This page was last modified on 24 October 2016, at 19:46.
Space Index
Total number of pages: 102
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AAlcohol intakeContents This page was last modified on 15 Sept 2023, at 10:01. Individual at risk Donor / Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable if current or recent history of alcohol use disord
Allergy
Contents This page was last modified on 1 November 2016, at 13:33. Condition Any abnormal immune-mediated reaction to a drug or other external stimulus, such as rash, tongue-swelling, and difficulty breathing. Individual at Risk Donor / Recipient Gu
Anaemia
Contents This page was last modified on 18 May 2016, at 10:42. Individual at risk Donor / Recipient Recommendation at RECRUITMENT Establish cause and degree of anaemia. May be acceptable if benign cause and haemoglobin level is acceptable. Registries
Arrhythmia
Contents This page was last modified on 18 May 2016, at 10:06. Condition An abnormality of cardiac electrical activity, most commonly diagnosed by electrocardiography. Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood dona
Asthma
Contents This page was last modified on 18 May 2016, at 10:44. Condition A disease characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person. During an attack, the lining of the passage
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BBabesiosisContents This page was last modified on 18 May 2016, at 10:45. Condition Babesiosis Individual at risk Donor / Recipient Guidance at RECRUITMENT DEFER if ever diagnosed with or treated for disease Guidance at CT/WORK-UP Consider accepting donor if a
Back complaints
Contents This page was last modified on 1 November 2016, at 13:23. Introduction Back complaints are common and need to be considered on a case-by-case basis at both recruitment and CT/work-up stages. General guidance for adult volunteer donor (NA for
Benign tumours
Contents This page was last modified on 02/08/2018 Condition A benign tumor is a mass of cells (tumor) that lacks the ability to invade neighboring tissue or metastasize. These do not spread into, or invade, nearby tissues; however, they can sometimes be
Bipolar affective disorder
Contents This page was last modified on 18 May 2016, at 10:08. Condition Bipolar affective disorder. Also known as manic depression. Individual at Risk Donor / recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood dona
Bleeding disorders
Contents This page was last modified on 18 May 2016, at 10:30. Bleeding disorders not transmissible via HCST Clotting factors synthesized by liver or endothelia; nutritional / by medication; vascular disorders: Including: Haemophilia A and B including sym
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CCerebrovascular diseaseContents This page was last modified on 18 May 2016, at 10:46. Condition Disease of the vasculature of the brain. This includes: Stroke, or cerebrovascular accident, whether haemorrhagic or embolic Transient ischaemic attack Intracerebral haemorrhage, i
Chagas disease
Contents This page was last modified on 18 May 2016, at 10:10. Condition Chagas’ disease (Trypanosoma cruzi) Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) A past history of Ch
Chronic obstructive pulmonary disease
Contents This page was last modified on 18 May 2016, at 10:48. Condition COPD is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxiou
Coronary artery disease
Contents This page was last modified on 1 November 2016, at 13:20. Condition Atherosclerotic or thrombotic occlusion of the coronary vasculature. Pseudonyms and other related conditions include: Angina Ischaemic heart disease (IHD) Myocardial infarction
Coronavirus - SARS-CoV-2 & COVID-19
BACKGROUND A novel coronavirus (later named SARS-CoV-2, with the resulting illness named COVID-19) emerged in late 2019, with WHO declaring a global health emergency on 30 January 2020. The epidemic has since spread to all populated continents, with a glo
COVID-19 infection and risk exposure
COVID-19 infection and risk exposure History of COVID-19 infection Contact with COVID-19 – donors who report contact with a confirmed case Donor preparation Donation collection Planned cryopreservation Post-donation cryo-quarantine Summary table History o
Current sexual partner of infected individual
Contents This page was last modified on 18 May 2016, at 10:19. Condition Current sexual partner of person with hepatitis B infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation
Cytomegalovirus
Contents This page was last modified on 7 March 2015, at 23:43. Condition Herpesvirus causing self-limiting infection in immunocompetent individuals, but with potentially severe consequences in immuno-suppressed transplant patients. Individual at risk
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DDengue FeverContents This page was last modified on 18 May 2016, at 10:51. Condition Dengue fever Individual at risk Recipient Guidance at RECRUITMENT Accept any donor with a known history of dengue infection or travel to a dengue risk area. Guidance at CT Defe
Depression
