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Disclaimer
These guidelines exist as an aid to organisations in assessing the medical suitability of their (maternal) donors. Please be reminded that these guidelines are not intended to supersede local laws or requirements of national legislative bodies.
Guidance provided by the World Marrow Donor Association (WMDA) aims to provide minimum standards by which potential donors should be assessed.
The guidance below reflects the consensus opinion provided by the WMDA donor medical suitability committee. The purpose of this guidance is to provide globally harmonised medical assessment criteria which simultaneously protect the interest of donors whilst ensuring the safety of cellular products across international boundaries.
Two key concepts govern the assessment of donor health, namely restrictive criteria for donor risk and more permissive criteria for recipient risk
Procedure for creating and reviewing the donor medical suitability guidelines
To create and support this resource, the WMDA has established the donor medical suitability committee. Members of the committee represent all major regions in the world, and are themselves overseen by numerous competent authorities within their country of practice. Committee members are actively involved in donor centre and/or registry operations with experience in matters concerning unrelated donor medical suitability.
Submitting a request for review
WMDA welcomes requests for review of individual medical conditions from all those with responsibility for HSC donors, related or unrelated. This may be a medical condition not covered by the current guidance, or a request for clarification or review of current guidance.
Requests for new guidance, and feedback on existing guidance, are submitted to the donor medical suitability committee. Comments and justifications for the committee decision are documented, including justification for the decision. Regardless of the outcome, a formal response to the query is provided to the author of each submission in order to inform the registry/donor centre of the outcome of the discussion. Recommendations that are approved are posted to this website. Any controversies pertaining to the recommendations are added to the discussion section on the relevant page. You can click on the button on the right top corner of the page.
Related donors
Whilst this WMDA guidance is not specifically intended for related donors, those involved with the medical assessment of related donors should consider these recommendations.
Table 1 - Recommended minimum medical and lifestyle information obtained at recruitment
Table 2 - Recommended minimum medical and lifestyle information obtained at confirmatory/verification typing stage
Table 3 - Recommended minimum medical assessment at work-up
Table 4 - Recommended minimum standard of donor infectious disease marker testing
Table 5 - Recommended schedule of repeating donor assessments in the event of a delay to collection
Acupuncture, see Tattoo, body piercing and acupuncture
Alcoholism, see Alcohol intake
Alopecia areata, see Single organ autoimmune disease
Anaphylaxis, see Allergy
Angina, see Coronary artery disease
Ankylosing spondylitis, see Back complaints
Antiphospholipid syndrome, see Thrombosis and Thrombophilia
Antithrombin III (ATIII) deficiency, see Thrombosis and Thrombophilia
Aortic regurgitation, see Valvular heart disease
Aortic stenosis, see Valvular heart disease
Arterial thrombosis, see Thrombosis and Thrombophilia
Atrial fibrillation/flutter, see Arrhythmia
Atopy, see Allergy
Back, fracture, see Back complaints
Back, surgery, see Back complaints
Basal cell carcinoma, see Malignancy
Benign atrial/ventricular ectopics, see Arrhythmia
Bicuspid aortic valve, see Valvular heart disease
Blood pressure, see Hypertension
BMI, see Weight
Body piercing, see Tattoo, body piercing and acupuncture
Bronchial asthma, see Asthma
Brugada syndrome, see Arrhythmia
Budd-Chiari syndrome, see Thrombosis and Thrombophilia
Cancer, see Malignancy
Cerebral venous sinus thrombosis, see Thrombosis and Thrombophilia
Cevical carcinoma in-situ, see Malignancy
Choreoretinitis, see Inflammatory eye disease
Chronic fatigue syndrome, see Myalgic encephalomyelitis
Chronic obstructive pulmonary disease
CMV, see Cytomegalovirus
Coeliac/celiac disease, see Single organ autoimmune disease
Complete heart block, see Arrhythmia
COAD/COPD, see Chronic obstructive pulmonary disease
Conjunctivitis, see Inflammatory eye disease
Cornea transplant, see Prion-associated disease
Coumarin therapy, see Bleeding disorders
Creutzfeld-Jacob disease (CJD, vCJD), see Prion-associated disease
Crohn's disease, see Severe or systemic autoimmune disease
Deep vein thrombosis (DVT), see Thrombosis and Thrombophilia
Ebola, see Viral haemorrhagic fever
Ebstein anomaly, see Valvular heart disease
EBV, see Epstein Barr Virus
Emphysema, see Chronic obstructive pulmonary disease
Endoscopy, see Surgery
Episcleritis, see Inflammatory eye disease
