You are viewing an old version of this page. View the current version.

Compare with Current View Page History

« Previous Version 7 Next »

The USA guidelines for cord blood selection recommend a minimum 4/6 (HLA-A, -B antigen, -DRB1 allele/ARD) match as asuitable option for some patients. Some of the WMDA member organisations have implemented to run a routine HLA-A, -B antigen, -DRB1 allele/ARD cord search with up to two mismatches as a default. Therefore, WMDA is implementing this option as well in Search & Match Service.

A, B Antigen, DRB1 ARD level CBU searches are now available in the sandbox environment (https://sandbox-search.wmda.info/). 

It was built to function in the same way as was implemented in legacy Search & Match. This means that: 

  • Allele matching is used to calculate overall and locus-specific match probabilities. 
  • Match class (e.g. 5/6, 4/6) is based on Antigen level matching at the A* and B* locus whereas regular matching at antigen recognition domain (ARD) level is used for DRB1.  

After confirming it works correctly we will make it available in the production environment (https://searchmatch.wmda.info/)

Please help us in testing this feature. Please contact us at support@wmda.info if you have any questions. 

Known behaviour. 

As mentioned, CBUs are assigned the right match class (6/6 vs 5/6 vs 4/6) in A, B Antigen, DRB1 ARD level CBU searches. We are aware of a small issue. In some cases we may not indicate that a locus has a mismatch where there is one. This is only the case in A, B Antigen, DRB1 ARD level CBU searches and not in regular searches. We are working on a fix for this. 

  • No labels