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Patient typing | Donor typing | Hap-E
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A*03:01, A*01:11N | A*03:01, A*03:01 | matches | matches |
A*03:01, A*01:11N | A*03:01, A*02:125N | matches | matches |
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If there is a haplotype compatible with the donor typing containing A*02:125N then |
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A*03:01, A*01:11N | A*03:01, A*02:GFJM | matches |
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A*03:01, A*03:01 | A*03:01, A*02:XX | matches |
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A*03:01, A*03:01 | A*03:01, A*01:01:01G | does not match |
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A*01:11N, A*02:125N | A*03:01, A*03:01 | does not match |
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8.1 Locus match probabilities: Definition
Hap-E search | ATLAS search |
|---|
match, i.e. 10/10, 8/8 or 6/6- The locus match probability is the relative probability that this locus is a match in the 1 mismatch case.
mismatch, i.e. 9/10, 7/8 or 5/6- The locus match probability is the relative probability that this locus is a match in the 2 mismatch case.
So this probability provides information on which locus the next mismatch will occur. | match, i.e. 10/10, 8/8 or 6/6- The locus match probability is the probability that this locus is a match no matter the amount of overall mismatches.
mismatch, i.e. 9/10, 7/8 or 5/6- The locus match probability is the probability that this locus is a match no matter the amount of overall mismatches.
So this probability provides information on the probability that this locus will be a match.. |
8.2 Locus match probabilities in Hap-E search: Not displayed
In some cases the value is not defined and no locus match probability is displayed:
Hap-E search | ATLAS search |
|---|
match- When p1 = 0 (division by zero, not defined).
mismatch- When p2 = 0 (division by zero, not defined).
- When a donor/CBU already has at least two known mismatches. As Hap-E only calculates match probabilities for up to 2 mismatches, Hap-E also is not able to calculate the locus-specific match probabilities in case of the third mismatch.
inexplicable donors - When a donor's phenotype cannot be explained by the haplotype frequency sets used for probabilistic matching. It is therefore impossible to calculate match probabilities both at the considered loci in total and per-locus.
| match- When p1 = 0 (division by zero, not defined).
mismatch- When p2 = 0 (division by zero, not defined).
- When a donor/CBU already has at least two known mismatches. As Hap-E only calculates match probabilities for up to 2 mismatches, Hap-E also is not able to calculate the locus-specific match probabilities in case of the third mismatch.
inexplicable donors
- When a donor's phenotype cannot be explained by the haplotype frequency sets used for probabilistic matching. It is therefore impossible to calculate match probabilities both at the considered loci in total and per-locus.
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8.3 Locus match probabilities in Hap-E search: Example 1
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