Contents This page was last modified on 18 May 2016, at 10:14. Condition Depression, whether endogenous or exogenous in origin. Individual at Risk Donor / recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donat
Diabetes mellitus
Contents This page was last modified on 19 August 2013, at 17:51. Individual at risk Donor Guidance at RECRUITMENT UNACCEPTABLE Guidance at CT/WORK-UP ACCEPTABLE if type II diabetes controlled with diet or oral medication alone, and no other risk factors
Donor has been in a malaria risk area - for any amount of time - within the last 3 years
Contents This page was last modified on 20 August 2013, at 12:55. Individual at risk Recipient Guidance at RECRUITMENT ACCEPTABLE if donor has documented evidence of a negative validated malarial antibody test since return from malaria risk area. Othe
Donor has lived in a malaria risk area for 6 or more continuous months at any time of life
Contents This page was last modified on 20 August 2013, at 12:51. Individual at risk Recipient Guidance at RECRUITMENT ACCEPTABLE if donor has documented evidence of a negative validated malarial antibody test since return from malaria risk area. Othe
Donor has past history of malaria
Contents This page was last modified on 20 August 2013, at 12:58. Individual at risk Recipient Guidance at RECRUITMENT ACCEPTABLE if donor has documented evidence of a negative validated malarial antibody test since full recovery and cessation of trea
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EEczemaContents This page was last modified on 18 May 2016, at 10:15. Condition The term eczema may describe a range of persistent skin conditions, including dryness and recurring skin rashes that are characterized by one or more of these symptoms: redness, skin
Endometriosis
Contents This page was last modified on DD/MM/YYYY,. Condition Endometriosis is a condition that is caused by endometrium growing outside the uterus. Mostly in ovaries, the Fallopian tubes and tissue surrounding the uterus. Most common and directly relate
Epilepsy
Contents This page was last modified on 18 May 2016, at 10:53. Condition Epilepsy is a chronic neurological disorder characterized by recurrent brief episodes of involuntary shaking (seizures) which may involve a part of the body (partial) or the entire b
Epstein Barr Virus
Contents This page was last modified on 18 May 2016, at 10:52. Condition Herpes virus causing glandular fever (infectious mononucleosis). Individual at risk Recipient (and ?donor) Guidance at RECRUITMENT ACCEPTABLE Guidance at CT ACCEPTBALE Guidan
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FFibromyalgiaContents This page was last modified on 18 May 2016, at 10:16. Condition Fibromyalgia is a disorder of unknown etiology characterized by widespread pain, abnormal pain processing, sleep disturbance, fatigue and often psychological distress. People with fi
FORM: Suggestion for medical guideline
Recommendation for medical guideline Name of person completing the form: $name E-mail address: $email Proposed recommendation: $suggestion Other details : id: [entry.id] Created : [entry.createdBy] Owned :[entry.ownedBy] Date : [entry.created]
Former sexual partner of infected individual
Contents This page was last modified on 18 May 2016, at 10:21. Condition Former sexual partner of person with hepatitis B infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation)
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GGlaucomaContents This page was last modified on 8 March 2015, at 00:36. Condition Basic information Chronic optic nerve damage, characteristically associated with unstable or a sustained increase in the intraocular pressure Types (Primary) open-angled glaucoma
Gout
Contents This page was last modified on 4 December 2013, at 23:21. Condition Gout Individual at risk Donor Guidance at RECRUITMENT ACCEPTABLE Guidance at CT/WORK-UP ACCEPTABLE for bone marrow donation only Justification for guidance There have b
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HHaemoglobin disorderContents This page was last modified on 7 November 2014, at 23:37. Condition Inherited haemoglobin disorders are endemic through Africa, South-East Asia and the Caribbean and the Mediterranean, where the high allelic frequency offers some protection again
Hemochromatosis
Contents This page was last modified on 23-07-2018 Condition Hereditary haemochromatosis is an autosomal recessive disorder most frequently associated with mutations of the HFE gene. The estimated incidence of the C282Y mutation is 10% in people of northe
Hepatitis B
Hepatitis B
Hepatitis B infection - current
Contents This page was last modified on 18 May 2016, at 10:18. Individual at risk Recipient Condition Current hepatitis B infection Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable Guidance at CT/WO
Hepatitis B infection - past
Contents This page was last modified on 18 May 2016, at 10:18. Condition History of previous hepatitis B infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Acceptable if
Hepatitis C
Hepatitis C
Hepatitis C - Current sexual partner of infected individual
