Locus-specific match probabilities for ATLAS searches
Locus-specific match probabilities for p0, p1 and p2 are available in the full donor and CBU reports of ATLAS search results.
These results can be accessed by navigating to the full report by selecting the "full report" button that is displayed for every search result.
Why are locus-specific match probabilities not available for Hap-E searches?
Because of the different definitions between match probabilities calculated by ATLAS and Hap-E and the nature of how match probabilities are displayed by Hap-E, it is not possible to display locus-specific match probabilities for p0, p1 and p2.
How to interpret locus-specific match probabilities in the full report
For Hap-E search results
Based on the type of search, the locus-specific match probability displays the relative probability that this locus is a match in the next mismatch case. Therefore, it is not possible to distinguish between p0, p1 and p2 locus-specific match probabilities.
For additional information about the definition of the match probabilities in Hap-E, please visit this page.
For ATLAS search results
The locus-specific match probabilities are defined for p0, p1 and p2 in the full donor and CBU reports of ATLAS search results:
- The match probability for p0 is defined as the match probability for a specific locus in case of 0 mismatches
- The match probability for p1 is defined as the mismatch probability for a specific locus in case of 1 mismatches
- The match probability for p2 is defined as the mismatch probability for a specific locus in case of 2 mismatches
In the example below the matching probabilities for HLA-B and -DRB1 in case of 0 mismatches are 100%. For HLA-A and HLA-C, the matching probabilities are 98% and 1%, respectively.
In case of 1 mismatch, the mismatch probabilities for HLA-B and -DRB1 are 0%. For HLA-A and HLA-C, the mismatch probabilities are 2% and 97%, respectively.
1. Example locus-specific match probabilities ATLAS search