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  • Allele matching is used to calculate overall and locus-specific match probabilities. 
  • Match class (e.g. 5/6, 4/6) is based on Antigen level matching at the A* and B* locus whereas regular matching at antigen recognition domain (ARD) level is used for DRB1.  

An antigen match is done according to method SI3 of this paper

World Marrow Donor Association framework for the implementation of HLA matching programs in hematopoietic stem cell donor registries and cord blood banks | Bone Marrow Transplantation (nature.com)

Examples of antigen matches and mismatches can be found in this table: 

Image Added


After confirming it works correctly we will make it available in the production environment (https://searchmatch.wmda.info/)

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