Contents This page was last modified on 18 May 2016, at 10:22. Condition Current sexual partner of person with hepatitis C infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donati
Hepatitis C - Former sexual partner of infected individual
Contents This page was last modified on 18 May 2016, at 10:22. Condition Former sexual partner of person with hepatitis C infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation)
Hepatitis C - Person sharing home with infected individual
Contents This page was last modified on 18 May 2016, at 10:23. Condition Household contact of person with hepatitis C infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Acc
Hepatitis C infection - current
Contents This page was last modified on 18 May 2016, at 10:22. Condition Current hepatitis C infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable Guidance at CT/
Hepatitis C infection - previous
Contents This page was last modified on 18 May 2016, at 10:22. Condition History of previous hepatitis C infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable. In
Hepatitis E
Acute infection (= HEV-RNA detectable, not IgG-positivity) At recruitment (only if donor reports, no test required): ACCEPTABLE if free of symptoms At CT (only if donor reports, no test required) DEFER for 4 months. If entirely free of symptoms, re-evalua
Herpes Simplex Virus
Contents This page was last modified on 8 March 2015, at 00:18. Condition HSV-1 and -2 are DNA viruses from Herpesviridae family, causing life-long chronic latent infection. Virus may reactivate from time to time. Both are transmitted by contact with an i
High risk sexual behaviour
Contents This page was last modified on 18 May 2016, at 10:54. Condition High-risk sexual behaviour is that which puts the donor at risk of infectious diseases which may then be transmitted to the recipient/patient. This risk occurs because the donor them
History of back surgery
Contents This page was last modified on 12 March 2013, at 13:37. Condition History of surgery Individual at risk Donor Guidance at RECRUITMENT ACCEPT FOR PBSC ONLY Guidance at CT/WORK-UP ACCEPT FOR PBSC ONLY Justification for guidance Pain or un
History of current or past herniated intevertebral disc
Contents This page was last modified on 1 November 2016, at 13:37. Condition History of back surgery Individual at risk Donor Guidance at RECRUITMENT for adult volunteer donor (NA for maternal donor (cord blood donation)) ACCEPT FOR PBSC ONLY Guidan
History of fracture, dislocation or instability
Contents This page was last modified on 19 August 2013, at 16:37. Condition History of fracture, dislocation or instability Individual at risk Donor Guidance at RECRUITMENT ACCEPT FOR PBSC ONLY Guidance at CT/WORK-UP ACCEPT FOR PBSC ONLY Justifica
HIV
@self
HIV infection
Contents This page was last modified on 18 May 2016, at 10:23. Condition HIV infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable Guidance at CT/WORK-UP Permanen
HIV infection – CURRENT SEXUAL PARTNER OF CONFIRMED CASE
Contents This page was last modified on 18 May 2016, at 10:24. Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Unacceptable Guidance at CT/WORK-UP Generally unacceptable. However,
HIV infection – FORMER SEXUAL PARTNER OF CONFIRMED CASE
Contents This page was last modified on 18 May 2016, at 10:24. Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Acceptable if more than 12 months from last sexual contact with infect
HTLV infection
Contents This page was last modified on 18 May 2016, at 10:17. Condition HTLV-I and HTLV-II are closely related RNA retroviruses that are transmitted parenterally and sexually, and typically cause life-long chronic infection. Individual at risk Recipient
Hypertension
Contents This page was last modified on 15 sept 2023, at 12:26. Condition High blood pressure. Individual at risk Donor Guidance at RECRUITMENT ACCEPTABLE Guidance at CT/WORK-UP ACCEPTABLE if well controlled. However, the presence of other cardiovascular
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IInflammatory eye diseaseContents This page was last modified on 8 March 2015, at 00:31. Condition Uveitis (iritis, iridocyclitis, chorioretinitis); scleritis; (episcleritis); (conjunctivitis) Basic information Inflammation affecting parts of one or both eyes Causes: Infectious
Injection of non-prescription drugs
Contents This page was last modified on 18 May 2016, at 10:26. Condition Injection of any drug or other substance not prescribed by a qualified physician or other healthcare professional. This encompasses, for example, drugs of addiction such as heroin, a
Innoculation injury
Contents This page was last modified on 18 May 2016, at 10:26. Condition Accidental penetration of the skin, or splash in the eye, with an object potentially contaminated with human bodily fluids. Individual at risk Recipient Guidance at RECRUITMENT
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MMalariaContents This page was last modified on 27 January 2022, at 11:55. Basic information A parasite infection of red blood cells, transmitted to humans by a particular type of mosquito (Anopheles) that is prevalent in rural tropical and sub-tropical settings.
