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titleWhy do some search requests take long to retrieve?

Many factors can impact how long it takes to retrieve search results. The most likely reasons that your search is taking some time is that it is a difficult search or the HLA of your patient is very common and will retrieve many records. We initially only run a 10/10, 8/8 or 6/6 search to make sure we retrieve you results as quickly as possible. Mismatch searches can take longer since there are many more options to assess before providing the results.

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titleWhat are inexplicable donors?

Inexplicable donors or CBUs are records that have HLA that cannot be explained by a combination of two haplotypes in the haplotype frequency (HF) set for the population that the donor or CBU is part of. 

Because the HLA typing of this donor/CBU cannot be explained, the matching algorithm is unable to calculate match probabilities. Currently these donors appear on the bottom of the match class that they are part of (e.g. 10/10, 9/10, 7/8). The number of inexplicable donors/CBUs mentioned therefore serves as a reminder that there are potentially relevant search results available that can be found at the bottom of the match class.

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titleCan I cancel a search if it’s taking too long?
 It is not necessary to cancel a search. We recommend logging out of the application and returning at a later time to review your results.

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titleWhat are inexplicable donors/CBUs?

At the top of search results you can see how many donors or CBUs are inexplicable. 

Inexplicable donors or CBUs are records that have HLA that cannot be explained by a combination of two haplotypes in the haplotype frequency set (Haplotype frequency sets in the HAP-E matching algorithm of the Search & Match Service) for the population that the donor or CBU is part of. To find out which haplotype frequency set was used, you can use the full report

The number there corresponds to the set on the Haplotype frequency sets in the HAP-E matching algorithm of the Search & Match Service share page. 

Because the HLA typing that this donor/CBU has cannot be explained, Hap-E also cannot calculate match probabilities. Currently these donors appear on the bottom of the match class that they are part of (e.g. 10/10, 9/10, 7/8). We are working on a way to move potentially relevant but inexplicable donors to a better place in the search results. 

The number of inexplicable donors/CBUs mentioned therefore serves as a reminder that there are potentially relevant search results available that can be found at the bottom of the match class. 

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