What to do when all results do not show any overall probability
If this is the case then most likely all results are also marked When none of the results display an overall probability, it's likely that all outcomes are labeled as "inexplicable." . You can see identify this by comparing the total number of results vs with the number count of inexplicable donors/cbusCBUs.
If this is the case then most likely the PATIENT has HLA that cannot be explained by a In such instances, it indicates that the patient's HLA makeup cannot be adequately explained by the combination of two haplotypes in the applied haplotype frequency (HF) set that was applied to the patient HLA by the matching engine. When no "pool" is provided this is . If no specific "Pool Country Code" is designated, the global HF set and if there is a pool provided then the country code provided is used to pick is utilized. However, if a pool is specified, the corresponding HF set for the given country code is employed.
How to "fix" the issue
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Resolving the Issue
To render the patient's HLA profile explicable, there are two
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potential solutions:
Option 1:
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Adjust the "Pool Country Code" of the patient to "No Value
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." This ensures the application of the global HF set
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, which is more likely to
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encompass a combination of haplotypes
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explaining the patient's typing. If
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this doesn't suffice, setting the "Pool Country Code" to the
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patient's country of genetic background may be beneficial in some cases.
Option 2:
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Retype the patient at high resolution
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to eliminate any ambiguity in the HLA typing
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.
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With all
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uncertainties removed from the patient's side, the matching engine
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can calculate matching probabilities
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.
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Upon implementation, the results may display:
- Low and intermediate resolution donors with an overall match probability of 0%.
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- This occurs because there isn't a combination of two haplotypes in the donor's HF set
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- matching the patient's genotype. Note that despite the 0% probability, some of these donors
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- might still be viable matches, particularly if they share the same genetic background as the patient.
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- In the ATLAS matching engine, such donors may not be returned.
- A high-
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- resolution typed donor
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- with a 100% match
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- , although this is improbable considering the patient's highly unique genotype,
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- it
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- remains a possibility.
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