Malignancy
Contents This page was last modified on 18 May 2016, at 10:07. Condition Includes all haematological and non-haematological malignancies, but excludes benign tumours. Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and mater
Mild, occasional episodes related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication
Contents This page was last modified on 1 November 2016, at 13:36. Condition Mild, occasional episodes of back pain related to exertion (incl sciatica). Minimal impact on activities of daily living and occasional use of medication Individual at risk Don
Monoclonal gammopathy of undetermined significance
Contents This page was last modified on 22/08/2018,. Condition Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for undetermined), formerly benign monoclonal gammopathy, is a condition in which an abnormal
Myalgic encephalomyelitis
Contents This page was last modified on 18 May 2016, at 10:11. Condition Myalgic encephalomyelitis (ME)/chronic fatigue syndrome A significantly debilitating medical disorder or group of disorders generally defined by persistent fatigue accompanied by o
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OObstructive Sleep ApnoeaContents Condition #Osteoporosis-Condition Individual at risk #Osteoporosis-Individualatrisk Guidance at RECRUITMENT #Osteoporosis-GuidanceatRECRUITMENT Guidance at CT/WORK-UP #Osteoporosis-GuidanceatCT/WORK-UP Justification for guidance #Osteoporosis-Jus
Osteoporosis
Contents This page was last modified on 20 August 2013, at 13:12. Condition An abnormal reduction in bone mineral density associated with an increased risk of fractures. The most common aetiology relates to post-menopausal reductions in circulating oestro
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PPages of section 'Alphabetical index of individual medical guidelines'Pages of section 'Alphabetical index of individual medical guidelines'
Person sharing home with infected individual
Contents This page was last modified on 18 May 2016, at 10:21. Condition Household contact of person with hepatitis B infection Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) A
Pneumothorax
Contents This page was last modified on 12 March 2013, at 13:51. Condition Pneumothorax is a collection of air or gas in the chest or pleural space that causes part or all of a lung to collapse. A primary (simple) pneumothorax occurs spontaneously, often
Pregnancy and breastfeeding
Contents This page was last modified on 27 July 2023, at 11:05. Pregnancy Individual at risk Donor Guidance at RECRUITMENT for adult volunteer donor (NA for maternal donor (cord blood donation)) ACCEPTABLE. It is very unlikely that a donor who is pregnant
Prion-associated disease
Contents This page was last modified on 18 May 2016, at 10:35. Condition Sporadic, familial and variant Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker diseases and fatal familial insomnia. Individual at risk Recipient Guidance at RECR
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RRenal diseaseContents This page was last modified on 18 May 2016, at 10:33. Renal diseases not transmissible via HCST Includes: Congenital malformation Nephrectomy after injury or dysfunctional kidney (e.g. hydronephrosis from childhood) Organ donation Nephrolithiasis
Retinitis pigmentosa
Contents This page was last modified on 18 May 2016, at 10:57. Condition Inherited retinal degeneration with progressive loss of photoreceptor cells Individual at risk Donor Guidance at RECRUITMENT/CT/WORK-UP ACCEPTABLE Justification for guidance Th
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SScoliosisContents This page was last modified on 19 August 2013, at 16:37. Condition Scoliosis Individual at risk Donor Guidance at RECRUITMENT ACCEPT IF NO SURGERY AND NO IMPACT ON ACTIVITIES OF DAILY LIVING Guidance at CT/WORK-UP ACCEPT IF NO SURGERY AND
Severe chronic back pain. Impacts on activities of daily living.
