; 

Schermafbeelding 2016-11-08 om 16.46.37.png

StatusStatus of a donor or CBU. For donors, the status can be available (AV), reserved for a patient (RS), temporarily unavailable (TU)

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