Factor II (prothrombin) mutation, see Thrombosis and Thrombophilia
Factor V Leiden, see Thrombosis and Thrombophilia
First degree heart block, see Arrhythmia
Glomerulonephritis, see Renal disease
Goodpasture syndrome, see Severe or systemic autoimmune disease
Graves disease, see Single organ autoimmune disease
Guillain-Barre syndrome, see Severe or systemic autoimmune disease
Haemophilia (any type), see Bleeding disorders
Hashimoto thyroiditis, see Single organ autoimmune disease
Hayfever, see Allergy
HbC, HbD, HbE, HbO, see Haemoglobin disorder
Heart attack, see Coronary artery disease
Heart block, see Arrhythmia
Heart murmur, see Valvular heart disease
Heparin therapy, see Bleeding disorders
Hereditary haemorrhagic telangiectasia, see Bleeding disorders
Herniated intervertebral disc, see Back complaints
High affinity haemoglobin, see Haemoglobin disorder
High blood pressure, see Hypertension
Hormone replacement therapy, see Prion-associated disease
HSV, see Herpes Simplex Virus
Hyperthyroidism, see Single organ autoimmune disease
Hypothyroidism, see Single organ autoimmune disease
IgA nephropathy, see Renal disease
Immune thrombocytopenia, see Bleeding disorders
Implantable cardiac defibrillator (ICD), see Arrhythmia
Inflammatory bowel disease, see Severe or systemic autoimmune disease
Innocent murmur, see Valvular heart disease
Injection of non-prescription drugs
Iridocyclitis, see Inflammatory eye disease
Iritis, see Inflammatory eye disease
Ischaemic heart disease (IHD), see Coronary artery disease
Jugular vein thrombosis, see Thrombosis and Thrombophilia
Kidney stones, see Renal disease
Latex allergy, see Allergy
Left bundle branch block, see Arrhythmia
Long-QT syndrome, see Arrhythmia
Lown-Ganong-Levine syndrome, see Arrhythmia
Manic depressive disorder, see Bipolar affective disorder
Marburg, see Viral haemorrhagic fever
Mitral regurgitation, see Valvular heart disease
Mitral stenosis, see Valvular heart disease
Mitral valve prolapse, see Valvular heart disease
Monoclonal gammopathy of undetermined significance
Multiple sclerosis, see Severe or systemic autoimmune disease
Murmur, see Valvular heart disease
Myalgic encephalomyelitis (ME)
Myocardial infarction (MI), see Coronary artery disease
Needlestick injury, see Innoculation injury
Nephrectomy, see Renal disease
Nephritis, see Renal disease
Nephrolithiasis, see Renal disease
Nephrotic syndrome, see Renal disease
Osler-Weber-Rendu syndrome, see Bleeding disorders
Oral anticoagulant therapy, see Bleeding disorders
Overweight, see Weight
Pacemaker, see Arrhythmia
Paget-Schroetter syndrome, see Thrombosis and Thrombophilia
Pernicious anaemia, see Single organ autoimmune disease
Paroxysmal nocturnal haemoglobinuria (PNH), see Thrombosis and Thrombophilia
Portal vein thrombosis, see Thrombosis and Thrombophilia
Prolapsed intervertebral disc, see Back complaints
Protein C deficiency, see Thrombosis and Thrombophilia
Protein S deficiency, see Thrombosis and Thrombophilia
Prostitution, see High risk sexual behaviour
Psoriasis, see Single organ autoimmune disease
Pulmonary embolus/embolism (PE), see Thrombosis and Thrombophilia
Pulmonary regurgitation, see Valvular heart disease
Pulmonary stenosis, see Valvular heart disease
Renal colic, see Renal disease
Renal vein thrombosis, see Thrombosis and Thrombophilia
Rheumatoid arthritis, see Severe or systemic autoimmune disease
Right bundle branch block, see Arrhythmia
Sarcoidosis, see Severe or systemic autoimmune disease
Sciatica, see Back complaints
Scleritis, see Inflammatory eye disease
Scleroderma, see Severe or systemic autoimmune disease
Second degree heart block, see Arrhythmia
Seizure, see Epilepsy
Sex worker, see High risk sexual behaviour
Severe or systemic autoimmune disease
Sickle cell disease, see Haemoglobin disorder
Sickle cell trait, see Haemoglobin disorder
Single organ autoimmune disease
Sinus bradycardia, see Arrhythmia
Sinus tachycardia, see Arrhythmia
Spinal stenosis, see Back complaints
Spondylitis, see Back complaints
Spondylolisthesis, see Back complaints
Stroke, see Cerebrovascular disease
Supraventricular tachycardia, see Arrhythmia
SVT, see Arrhythmia
Systemic lupus erythematosus (SLE), see Severe or systemic autoimmune disease
Tattoo, body piercing and acupuncture
Thalassaemia, see Haemoglobin disorder
Thrombotic thrombocytopenic purpura (TTP), see Severe or systemic autoimmune disease or Bleeding disorders
Thyroid disease, see Single organ autoimmune disease
Transient ischaemic attack (TIA), see Cerebrovascular disease
Ulcerative colitis, see Severe or systemic autoimmune disease
Underweight, see Weight
Ventricular tachycardia/fibrillation, see Arrhythmia
Vitiligo, see Single organ autoimmune disease
Von Willebrand disease (vWD), see Bleeding disorders
Vitamin K deficiency, see Bleeding disorders
Warfarin therapy, see Bleeding disorders
Wegener granulomatosis, see Severe or systemic autoimmune disease
Wenckebach (Mobitz I) heart block, see Arrhythmia
Whiplash, see Back complaints