Contents This page was last modified on 19 August 2013, at 16:36. Condition Severe-chronic back pain. Impacts on activities of daily living. Individual at risk Donor Guidance at RECRUITMENT UNACCEPTABLE Guidance at CT/WORK-UP CASE-BY-CASE Just
Severe or systemic autoimmune disease
Contents This page was last modified on 18 May 2016, at 10:13. Condition Severe or Systemic autoimmune disease, including: Inflammatory bowel disease Multiple sclerosis (MS) Systemic lupus erythematosus (SLE) Inflammatory arthritis (including rheumatoid
Single organ autoimmune disease
Contents This page was last modified on 20 August 2013, at 15:03. Condition Single organ autoimmune disease, including: Condition Single organ autoimmune disease, including: Coeliac disease (celiac disease, sprue) Pernicious anaemia Alopecia areata Vitili
Surgery
Contents This page was last modified on 18 May 2016, at 17:25. Minor surgery Condition Any surgical procedure that does not involve general anesthesia or respiratory assistance e. g. nevus excision, dental surgery, skin biopsies, minor injuries / cuts
Syphilis
Contents This page was last modified on 28 Sept 2023, at 14:02. Condition Syphilis Individual at risk Donor / Recipient Guidance at RECRUITMENT for adult volunteer donor Accept Guidance at Recruitment and Testing of maternal donor (cord blood donation) if
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TTattoo, body piercing and acupunctureContents This page was last modified on 18 May 2016, at 10:01. Condition Any acupuncture, body piercing, permanent or semi-permanent make-up or tattoo. Individual at risk Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (
Thrombosis and Thrombophilia
Contents This page was last modified on 1 November 2016, at 13:29. Condition Thrombosis and thrombophilia Name of conditions (History of) Thrombosis, examples of conditions: Deep Venous Thrombosis (DVT) Pulmonary Embolism (PE) Portal Vein Thrombosis Ren
Toxoplasmosis
Contents This page was last modified on 7 March 2015, at 23:58. Condition Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii Individual at risk Recipient Guidance at RECRUITMENT ACCEPTABLE Guidance at CT ACCEPTABLE Gu
Transfusion
Contents This page was last modified on 20 August 2013, at 16:09. Condition Transfusion with blood components, products and derivatives. Individual at risk Recipient Guidance at RECRUITMENT ACCEPTABLE, unless: 1. received transfusion in country endemic fo
Tuberculosis
Contents This page was last modified on 31 May 2013, at 17:06. Condition Tuberculosis (Mycobacterium tuberculosis complex) Individual at risk Recipient Guidance at RECRUITMENT Defer enrolment until two (2) years after completed successful treatment.
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VVaccinationCOVID-19 VACCINATION HPC donors should be considered high priorities for vaccination against COVID-19, and encouraged to vaccinate as early as possible. In principle the vaccination should take precedence over the donation schedule, with donor mobilisatio
Valvular heart disease
Contents This page was last modified on 20 August 2013, at 16:18. Condition Valvular heart disease encompasses a wide range of structural and/or functional heart valve defects. This includes, amongst others: Aortic stenosis Aortic regurgitation Mitral s
Viral haemorrhagic fever
Contents This page was last modified on 18 May 2016, at 10:15. Condition Viral haemorrhagic fever, including Ebola and Marburg virus. Separate guidance exists for Dengue Fever https://share.wmda.info/x/oQBtEQ. Individual at risk Recipient Guidance at RECR
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WWeightContents This page was last modified on 1 November 2016, at 13:34. Individual at risk Donor Guidance at RECRUITMENT for adult volunteer donor (NA for maternal donor (cord blood donation)) ACCEPT if body mass index (BMI) is no greater than 40 kg/m2 and
West Nile Virus
Contents This page was last modified on 18 May 2016, at 10:41. Condition West Nile Virus (WNV) Individual at risk Donor / Recipient Guidance at RECRUITMENT for adult volunteer donor and maternal donor (cord blood donation) Accept if fully recovered De
WMDA Donor Medical Suitability Recommendations Main page
Disclaimer These guidelines exist as an aid to organisations in assessing the medical suitability of their potential donors. Please be reminded that these guidelines are not intended to supersede local laws or requirements of national legislative bodies.
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WMDA Donor Medical Suitability Recommendations
Ā
Disclaimer
These guidelines exist as an aid to unrelated adult haematopoietic stem cell donor registries in assessing the medical suitability of their donors. However, donor registries are reminded that these guidelines are not intended to supersede local laws or requirements of national legislative bodies.Ā
About the WMDA donor medical suitability guidelines
Guidance provided by the World Marrow Donor Association (WMDA) aims to provide minimum standards by which potential donors should be assessed.
The guidance below reflects the consensus opinion provided by the donor medical suitability working group of the WMDA. The purpose of this guidance is to provide globally harmonised medical assessment criteria which simultaneously protect the interest of donors whilst ensuring the safety of cellular products across international boundaries.
How donor medical suitability is assessed
Two key concepts govern the assessment of donor health, namely restrictive criteria for donor risk and more permissive criteria for recipient risk
Donor risk
Donation of hematopoietic stem cells (HSC) is an act of altruism, and may be to a recipient in a different country, with quite different moral, cultural and religious values.
Whilst it is recognised that the process of donation carries a small but unavoidable risk of harm to the donor, it is both the moral and legal responsibility of donor registries and donor centres to minimise any avoidable risk. This includes medical conditions that may increase the risk of harm to the donor before, during, and after the collection of HSC.
For this reason, medical criteria governing conditions that may increase donor risk are necessarily stringent, and certainly more so than would be the case if the individual were undergoing a procedure for therapeutic benefit.
In many cases it is difficult to establish a rigorous evidence base as justification for the criteria. In such cases, expert opinion of the underlying physiology of disease will be sought, and combined with knowledge of the known physiological changes associated with donation, as well as experience gained through several decades of HSC donor follow-up and adverse event reporting.
In general, if there is any doubt about the safety of the donor in the presence of a particular medical condition, it will be recommended that any donor with that condition be prevented from donating.
Recipient risk
By contrast, our recommendations regarding conditions that may put the recipient at risk are more lenient.
For many patients, an unrelated donor HSC transplant represents the only possibility of disease cure or long-term remission. Because of the diverse nature of HLA tissue-types, many patients will have a limited number of potentially matched donors. In such cases, donor medical conditions that may present a risk to the recipient alone should be reported to the transplant centre, who are best placed to make an informed risk-benefit judgement on whether to proceed with that particular donor.
There are obvious exceptions to this, however, in particular the carriage of transmissible agents which may have more deleterious effects in the recipient. These include infectious agents such as HIV, viral hepatitis and HTLV, prion-related diseases such as Creutzfeld-Jacob Disease, and carriage of autoreactive lymphocytes causing multi-system or severe single-organ autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis or inflammatory bowel disease.
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Procedure for creating and reviewing the donor medical suitability guidelines
To create and support this resource, the WMDA has established the donor medical suitability working group committee. Members of the committee represent all major regions in the world, and are themselves overseen by numerous competent authorities within their country of practice. Committee members are actively involved in donor centre and/or registry operations with experience in matters concerning unrelated donor medical suitability.
To create these initial guidelines, individual members of the working group were allocated criteria to write, which were then disseminated for review to the entire group. Consensus criteria were then agreed following consideration of all comments made.
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Submitting a request for review
The WMDA welcomes requests for review of individual medical conditions from all those with responsibility for HSC donors, related or unrelated. This may be a medical condition not covered by the current guidance, or a request for clarification or review of current guidance.
Requests for new guidance, and feedback on existing guidance, are submitted to the committee chair/designate and reviewed by committee members. Comments and justifications for the committee decision are documented, including justification for the decision. Regardless of the outcome, a formal response to the query is provided to the author of each submission in order to inform the registry/donor centre of the outcome of the discussion. Recommendations that are approved are posted to this website. Any controversies pertaining to the recommendations are added to the discussion section on the relevant page.
Please email Hung Yang hyang@abmdr.org.au with your request or comments. Please include your name and affiliation as we will be unable to review anonymous requests.
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Related donors
Whilst this WMDA guidance is not specifically intended for related donors, those involved with the medical assessment of related donors should consider these recommendations.
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WMDA Recommendations for assessing donor medical suitability
Table 1Ā - Recommended minimum medical and lifestyle information obtained at recruitment
Table 2Ā - Recommended minimum medical and lifestyle information obtained at confirmatory/verification typing stage
Table 3Ā - Recommended minimum medical assessment at work-up
Table 4Ā - Recommended minimum standard of donor infectious disease marker testing
Table 5Ā - Recommended schedule of repeating donor assessments in the event of a delay to collection
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Ā
Alphabetical index of individual medical guidelines
A
Acupuncture, seeĀ Tattoo, body piercing and acupuncture
Alcoholism, seeĀ Alcohol intake
Alopecia areata, seeĀ Single organ autoimmune disease
Anaphylaxis, seeĀ Allergy
Angina, seeĀ Coronary artery disease
Ankylosing spondylitis, seeĀ Back complaints
Antiphospholipid syndrome, seeĀ Thrombosis and Thrombophilia
Antithrombin III (ATIII) deficiency, seeĀ Thrombosis and Thrombophilia
Aortic regurgitation, seeĀ Valvular heart disease
Aortic stenosis, seeĀ Valvular heart disease
Arterial thrombosis, seeĀ Thrombosis and Thrombophilia
Atrial fibrillation/flutter, seeĀ Arrhythmia
Atopy, seeĀ Allergy
B
Back, fracture, seeĀ Back complaints
Back, surgery, seeĀ Back complaints
Basal cell carcinoma, seeĀ Malignancy
Benign atrial/ventricular ectopics, seeĀ Arrhythmia
Bicuspid aortic valve, seeĀ Valvular heart disease
Blood pressure, seeĀ Hypertension
BMI, seeĀ Weight
Body piercing, seeĀ Tattoo, body piercing and acupuncture
Bronchial asthma, seeĀ Asthma
Brugada syndrome, seeĀ Arrhythmia
Budd-Chiari syndrome, seeĀ Thrombosis and Thrombophilia
C
Cancer, seeĀ Malignancy
Cerebral venous sinus thrombosis, seeĀ Thrombosis and Thrombophilia
Cevical carcinoma in-situ, seeĀ Malignancy
Choreoretinitis, seeĀ Inflammatory eye disease
Chronic fatigue syndrome, seeĀ Myalgic encephalomyelitis
Chronic obstructive pulmonary disease
CMV, seeĀ Cytomegalovirus
Coeliac/celiac disease, seeĀ Single organ autoimmune disease
Complete heart block, seeĀ Arrhythmia
COAD/COPD, seeĀ Chronic obstructive pulmonary disease
Conjunctivitis, seeĀ Inflammatory eye disease
Cornea transplant, seeĀ Prion-associated disease
Coumarin therapy, seeĀ Bleeding disorders
Creutzfeld-Jacob disease (CJD, vCJD), seeĀ Prion-associated disease
Crohn's disease, seeĀ Severe or systemic autoimmune disease
D
Deep vein thrombosis (DVT), seeĀ Thrombosis and Thrombophilia
E
Ebola, seeĀ Viral haemorrhagic fever
Ebstein anomaly, seeĀ Valvular heart disease
EBV, seeĀ Epstein Barr Virus
Emphysema, seeĀ Chronic obstructive pulmonary disease
Endoscopy, seeĀ Surgery
Episcleritis, seeĀ Inflammatory eye disease
F
Factor II (prothrombin) mutation, seeĀ Thrombosis and Thrombophilia
Factor V Leiden, seeĀ Thrombosis and Thrombophilia
First degree heart block, seeĀ Arrhythmia
G
Glomerulonephritis, seeĀ Renal disease
Goodpasture syndrome, seeĀ Severe or systemic autoimmune disease
Graves disease, seeĀ Single organ autoimmune disease
Guillain-Barre syndrome, seeĀ Severe or systemic autoimmune disease
H
Haemophilia (any type), seeĀ Bleeding disorders
Hashimoto thyroiditis, seeĀ Single organ autoimmune disease
Hayfever, seeĀ Allergy
HbC, HbD, HbE, HbO, seeĀ Haemoglobin disorder
Heart attack, seeĀ Coronary artery disease
Heart block, seeĀ Arrhythmia
Heart murmur, seeĀ Valvular heart disease
Heparin therapy, seeĀ Bleeding disorders
Hereditary haemorrhagic telangiectasia, seeĀ Bleeding disorders
Herniated intervertebral disc, seeĀ Back complaints
High affinity haemoglobin, seeĀ Haemoglobin disorder
High blood pressure, seeĀ Hypertension
Hormone replacement therapy, seeĀ Prion-associated disease
HSV, seeĀ Herpes Simplex Virus
Hyperthyroidism, seeĀ Single organ autoimmune disease
Hypothyroidism, seeĀ Single organ autoimmune disease
I
IgA nephropathy, seeĀ Renal disease
Immune thrombocytopenia, seeĀ Bleeding disorders
Implantable cardiac defibrillator (ICD), seeĀ Arrhythmia
Inflammatory bowel disease, seeĀ Severe or systemic autoimmune disease
Innocent murmur, seeĀ Valvular heart disease
Injection of non-prescription drugs
Iridocyclitis, seeĀ Inflammatory eye disease
Iritis, seeĀ Inflammatory eye disease
Ischaemic heart disease (IHD), seeĀ Coronary artery disease
J
Jugular vein thrombosis, seeĀ Thrombosis and Thrombophilia
K
Kidney stones, seeĀ Renal disease
L
Latex allergy, seeĀ Allergy
Left bundle branch block, seeĀ Arrhythmia
Long-QT syndrome, seeĀ Arrhythmia
Lown-Ganong-Levine syndrome, seeĀ Arrhythmia
M
Manic depressive disorder, seeĀ Bipolar affective disorder
Marburg, seeĀ Viral haemorrhagic fever
Mitral regurgitation, seeĀ Valvular heart disease
Mitral stenosis, seeĀ Valvular heart disease
Mitral valve prolapse, seeĀ Valvular heart disease
Multiple sclerosis, seeĀ Severe or systemic autoimmune disease
Murmur, seeĀ Valvular heart disease
Myalgic encephalomyelitisĀ (ME)
Myocardial infarction (MI), seeĀ Coronary artery disease
N
Needlestick injury, seeĀ Innoculation injury
Nephrectomy, seeĀ Renal disease
Nephritis, seeĀ Renal disease
Nephrolithiasis, seeĀ Renal disease
Nephrotic syndrome, seeĀ Renal disease
O
Osler-Weber-Rendu syndrome, seeĀ Bleeding disorders
Oral anticoagulant therapy, seeĀ Bleeding disorders
Overweight, seeĀ Weight
P
Pacemaker, seeĀ Arrhythmia
Paget-Schroetter syndrome, seeĀ Thrombosis and Thrombophilia
Pernicious anaemia, seeĀ Single organ autoimmune disease
Paroxysmal nocturnal haemoglobinuria (PNH), seeĀ Thrombosis and Thrombophilia
Portal vein thrombosis, seeĀ Thrombosis and Thrombophilia
Prolapsed intervertebral disc, seeĀ Back complaints
Protein C deficiency, seeĀ Thrombosis and Thrombophilia
Protein S deficiency, seeĀ Thrombosis and Thrombophilia
Prostitution, seeĀ High risk sexual behaviour
Psoriasis, seeĀ Single organ autoimmune disease
Pulmonary embolus/embolism (PE), seeĀ Thrombosis and Thrombophilia
Pulmonary regurgitation, seeĀ Valvular heart disease
Pulmonary stenosis, seeĀ Valvular heart disease
Q
R
Renal colic, seeĀ Renal disease
Renal vein thrombosis, seeĀ Thrombosis and Thrombophilia
Rheumatoid arthritis, seeĀ Severe or systemic autoimmune disease
Right bundle branch block, seeĀ Arrhythmia
S
Sarcoidosis, seeĀ Severe or systemic autoimmune disease
Sciatica, seeĀ Back complaints
Scleritis, seeĀ Inflammatory eye disease
Scleroderma, seeĀ Severe or systemic autoimmune disease
Second degree heart block, seeĀ Arrhythmia
Seizure, seeĀ Epilepsy
Sex worker, seeĀ High risk sexual behaviour
Severe or systemic autoimmune disease
Sickle cell disease, seeĀ Haemoglobin disorder
Sickle cell trait, seeĀ Haemoglobin disorder
Single organ autoimmune disease
Sinus bradycardia, seeĀ Arrhythmia
Sinus tachycardia, seeĀ Arrhythmia
Spinal stenosis, seeĀ Back complaints
Spondylitis, seeĀ Back complaints
Spondylolisthesis, seeĀ Back complaints
Stroke, seeĀ Cerebrovascular disease
Supraventricular tachycardia, seeĀ Arrhythmia
SVT, seeĀ Arrhythmia
Systemic lupus erythematosus (SLE), seeĀ Severe or systemic autoimmune disease
T
Tattoo, body piercing and acupuncture
Thalassaemia, seeĀ Haemoglobin disorder
Thrombotic thrombocytopenic purpura (TTP), seeĀ Severe or systemic autoimmune diseaseĀ orĀ Bleeding disorders
Thyroid disease, seeĀ Single organ autoimmune disease
Transient ischaemic attack (TIA), seeĀ Cerebrovascular disease
U
Ulcerative colitis, seeĀ Severe or systemic autoimmune disease
Underweight, seeĀ Weight
V
Ventricular tachycardia/fibrillation, seeĀ Arrhythmia
Vitiligo, seeĀ Single organ autoimmune disease
Von Willebrand disease (vWD), seeĀ Bleeding disorders
Vitamin K deficiency, seeĀ Bleeding disorders
W
Warfarin therapy, seeĀ Bleeding disorders
Wegener granulomatosis, seeĀ Severe or systemic autoimmune disease
Wenckebach (Mobitz I) heart block, seeĀ Arrhythmia
Whiplash, seeĀ Back complaints